Developing Robust and Efficient IEX Methods for Charge Variant Analysis of Biotherapeutics Using ACQUIT Y UPLC H-Class System and Auto•Blend Plus

BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…

Characterization of Biotherapeutics: ACQUITY UPLC H-Class Bio with 2D Part 2 of 3: Rendering a Viable Interface for IEX with ESI-MS Analysis Robert Birdsall, Sean M. McCarthy, and Weibin Chen Waters Corporation, Milford, MA, USA A P P L I…

MAIN MENU TABLE OF CONTENTS [ APPLICATIONS NOTEBOOK ] BIOSEPARATIONS Tools, Techniques, and Insights into Biopharmaceutical Analysis INT RODUCTION Biopharmaceuticals have emerged as a dominant class due to their specificity and efficacy. T he production of biopharmaceuticals, however, is distinctly…

[ APPLICATION NOTE ] Auto•Blend Plus Technology for Ion-Exchange Chromatography Method Development and Robustness Testing Hua Yang, Bill Warren, and Stephan Koza Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ INTRODUCTION Auto•Blend™ Plus Technology Ion-exchange chromatography (IEX) is widely used…