EAS: Improving the Quantitation of Unknown Impurity Analysis Using Dual-Gradient HPLC with Charged Aerosol Detection

Improving the Quantitation of Unknown Trace Impurity Analysis of Active Pharmaceutical Ingredients Using HPLC with Charged Aerosol Detection Kannan Srinvasan1, Marc Plante2, Chris Crafts2, Ian Acworth2, Paul Gamache2, and John Waraska2 Dionex Corporation, Sunnyvale, CA, USA; 2ESA––A ESA—A Dionex Company,…

APPLICATION NOTE 72594 Quantification of paclitaxel, its degradants, and related substances using UHPLC with charged aerosol detection Authors Michael Menz and Frank Steiner Thermo Fisher Scientific, Germering, Germany Ian Acworth Thermo Fisher Scientific, Chelmsford, MA, USA Keywords Vanquish Flex Duo…

Quantification of Drug Metabolites in Early-Stage Drug Discovery Testing Christopher Crafts, Bruce Bailey, John Waraska, Ian Acworth Thermo Fisher Scientific, Chelmsford, MA, USA Overview Methods Purpose: The use of a high efficiency UHPLC column and charged aerosol detection were evaluated…

Discover what you’re missing Thermo Scientific Charged Aerosol Detectors Hidden peaks revealed The analyte detection challenge No single liquid chromatography (LC) detector delivers ideal results. Often, one analyte responds more strongly than another, or may not respond at all. What…