Use of Charged Aerosol Detection as an Orthogonal Quantification Technique for Drug Metabolites in Safety Testing (MIST)

Quantification of Drug Metabolites in Early-Stage Drug Discovery Testing Christopher Crafts, Bruce Bailey, John Waraska, Ian Acworth Thermo Fisher Scientific, Chelmsford, MA, USA Overview Methods Purpose: The use of a high efficiency UHPLC column and charged aerosol detection were evaluated…

Application note | 004316 Pharma Early-stage drug metabolite quantitation without radiolabels Authors Application benefits Katherine Lovejoy and Sylvia Grosse; • Method allows quantitation of metabolites without radiolabeling. • Method is ideal for quantitation of metabolites early in the drug development…

Improving the Quantitation of Unknown Impurity Analysis Using Dual-Gradient HPLC with Charged Aerosol Detection Christopher Crafts, Bruce Bailey, Marc Plante, John Waraska, and Ian Acworth ESA—A Dionex Company, Chelmsford, MA USA ABSTRACT INTRODUCTION Quantification of substances such as drug impurities…

Bruce Bailey, Ph. D. Thermo Fisher Scientific, Chelmsford, MA, USA Ap plica t ion Note 1 1 26 Metoprolol and Select Impurities Analysis Using a Hydrophilic Interaction Chromatography Method with Combined UV and Charged Aerosol Detection Key Words Vanquish UHPLC…