A Stress Testing Study of Glimepiride Drug Substance Utilizing UPLC/MS Methodology

[ APPLICATION NOTEBOOK ] IMPURITIES Developing Safe and Effective Drugs INT RODUCTION NAVIGATION T he pharmaceutical industry is integral in maintaining public health by providing therapeutic and preventative medicines. T he cornerstones of bringing new medicines to market are quality,…

THE USE OF A TRIPLE DETECTION SYSTEM (UV, ELSD, MS) FOR PHARMACEUTICAL DEGRADATION STUDIES Paula Hong, Aaron Phoebe, and Patricia R. McConville Waters Corporation, 34 Maple Street, Milford, MA, USA, 01757 METHODS 0.60 3.50 0.0 0.0 6 6.50 5.0 95.0…

USE OF A TRIPLE DETECTION (UV-ELSD-MS) SYSTEM FOR MASS BALANCE IN FORCED DEGRADATION OF PHARMACEUTICALS Paula Hong and Patricia R. McConville INTRODUCTION RESULTS AND DISCUSSION Forced degradation studies are typically performed using HPLC and UV detectors to understand the degradation…

USE OF A TRIPLE DETECTION (UV-ELSD-MS) SYSTEM FOR MASS BALANCE IN FORCED DEGRADATION OF PHARMACEUTICALS Paula Hong and Patricia R. McConville INTRODUCTION RESULTS AND DISCUSSION Forced degradation studies are typically performed using HPLC and UV detectors to understand the degradation…