HIGHER SENSITIVITY, DATA QUALITY AND THROUGHPUT FOR HYDROGEN DEUTERIUM EXCHANGE EXPERIMENTS WITH EXTENDED ION MOBILITY SEPARATION

Application Note Hydrogen Deuterium Exchange Coupled with SELECT SERIES Cyclic IMS Mass Spectrometer for Higher Workflow Efficiency Lindsay Morrison, Malcolm Anderson, Alexandre Gomes Waters Corporation For research use only. Not for use in diagnostic procedures. Abstract Hydrogen deuterium exchange is…

[ TECHNOLOGY BRIEF ] Enhanced Performance of the SYNAPT XS and Its Impact on Hydrogen Deuterium Exchange Mass Spectrometry (HDX MS) Data Quality Lindsay Morrison, Malcolm Anderson, and Colette Quinn Waters Corporation, Milford, MA, USA The SYNAPT XS provides enhanced…

OVERCOMING PEAK CAPACITY LIMITATIONS IMPOSED BY HYDROGEN EXCHANGE QUENCH CONDITIONS Bradley B. Stocks1, Thomas E. Wales1, Martha Stapels2, Keith Fadgen2, Michael Eggertson2, Geoff Gerhardt2, John R. Engen1 1Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA 2Waters Corporation, Milford…

[ APPLICATION NOTE ] Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry Jing Fang, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION An enhanced-pressure (up to ~ 15,000 psi),…