Evaluating HPLC, UHPLC, and UPLC System Performance Using a Reversed-Phase Method for Peptides

[ APPLICATION NOTE ] Evaluating the Performance of the ACQUITY Arc Bio UHPLC System for the Size-Exclusion Chromatography Analysis of a Monoclonal Antibody Corey E. Reed, Stephan M. Koza, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…

[ APPLICATION NOTE ] Evaluating the Impact of LC System Dispersion on the Size-Exclusion Chromatography Analysis of Proteins Stephan M. Koza, Corey E. Reed, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Understanding the measurement Size-exclusion…

[ WHITE PAPER ] Dwell Volume and Extra-Column Volume: What Are They and How Do They Impact Method Transfer? Paula Hong and Patricia R. McConville Waters Corporation, Milford, MA, USA A chromatographic separation is impacted by numerous factors, including the…

[ APPLICATION NOTEBOOK ] SIZE-EXCLUSION CHROMATOGRAPHY (SEC) OF PEPTIDES, PROTEINS, AND AAVs [ SIZE-EXCLUSION CHROMATOGRAPHY ] [ SIZE-EXCLUSION CHROMATOGRAPHY ] Introduction Gel-permeation chromatography (GPC), size-exclusion chromatography (SEC), and gel-filtration chromatography (GFC) are commonly used terms to describe a liquid chromatographic…