Peptide Mapping on Monoclonal Antibodies Using Agilent 6545XT AdvanceBio LC/Q-TOF and Protein Metrics Byos Software

Application Note Biotherapeutics Quantitation of Chemical-Induced Deamidation and Oxidation on Monoclonal Antibodies Using Agilent 6545XT AdvanceBio LC/Q-TOF and Agilent MassHunter BioConfirm Software Author Linfeng Wu Agilent Technologies, Inc. Santa Clara, CA, USA Introduction Modifications such as asparagine (Asn) deamidation, aspartate…

Application Note Biopharma/Pharma Peptide Mapping and Quantitation of Oxidation and Deamidation in Monoclonal Antibodies Author Yulan Bian Agilent Technologies, Inc. Abstract This application note demonstrates an integrated workflow of peptide mapping and quantitation of chemical-induced oxidation and deamidation in monoclonal…

Agilent-NISTmAb Peptide Mapping Agilent BioHPLC Columns Application Compendium Contents Agilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted from NISTmAb RM 8671 batch. Quality control (QC) testing is performed using Agilent LC-MS system. QC batch release test includes aggregate profile, charge variants…

Biopharma Compendium Accelerate Your CQA Efficiency and Approach it with Multi-Attribute Methodology Breakthroughs to Increase the Efficiency of Critical Quality Attribute (CQA) Testing and Allow for a Multi- Attribute Method (MAM) Production of therapeutic monoclonal antibodies (mAbs) relies on living…