Modern Size-Exclusion Chromatography Separations of Biosimilar Antibodies at Physiological pH and Ionic Strength

Application Note Expanding Size-Exclusion Chromatography Platform Method Versatility for Monoclonal Antibody Analysis Using Waters XBridge Premier Protein SEC Columns Stephan M. Koza, Hua Yang, Ying Qing Yu Waters Corporation Abstract Due to their potentially deleterious impact on immunogenic response or…

Application Note MaxPeak Premier Protein SEC 250 Å Column Lifetimes at Physiological pH for Polysorbate (Tween) Formulated Biosimilar Monoclonal Antibodies Stephan M. Koza, Hua Yang, Ying Qing Yu Waters Corporation Abstract Self-associated or aggregated protein impurities in therapeutics is a…

Application Note Evaluation of SEC-MALS Data Quality with Premier Protein SEC Columns Hua Yang, Stephan M. Koza, Ying Qing Yu Waters Corporation Abstract Size Exclusion Chromatography (SEC) coupled with multiangle light scattering (MALS) and UV/RI detection has been increasingly used…

Application Note Rapid Size Variant Analysis of Monoclonal Antibodies Using UPLC™ and HPLC Compatible MaxPeak™ Premier Protein SEC Columns Stephan M. Koza, Ying Qing Yu Waters Corporation Abstract High-throughput and rapid size-exclusion chromatography (SEC) methods can be useful to support…