LC-UV-MS-based Synthetic Peptide Identification and Impurity Profiling Using the ACQUITY QDa Detector with ProMass Software

[ TECHNOLOGY BRIEF ] An Integrated LC-MS Workflow with ProMass HR for Synthetic Peptide Impurity Analysis Ximo Zhang, William R. Alley, Robert E. Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA High-resolution characterization of synthetic peptide impurities using…

[ APPLICATION NOTE ] Synthetic Peptide Characterization and Impurity Profiling Using a Compliance-Ready LC-HRMS Workflow Nilini Ranbaduge and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ A compliance-ready solution for peptide Peptide-based therapeutics are alpha amino…

[ APPLICATION NOTEBOOK ] ACQUITY QDa Detector QC APPLICATIONS COMPENDIUM EDITION 2 Dear Colleague The 2013 introduction of the ACQUITY™ QDa™ Detector was a breakthrough in Chromatography and Mass Spectrometry integration. It was the fulfilment of a vision 20 years…

[ APPLICATION NOTE ] Developing a Novel, Integrated LC-MS Workflow for High-resolution Monitoring and Characterization of Oligonucleotides Henry Shion, Robert Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Optimized RP-UPLC mobile phase Methods that…