Integrating a Chromatographic Separation for Removal of Lipids from Membrane Protein Samples into an Automated HDX MS Workflow

[ APPLICATION NOTE ] Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry Jing Fang, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION An enhanced-pressure (up to ~ 15,000 psi),…

ACQUITY UPLC M-Class System with HDX Technology Integration of Hydrogen Deuterium Exchange with High Resolution MS QUANT IF Y CHANGES IN P ROT EIN CONFORMAT ION W IT H CONFIDENC E The Waters ® ACQUITY UPLC ® M-Class System with…

[ TECHNOLOGY BRIEF ] Enhanced Performance of the SYNAPT XS and Its Impact on Hydrogen Deuterium Exchange Mass Spectrometry (HDX MS) Data Quality Lindsay Morrison, Malcolm Anderson, and Colette Quinn Waters Corporation, Milford, MA, USA The SYNAPT XS provides enhanced…

HIGHER SENSITIVITY, DATA QUALITY AND THROUGHPUT FOR HYDROGEN DEUTERIUM EXCHANGE EXPERIMENTS WITH EXTENDED ION MOBILITY SEPARATION Alexandre F. Gomes[1], Lindsay Morrison[1], Malcolm Anderson[2], Colette Quinn[1] [1] Waters Corporation, 34 Maple St., Milford, MA, 01757, USA [2] Waters Corporation, Stamford Avenue,…