Released Glycan Analysis of Erythropoietin Using the ACQUITY Premier Glycan BEH C 18 AX Column and BioAccord System with ACQUITY Premier

LC-MS Analysis of Highly Sialylated Glycans Using MS Compatible Mixed Mode Chromatographic Separation Robert Birdsall and Ying Qing Yu, Waters Corporation, Milford MA 01757 Introduction +4S +3S Neutral +1S +2S +3S Erythropoietin (EPO) was purchased from European Pharmacopeia (reference material…

Improving Chromatographic Separations Of Biopharmaceuticals With MaxPeak High Performance Surfaces (HPS) Technology Analytical Solutions Using MaxPeak High Performance Surfaces (HPS) Technology for Biopharmaceutical Therapeutics Biopharmaceutical therapeutics have consistently been the fastest growing segment within the pharmaceutical space and require advances…

Application Note Improving Released N-glycan Analysis in Biotherapeutic Development Using the ACQUITY Premier Solution with MaxPeak High Performance Surfaces (HPS) Technology Ximo Zhang, Jacob Kellett, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Characterization and monitoring of glycosylation are…

Application Note Increased Resolving Power for Acidic Glycans with an MS-Compatible Anion Exchange Reversed Phase Separation Xiaoxiao Liu, Matthew A. Lauber Waters Corporation Abstract Glycosylation are often assigned as critical quality attributes in certain biotherapeutics because they can affect stability,…