Importance of Selectivity for Reaction Monitoring

INVESTIGATING THE IMPLEMENTATION OF CONVERGENCE CHROMATOGRAPHY FOR MEDICINAL CHEMISTRY AND PROCESS DEVELOPMENT LABORATORIES Michael D. Jones1, Sean M. McCarthy1, James McKearin2, Jon Kremsky2, Andy Aubin1, Paula Hong1, and Margaret Maziarz1 1. Waters Corporation, 34 Maple Street, Milford, MA 01757; 2.…

Enantiomeric and diastereomeric separations of fragrance and essential oil components using the ACQUITY UPC 2 System with ACQUITY UPC 2 Trefoil Columns John P. McCauley and Rui Chen Waters Corporation, Milford, MA, USA A P P L I C AT…

[ APPLICATION NOTEBOOK ] IMPURITIES Developing Safe and Effective Drugs INT RODUCTION NAVIGATION T he pharmaceutical industry is integral in maintaining public health by providing therapeutic and preventative medicines. T he cornerstones of bringing new medicines to market are quality,…

Reaction Monitoring of a Rosuvastatin Synthesis Featuring Enantiopurity Determination by ACQUITY UPC,2 ACQUITY QDa, and Trefoil Column Technology Jacob N. Fairchild1 and Michael D. Jones1,2 1 Waters Corporation, Milford, MA, USA; 2 King’s College London, London, UK A P P…