High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Permeability Assays

High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Permeability Assays Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction During the drug discovery process, permeability assays such as Caco-2 (cell line) and PAMPA (parallel artificial membrane…

Proven. Rapid. Complete. Agilent RapidFire 400 high-throughput mass spectrometry system 2 Leverage over 14 Years of User-Driven Product Innovation and Proven Application Success Do you want to open new avenues for pursuing small- and large-molecule targets— without using surrogates, radioactivity,…

Application Note Drug Discovery Ultrafast Analysis of Metabolic Stability Assays Using Agilent RapidFire High-Resolution MS Authors Michelle V. Romm, Nikunj Parikh, and Vaughn P. Miller Agilent Technologies, Inc. Wakefield, MA Yuqin Dai Agilent Technologies, Inc. Santa Clara, CA Abstract The…

High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as…