PEPTIDE MAPPING: BEST PRACTICES FOR GENERATING RELIABLE AND ROBUST LIQUID CHROMATOGRAPHY METHODS

[ APPLICATION NOTE ] Performance of the ACQUITY UPLC I-Class PLUS System for Methods which Employ Long, Shallow Gradients Jennifer Simeone, Paula Hong, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Repeatable retention time delivery One…

[ APPLICATION NOTE ] Performance Comparison of Binary Ultra High Performance Liquid Chromatography Systems from Multiple Vendors for Methods Which Utilize Long, Shallow Gradients Jennifer Simeone, Paula Hong, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION…

Application Note Demonstrating the Applicability of the ACQUITY™ Premier Binary System for Long Shallow Gradient Peptide Mapping Analysis Corey E. Reed, Jennifer Simeone, Paula Hong Waters Corporation Abstract Reversed-Phase Liquid Chromatography (RPLC) is a key analytical tool in peptide mapping…

Evaluation of Pump Performance for Long Shallow Gradient Peptide Mapping Analysis Andrew Steere, Norris Wong, Paula Hong Waters Corporation, Milford, MA, 01757 RESULTS AND DISCUSSION INTRODUCTION Peptide mapping is a critical tool in biopharmaceutical analysis for characterization and impurity testing.…