An Integrated Workflow for Automated Calculation of Antibody‑Drug Conjugate (ADC) Drug‑to-Antibody Ratio (DAR)

Drug-to-Antibody Ratio (DAR) Calculation of Antibody-Drug Conjugates (ADCs) Using Automated Sample Preparation and Novel DAR Calculator Software Application Note Authors Introduction Jing Chen and Steve Murphy Antibody-drug conjugates (ADCs) are a new class of biotherapeutics that represent a rapidly growing…

Biopharma Workflow Solutions ACCELERATE ADC DAR CHARACTERIZATION WORKFLOW SOLUTIONS FOR ADC DAR ANALYSIS OVERVIEW The goal of drug discovery is to find drugs that have a wide differential between the effective dose and the dose where serious side effects are…

Application Note Pharma and Biopharma A streamlined drug-to-antibody ratio determination workflow for intact and deglycosylated antibody-drug conjugates Using the Agilent AssayMAP Bravo and Agilent 6545XT AdvanceBio accurate-mass quadrupole time-of-flight LC/MS system Authors Jerry Han, Zach Van Den Heuvel, and Steve…

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…