USING HYBRID ORGANIC/INORGANIC SURFACE TECHNOLOGY TO MITIGATE ANALYTE INTERACTIONS WITH METAL SURFACES IN UPLC SEPARATIONS OF SMALL MOLECULE PHARMACEUTICALS

THE IMPORANCE OF MITIGATING ANALYTE INTERACTIONS WITH METAL SURFACES IN HPLC SEPARATIONS OF SMALL MOLECULES Thomas H. Walter, Bonnie A. Alden, Kenneth Berthelette, Cheryl Boissel Waters Corporation, Milford, MA 01757 INTRODUCTION RESULTS AND DISCUSSION Interactions of certain analytes with metal…

Application Note ACQUITY PREMIER Solution Improves the UPLC-MS Analysis of Deferoxamine – an Iron Chelating Drug Cheryl Boissel, Thomas H. Walter, Stephen J. Shiner Waters Corporation Abstract HPLC separations of metal-sensitive analytes are known to be impacted by interactions of…

MaxPeak Premier Columns Small Molecule Application Notebook CONTENTS Introduction Non-Specific Adsorption: Unwanted Interactions................................................................................... 3 How Do Scientists Solve This Problem Today?......................................................................................... 4 Precision Chemistry for Particles and Surfaces........................................................................................ 5 Fundamentals Waters™ Premier Standards to Investigate the Inertness of Chromatographic Systems....................................................................................................................................7…

[ WHITE PAPER ] Low Adsorption UPLC Systems and Columns Based on MaxPeak High Performance Surfaces: The ACQUITY Premier Solution T. H. Walter, M. Trudeau, J. Simeone, P. Rainville, A. V. Patel, M. A. Lauber, J. Kellett, M. DeLano, K.…