A Semi-Automated Method for Sequencing Oligonucleotides using ISD and Pseudo-MS3 on a MALDI-Ion Trap-TOF Mass Spectrometer

Rapid-Turnaround Top-Down Sequence Verification and Characterization of Modified Proteins and Oligonucleotides Using a Benchtop MALDI-TOF/TOF Instrument Sinduri Vuppala1, Savannah Snyder1, Arndt Asperger2 1 Bruker Scientific LLC, Billerica, MA, USA 2 Bruker Daltonics GmbH & Co. KG, Bremen, Germany Results i)…

MALDI-TOF Mass Spectrometer MALDI-8020/MALDI-8030 Application News Amino Acid Sequencing of Synthetic Peptides Using a MALDI-TOF Mass Spectrometer and Protein Sequencer Kumiko Yamaguchi, Miho Akagi, and Tomoko Kuriki User Benefits  Amino acid sequences of peptides can be determined with the…

Next-generation MALDI top-down sequencing of protein biotherapeutics – expanding the scope of timsTOF technology Next-generation MALDI top-down sequencing (MALDI-TDS) improves top-down sequence analysis of biopharmaceutical proteins, as demonstrated in this note for adalimumab subunits, recombinant SARS-CoV-2 S-glycoprotein RBD expression products,…

Application News MALDI-TOF Mass Spectrometry Analysis MALDI-8030 Liquid Chromatograph Mass Spectrometer LCMS™-9030 Analysis of Oligonucleotide Therapeutics using MALDI-8030 and LCMS-9030 Y.Yamazaki User Benefits  Confident characterization of oligonucleotides  Elemental formula confirmation by ESI-QTOF  Information of sequence by MALDI-ISD…