Mass Spectrometric Characterization of Antibody-RNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q-TOF

Application Note Pharma & Biopharma Mass Spectrometric Characterization of Antibody-siRNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q‑TOF Author David L. Wong Agilent Technologies, Inc. Abstract Small interfering RNAs (siRNAs) are a promising type of RNA-based therapeutic drugs that demonstrate effectiveness…

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…

Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…

Poster Reprint ASMS 2021 Poster number ThP003 Characterization of Antibody-Drug Conjugates (ADC) using 2-Dimension Liquid Chromatography (2D-LC) and Native Mass Spectrometric Technologies David L. Wong and Sarah M. Stow Agilent Technologies, Inc., Santa Clara, CA, USA Introduction Antibody drug conjugates…