Infrared Activation Enables Native Top-Down MS Analysis of Membrane Proteins and Protein Complexes

Activated-Ion Electron Transfer Dissociation Enables Electron-Based Dissociation Following Proton Transfer Charge Reduction Josh Hinkle1; Christopher Mullen1; Jean M Lodge2; Romain Huguet1; Michael S Westphall2; Joshua J Coon2; John E.P. Syka1 1Thermo Fisher Scientific, 355 River Oaks Pkwy, San Jose, CA,…

Optimized Fragmentation of Oligonucleotides Suppresses Undesired Fragmentation Products and Enables Confident Sequence Assignment Joshua D Hinkle,1 William McGee,2 Joshua P Salem,3 Chris Mullen,1 Scott R. Kronwitter,2 , Ping Yip,1 John E. P. Syka,1 James L. Stephenson Jr.,2 1Thermo Fisher Scientific,…

Mass spectrometry Rise to the molecular challenges of today and tomorrow Orbitrap Tribrid Apex mass spectrometer Rise to the molecular challenges of tomorrow With four new Tribrid editions, purpose-built for small molecule, multiomics, structural biology, and biopharma applications Introducing the…

Product specifications | 004346 Mass spectrometry Rise to the molecular challenges of today and tomorrow Orbitrap Tribrid Apex BioPharma mass spectrometer Benefits • Preserves native protein aggregates with enhanced ion decluttering via IR-laser desolvation • Single-platform versatility for intact biologics,…