SFC Analytical to Preparative Scale Up of Similar Compounds with Torus DIOL 1.7 μm and 5 μm Columns: Separation of Benzoic Acid and Derivatives

[ APPLICATION NOTE ] Mass Directed SFC Purification Using ACQUITY QDa: Torus 2-PIC Separation of Goldenseal Alkaloids Kenneth D. Berthelette and Thomas Swann Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Prep SFC-MS method for mass-directed Natural products…

[ APPLICATION NOTE ] A Comparative Study Using Preparative Reverse Phase Liquid Chromatography and Supercritical Fluid Chromatography of Impurities from a Stressed Pharmaceutical Drug Substance Janet Hammond, 1 Russell Mortishire-Smith, 1 Jayne Kirk,1 and Christopher Howson 2,3 Waters Corporation, Wilmslow,…

UPC 2 Strategy for Scaling from Analytical to Preparative SFC Separations Christopher J. Hudalla, Abhijit Tarafder, Jo-Ann Jablonski, and Kenneth J. Fountain Waters Corporation, Milford, MA, USA A P P L I C AT I O N B E N…

UPC 2 Strategy for Scaling SFC Methods: Applications for Preparative Chromatography Christopher J. Hudalla,1 Abhijit Tarafder,1 Jo-Ann Jablonski,1 Roman Roshchin,1 Kenneth J. Fountain,1 Manisha A. Patel,2 Mark A. Hardink,2 Tony Yan,2 and Frank W. Riley2 1 Waters Corporation, Milford, MA,…