Quantitation by High Resolution Mass Spectrometry: Using Target Enhancement and Tof-MRM to Achieve Femtogram-level On-column Sensitivity for Quantitation of Drugs in Human Plasma

Exploring Extra Sensitivity Using ionKey/MS with the Xevo G2-XS QTof HRMS for Small Molecule Pharmaceutical Analysis in Human Plasma Yun Wang Alelyunas, Mark D. Wrona, Jim Murphy, Angela Doneanu, Gregory Roman, and Paul Rainville Waters Corporation, Milford, MA, USA A…

Determination of Mass Resolution, Sensitivity, and Linear Dynamic Range of Small Molecules in Human Plasma Using ACQUITY UPLC I-Class and Xevo G2-S QTof Yun Alelyunas, Craig Dorschel, Mark Wrona, and Paul Rainville G OA L The sensitivity of the high…

[ ion key / MS ] APPLICATION COMPENDIUM Dear Colleague, The 2014 introduction of the ionKey/MS System was a turning point for LC-MS. The promise of increased levels of sensitivity from smaller sample sizes was finally a reality. We were…

High Sensitivity Bioanalysis for Small Drug-Like Compounds in Human Plasma using Microflow LC and High Resolution Mass Spectrometry Yun Wang Alelyunas, Mark Wrona, Jim Murphy, Kelly Doering Waters Corporation, Milford, Massachusetts, USA Abstract Introduction. Bioanalysis to support PK-PD studies and…