A Novel Approach in HPLC Chiral Method Development: Dealing with Multiple Chiral Centers

Basics of Chiral HPLC Definitions Principles Available CSPs Mobile phase types T408109 sigma-aldrich.com The Field of Stereochemistry 1. All isomers have same chemical formula but differ in the arrangement of certain chemical groups in space. 2. Many types of isomers…

Supelco Columns for USP Methods The official pharmaceutical analysis monographs in the United States Pharmacopeia (USP) detail the methods used by pharmaceutical manufacturers for quality control of bulk drug substances and dosage form preparations. Each method specifies a particular high…

HPLC Enantiomeric Separations of Pharmaceuticals Using Polar Organic Mobile Phases •J.T. Lee and William Campbell Supelco, Div. of Sigma-Aldrich, Bellefonte, PA 16823 USA sigma-aldrich.com T411054 Agenda • • • • • • • • • Background Benefits Mechanisms Separation Comparisons…

Sigma-Aldrich Integrated Chiral Services • Paul Rodwell and Thierry Bonnaud Chirality 2012 Fort Worth, Texas, 10th-13th June Agenda • • • • • • • • Introduction Sigma-Aldrich Integrated Chiral Services Capability SAFC Pharmorphix® Chiral Services Overview Chiral Method Development…