Noc vědy 2026 - Komunikace

Třetí den <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/all/events/930">27. Školy hmotnostní spektrometrie</a>, středa 23. září 2026, se dopoledne nesl ve znamení omických přístupů a metod, které posouvají možnosti běžné LC-MS analýzy. Zdeněk Spáčil otevřel program přehledem akvizičních strategií od full scanu a MS/MS přes DDA, DIA/SWATH a PRM/MRM až po HRMS, na který Jaroslava Friedecká navázala tématem společného vyhodnocování metabolomických, proteomických a lipidomických dat. Sekce „Za hranicemi rutinní MS“ pak ukázala další směry současné hmotnostní spektrometrie: Pavel Hrouzek představil využití stabilních izotopů při studiu metabolických drah, Robert Jirásko se zaměřil na iontovou mobilitu v LC/MS při analýze malých molekul a dopolední odborný blok uzavřela přednáška společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> věnovaná ionizační technologii <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/lcms/library?mainauthorItems=53&amp;search=SICRIT">SICRIT®</a>.Po intenzivním odborném programu přišlo na řadu tradiční kulturně-poznávací odpoledne. Účastníci si mohli vybrat mezi návštěvou Vyššího Brodu a tamního kláštera, výletem do Českého Krumlova spojeným s prohlídkou grafitového dolu, pěší túrou na Vítkův kámen nebo individuálním programem, jehož součástí byl také turnaj ve stolním fotbálku. Večer pak třetí konferenční den pokračoval společenským programem společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>, tentokrát v podobě Silent disco a tanečního večera.<h3>Program</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/program_Skola_MS_2026_final_8c8cf90056.pdf">Finální program 27. Školy MS je ke stažení zde</a></blockquote><h4>Středa, 23. 9. 2026</h4><h5>SEKCE VII. Od MS k omikám</h5><h5>08:30 – 09:15 Strategie akvizice v LC-MS: full scan vs. MS/MS, DDA vs. DIA (SWATH), PRM/MRM, HRMS&nbsp;</h5><ul><li>Zdeněk Spáčil&nbsp;</li></ul><h5>09:15 – 10:00 Kombinovaná analýza metabolomických, proteomických a lipidomických dat&nbsp;</h5><ul><li>Jaroslava Friedecká&nbsp;</li></ul><h5>10:00 – 10:30 Přestávka na kávu&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Waters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Phenomenex" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>SEKCE VIII. Za hranicemi rutinní MS&nbsp;</h5><h5>10:30 – 11:00 Od izotopové obálky k metabolickým drahám: využití stabilních izotopů při studiu primárního metabolismu a biosyntézy specializovaných metabolitů&nbsp;</h5><ul><li>Pavel Hrouzek&nbsp;</li></ul><h5>11:00 – 11:30 Současné techniky iontové mobility v LC/MS a jejich využití při analýze malých molekul&nbsp;</h5><ul><li>Robert Jirásko&nbsp;</li></ul><h5>11:30 – 12:00 <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>: SICRIT®: Nová dimenze v MS ionizaci&nbsp;</h5><ul><li>Jan Buček</li></ul><h5>12:00 – 13:30 Oběd&nbsp;</h5><h5>KULTURNĚ POZNÁVACÍ ODPOLEDNE&nbsp;</h5><ul><li>A Vyšší Brod – procházka městem, prohlídka kláštera&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg 233w," sizes="100vw" width="1600" height="1072"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg 208w," sizes="100vw" width="1600" height="1201"><ul><li>B Český Krumlov – prohlídka města, grafitový důl&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Návštěva grafitového dolu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg 207w," sizes="100vw" width="1600" height="1210"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Prohlídka města" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg 208w," sizes="100vw" width="1600" height="1200"><ul><li>C Vítkův kámen – pěší túra&nbsp;</li><li>D Individuální program&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>19:00 – 20:30 Večeře&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Večerní program" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>20:30 – ??? Společenský večer firmy <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> - Silent disco</h5><ul><li>Taneční večer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Společenský večer firmy Shimadzu - Silent disco" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg 245w," sizes="100vw" width="1600" height="900">

27. Škola MS 2026 - den 3

Nový grafenový inkoust pro výrobu levných a citlivých tištěných senzorů vyvinuli výzkumníci z CATRIN Univerzity Palackého ve spolupráci s kolegy z VŠB-Technické univerzity Ostrava a Univerzity Karlovy. Při přípravě inkoustu poprvé využili metodu atomárního inženýrství a díky navázaným atomům mědi jsou schopni detekovat velmi citlivě dopamin – neurotransmiter, který umožňuje přenos signálů mezi nervovými buňkami. Přístup <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">představený v časopise Advanced Science</a> má velké šance uplatnit se v lékařské diagnostice.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp 117w," sizes="100vw" width="1920" height="2560">Atomární inženýrství (single-atom engineering) umožňuje řídit chemickou reaktivitu materiálů na úrovni jednotlivých atomů. Jeho širšímu uplatnění v lékařské diagnostice však dosud bránil nedostatek atomárně upravených materiálů i absence na nich založených tisknutelných inkoustů.&nbsp;Nyní se vědcům podařilo vyvinout novou třídu atomárně dopovaných grafenových materiálů a také inkoust pro přípravu citlivých tištěných senzorů. Sázka na měď se vyplatila při detekci dopaminu, jehož sledování je důležité pro biomedicínský výzkum a vývoj pokročilých diagnostických technologií některých onemocnění včetně Alzheimerovy choroby.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp 117w," sizes="100vw" width="1920" height="2560">„Vyvinutý NGA-Cu inkoust umožňuje výrobu plně inkoustově tištěných udržitelných papírových elektrod s velmi nízkými náklady. Samotný senzor vyžaduje pouze 1,3 mikrogramu aktivního inkoustu, stojí přibližně jednu korunu a dával stabilní odezvu minimálně po dobu tří měsíců. Inkoust je navíc plně kompatibilní s běžně dostupnými inkoustovými materiálovými tiskárnami. To vytváří velký potenciál pro přípravu cenově dostupných, digitálně navržených senzorů, jejichž funkci lze přizpůsobovat atom po atomu,“ uvedl korespondující autor článku Michal Otyepka.Základem pro novou generaci atomárních inkoustů byla dusíkem dopovaná grafenová kyselina (NGA), kterou vědci z CATRIN vyvinuli před několika lety. Nyní ji postupně obohacovali různými jednotlivými atomy kovů včetně mědi, železa nebo manganu.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp 117w," sizes="100vw" width="1920" height="2560">„Ukázalo se, že elektrochemická odezva zásadně závisí na typu použitého atomu. Zatímco atomy mědi výrazně zesilují signál dopaminu, ostatní kovy jej naopak potlačují. Rozhodující&nbsp;tedy není jen samotná přítomnost izolovaných atomů kovu, ale také to, o jaký konkrétní kov se jedná. To je velmi důležitý poznatek pro další vývoj biosenzorů,“ objasnil první autor Martin-Alex Nalepa.Publikované výsledky představují novou třídu senzorických materiálů s velkým potenciálem v lékařské diagnostice. Vědci nabízí obecně využitelnou platformu pro vývoj grafenových inkoustů s jednotlivými atomy kovů a otevírají cestu ke škálovatelné, reprodukovatelné a materiálově úsporné výrobě pokročilých elektrochemických senzorů. „Jsme na začátku a fascinují nás nové možnosti, které se před námi otevírají. Vidíme, že změnou typu atomů můžeme řídit citlivost a selektivitu senzoru. Kromě dopaminu tak umíme velmi přesně stanovit například imunoglobuliny – protilátky, jejichž množství a typ mohou být důležitým ukazatelem autoimunitních nebo infekčních onemocnění,“ zdůraznil další z autorů článku Radek Zbořil.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp 117w," sizes="100vw" width="1920" height="2560">Elektrochemické biosenzory mohou nalézt uplatnění nejen v medicíně, ale také při kontrole kvality potravin, monitorování pitné vody nebo sledování znečištění životního prostředí. Jejich klíčovou součástí jsou funkcionalizované elektrody, pro jejichž výrobu se ukázaly jako velmi vhodné materiály právě na bázi grafenu. Základem úspěchu olomouckých vědců byla cílená příprava grafenového inkoustu s potřebnými vlastnostmi.Výzkum podpořil projekt TECHSCALE z operačního programu Jan Amos Komenský.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice: Projekt TECHSCALE (No.&nbsp;CZ.02.01.01/00/22_008/0004587) je financován z&nbsp;programu MŠMT&nbsp;OP&nbsp;JAK Špičkový výzkum, podpořeného z&nbsp;EFRR/ESF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg 245w," sizes="100vw" width="620" height="87"><blockquote><h4>Článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection</a></h4>Martin-Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendřišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal OtyepkaAdv. Sci., 2026, e76796<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/advs.76796">https://doi.org/10.1002/advs.76796</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>

Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice

Popularizace

Věda a výzkum

Video

Článek

Nejbližší akce

Škola hmotnostní spektrometrie je odborná vzdělávací akce pořádaná od roku 1986, která vedle zajímavých přednášek a kurzů nabízí i nespočet příležitostí k přátelským setkáním a diskusím.

Škola hmotnostní spektrometrie

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Noc vědců, akce oživující v jeden večer stovky vědeckých budov, do kterých se běžný smrtelník nedostane. Návštěvníci proplouvají laboratořemi, přednáškovými místnostmi, vybuchujícími experimenty a jdou do hloubky aktuálních témat. 

Noc vědců

Agilent Technologies

ACD/Labs

Petro Industry News

Thermo Fisher Scientific

Evosep Biosystems

Waters Corporation

Packaging materials, among them plastics, are now the focus of the circular economy. The recent legislation establishes the elimination of single use plastics and the use of a high percentage of recycled materials in the packaging, even in those used for food applications. Among the postconsumer plastics, PET has been taken as the primary objective for recycling and nowadays the recycling technologies for PET are well advanced, thus producing very high quality of rPET. However, the case of polyolefins is very different. In a recent study carried out in our lab, more than 450 substances were identified in rHDPE and many of them were above the acceptable limits for food contact. It is quite obvious that the use of recycled polyolefins is not ready yet.
The first principle is to guarantee the safety in use. But for this purpose, advanced analytical techniques are required, as the forest of peaks/substances released from the recycled polyolefins is still a nightmare. Usually, when analyzing the leachables/migration the problem is not to detect them, but to identify the individual substances and confirm their identity versus the corresponding standards. Unfortunately, many of the released chemicals don’t have standards available and thus, the confirmation and later quantification is not possible. New advanced techniques, such as ion mobility (IMS) in high resolution mass spectrometry and the use of libraries provide new tools for this purpose.
The presentation will show details of analytical methodology used, a few case studies and the available libraries containing more than 10,000 substances detected worldwide from packaging materials with the IMS data.
<blockquote>
Presenter: Cristina Nerin (Professor, Department of Analytical Chemistry, University of Zaragoza)
</blockquote>
<blockquote>
Full Professor at the University of Zaragoza (Spain), PhD in Analytical Chemistry, Master in Science (Analytical Chemistry) and Degree in Chemistry at the University of Zaragoza (Spain). Director of the Research Group GUIA at the University of Zaragoza and Director of the Master in Environmental Engineering at the University of Zaragoza from 1990 to 2012. Author of more than 395 Scientific Publications included in the Citation Index, Director of 38 PhD Thesis (5 more are in process). Principal Investigator of more than 240 Research Projects in both Competitive calls and also R&amp;D&amp;I with Industry Inventor in six International Patents dealing with active packaging and in one International Patent on Intelligent Packaging. All of them are in exploitation (market). Six Research Awards received. Participant in more than 140 International Conferences and Professor of several International Courses n Europe, Asia and South-America.
</blockquote>

Waters Corporation: How to Guarantee the Safety of Recycled Polyolefins for Food Contact

How to Guarantee the Safety of Recycled Polyolefins for Food Contact

Analytical methodology, case studies and the libraries containing more than 10,000 substances detected worldwide from packaging materials with the IMS data.

Safety of Recycled Polyolefins for Food Contact

Untargeted metabolomics provides an opportunity to interrogate a sample for systems biology and biomarker discovery for life science researchers.
Discussed here is a comprehensive untargeted analysis workflow for metabolomics.
Plasma samples from mouse models were processed using automated sample prep workflow and analyzed using HILIC chromatography and the 6546 LC/Q-TOF which provided high resolution, extended dynamic range, and isotopic fidelity for the highest confidence in identification. A custom and transferable MS/MS and retention time library for over 400 core metabolites was built for identification. When a true unknown was discovered, SIRIUS/CSI:FingerID software was used for identification based on the MS/MS fragment profile.
<blockquote>
Presenter: Karen Yannell (LC/MS Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Karen E. Yannell is a LC/MS Application Engineer at Agilent Technologies. She is an expert in small molecule high throughput analysis by triple quadrupole (TQ) and quadrupole time-of-flight (QTOF) mass spectrometry for applied markets. Her recent work has focused on developing routine Q-TOF workflows for both expert and non-expert users alike. Previously, Karen worked on forensic, metabolomics, and biomarker discovery applications with ambient ionization sources. She received her PhD in Analytical Chemistry from Purdue University where studied under the advisement of Prof. R. Graham Cooks. Outside of the laboratory, she enjoys cooking unique dishes and hiking along the beach with her dog.
</blockquote>

Agilent Technologies: Say “I Do” to New ID Tools: A Novel Untargeted Approach to Unveil the Metabolome

Say “I Do” to New ID Tools: A Novel Untargeted Approach to Unveil the Metabolome

Discussed here is a comprehensive untargeted analysis workflow for metabolomics.

A Novel Untargeted Approach to Unveil the Metabolome

Questions that are answered by structure elucidation and &amp; verification are integral parts of chemical R&amp;D workflows from discovery to development and manufacturing. But as scientists constantly strive to do their work faster and better, they must be careful to ensure that efficiency does not come at the cost of confidence in the determined structure.
Join us as we bring together experts from some of the industry’s leading organizations to share how they leverage software to make the most of their NMR, LC/MS, and GC/MS data and boost their structure elucidation and verification workflows.
<h5>Who won’t want to miss this symposium?</h5>
<ul>
<li>Synthetic and medicinal chemists responsible for elucidating and verifying the structures of their reaction products and by-products Natural products researchers
</li>
<li>Members of structure elucidation groups
</li>
<li>Decision makers at institutions where chemical structures need to be identified quickly and confidently
</li>
</ul>
<h3>Event Agenda</h3>
<h5>15:30-16:10 (CEST) Novartis CSI: Detectives in the Chemistry Lab</h5>
<ul>
<li>Dorina Kotoni (Associate Director/Chemical Structure Investigation Group Lead, Novartis)</li>
</ul>
<h5>16:15-16:50 (CEST) Structure Elucidation at Pfizer Sandwich</h5>
<ul>
<li>John Baker (Principal Scientist, Pfizer)</li>
</ul>
<h5>16:55-17:30 (CEST) A Chemical Characterization Workflow to Speed up Identification of Unknowns</h5>
<ul>
<li>Cindy Roberson (Principal Scientist, Medtronic)</li>
<li>Joe Buchman (Senior Chemist, Medtronic)</li>
</ul>

ACD/Labs: What's That Peak? Structure Elucidation & Verification Virtual Symposium 

What's That Peak? Structure Elucidation & Verification Virtual Symposium

What’s in my sample? Did I make what I think I made? What’s that peak?

What's That Peak? Structure Elucidation & Verification

Questions that are answered by structure elucidation and &amp; verification are integral parts of chemical R&amp;D workflows from discovery to development and manufacturing. But as scientists constantly strive to do their work faster and better, they must be careful to ensure that efficiency does not come at the cost of confidence in the determined structure.
Join us as we bring together experts from some of the industry’s leading organizations to share how they leverage software to make the most of their NMR, LC/MS, and GC/MS data and boost their structure elucidation and verification workflows.
<h5>Who won’t want to miss this symposium?</h5>
<ul>
<li>Synthetic and medicinal chemists responsible for elucidating and verifying the structures of their reaction products and by-products Natural products researchers
</li>
<li>Members of structure elucidation groups
</li>
<li>Decision makers at institutions where chemical structures need to be identified quickly and confidently
</li>
</ul>
<h3>Event Agenda</h3>
<h5>15:30-16:10 (CEST) Combined LC/MS and NMR for Automated Verification of Chemical Structures</h5>
<ul>
<li>Celine Nguyen-Van-Dau (Head of Integrated Drug Discovery (IDD) Structural Analysis team, Sanofi)</li>
</ul>
<h5>16:15-16:50 (CEST) Pharmaceutical Discovery and Development Analytical Workflows</h5>
<ul>
<li>Kevin Robbins (Associate Principle Scientist, AstraZeneca)</li>
</ul>
<h5>16:55-17:30 (CEST) Conformational Analysis of Peptidomimetic Drug Leads by NMR</h5>
<ul>
<li>Purnima Khandelwal (Senior Principal Scientist, Small Molecule Drug Discovery, Bristol Myers Squibb)</li>
</ul>
<h5>Hosted By</h5>
<ul>
<li>Sanji Bhal (Director, Marketing Communications (ACD/Labs))</li>
<li>Sarah Srokosz (Marketing Communications Specialist (ACD/Labs))</li>
</ul>

Peptide fractionation is important in proteomics workflows to reduce sample complexity and increase the separation efficiency. This leads to increased dynamic range of the identified peptides compared to conventional single-shot analysis.
The additional number of injections per fractionated sample is a good match with the short overhead time between injections on the Evosep One.
<h4>Optimal analytical strategies for sensitive and quantitative phosphoproteomics using TMT-based multiplexing</h4>
<ul>
<li>Presenter: Claire Koenig (CPR)</li>
</ul>
Combination of isobaric labeling (TMTs) coupled with offline high-pH fractionation can maximize analysis depth in quantitative phosphoproteomics analysis. To investigate to what extent sample amount affect the sensitivity and the dynamic range of the analysis, we benchmark strategies for quantitative phosphoproteomics with limited peptide input amounts. Based on this research, we present a decision tree to guide phosphoproteomics users to find the best workflow, to reach optimal depth of coverage, based on experimental design and peptide availability.
More to be announced

Fractionation

Peptide fractionation is important in proteomics workflows to reduce sample complexity and increase the separation efficiency. 

Ensuring the safety and efficacy of biotherapeutics from research to development, and then from manufacturing to quality control is essential in order to bring a product to market. Large molecules pose unique challenges for biotherapeutic analyses in that they often requires running a panel of tests to ensure product efficacy and safety. Industry efforts have evolved towards comprehensive analytical workflows that enable researchers to monitor their purity, potency, and critical quality attributes (CQAs) of highly complex and diverse biotherapeutic molecules.
This session will outline the basics of the biopharmaceutical industry and the analytical tools utilized to access the quality and purity of their products. 
<h5>Learning Objectives:</h5>
<ul>
<li>Describe the phases of biotherapeutic &#39;pipeline&#39;</li>
<li>Discuss the various modalities that encompass the biopharmaceutical industry and the analytical tools that routinely used to access the quality of these modalities.</li>
<li>Learn the Quality by Design (QbD) approach in the development of biopharmaceutical products and process parameters to access product critical quality attributes (CQA)</li>
</ul>
<blockquote>
Presenter: Christopher M. Colangelo, PhD, MBA (Biopharma Business Development Leader, Americas, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Christopher Colangelo, PhD, MBA is the Agilent Biopharma Business Development Leader for the Americas. Prior to joining Agilent, he was the 5th employee and co-inventor of the 454-sequencing platform. In 2003, Chris joined Yale University as a Research Faculty in where he mentored and supervised a research group producing 60+ peer-reviewed publications and directed core research laboratories for four NIH P30 grants, totaling over $21 million worth of research funds. In 2017, Chris joined Agilent to help customers develop, test, and implement end-to-end biopharma workflows.
</blockquote>

Agilent Technologies: Overview of Analytical Tools for Developing the Next Generation of Biopharmaceuticals

Overview of Analytical Tools for Developing the Next Generation of Biopharmaceuticals

This session will outline the basics of the biopharmaceutical industry and the analytical tools utilized to access the quality and purity of their products. 

Developing the Next Generation of Biopharmaceuticals

This webinar will discuss considerations for adaptation and optimization of an AAA pre-column derivatization method from UPLC to HPLC/UHPLC. The following topics will be examined:
<ul>
<li>Shorter run times (i.e., higher throughput and lower solvent consumption) using a new column for AAA vs. traditional HPLC methods</li>
<li>How to accurately separate, identify, &amp; quantify amino acids in cell culture, protein hydrolysates, foods, and feeds </li>
<li>Scaling of AccQ·Tag Ultra UPLC methods for analysis on HPLC systems, including Waters Arc HPLC and ACQUITY Arc Chromatography Systems</li>
</ul>
<h5>Key learning objectives:</h5>
<ul>
<li>How to accurately separate, identify, &amp; quantify amino acids in cell culture, protein hydrolysates, foods, and feeds</li>
<li>Scaling of proven AccQ·Tag Ultra UPLC methods for analysis on HPLC systems, including Waters Arc HPLC and ACQUITY Arc Chromatography Systems</li>
</ul>
<blockquote>
Presenter: Paula Phenix (Principal Product Marketing Manager, Waters Corporation)
</blockquote>
<blockquote>
Paula Phenix is a Principal Product Marketing Manager in the Chemistry and Automation Group at Waters Corporation, where she has been for three years. Prior to the Chemistry and Automation Group, she was a Principal Product Marketing Manager in the LC Instruments Product Management team.
</blockquote>
<blockquote>
Presenter: Kimberly Martin (Evaluation Scientist II, Waters Corporation)
</blockquote>
<blockquote>
Kimberly Martin is part of the System Design and Development Team at Waters Corporation and serves as an Evaluation Scientist II that verifies, validates and tests new instrumentation and products. She has been the company for over 4 years. She has a total of 13 years of analytical chemistry experience including polymer chemistry, food and environmental chemistry, and pharmaceutical chemistry. Kimberly has extensive experience in HPLC, LCMS, GCMS, GC-FID, additional MS technologies and sample preparation.
</blockquote>

Waters Corporation: Updating your HPLC Method for Amino Acid Analysis to Save Time Compared to Traditional HPLC

Updating your HPLC Method for Amino Acid Analysis to Save Time Compared to Traditional HPLC

This webinar will discuss considerations for adaptation and optimization of an AAA pre-column derivatization method from UPLC to HPLC/UHPLC.

Updating your HPLC Method for Amino Acid Analysis

Monitoring the quality of hydraulic and/or lube oils is critical to prevent premature wear of any kind of machinery. In this session we will look at this topic from a new perspective focusing on the combination of titration (potentiometric, thermometric, coulometric Karl Fischer titration) and Vis-Near-Infrared Spectroscopy (Vis-NIRS).
Combining titration (highly sensitive, specific, a widely used primary method) with Vis-NIRS (fast, non-destructive, results for multiple parameters at once) can make your oil condition monitoring and/or lubricant analysis much more efficient, especially, if your laboratory has to analyze large sample series every day.
Attending this session, you will learn and understand:
<ul>
<li>The specific advantages of each method (titration and Vis-NIR-Spectroscopy)</li>
<li>How and when to use these methods to measure critical chemical and physical parameters in lube and hydraulic oils</li>
<li>What thermometric titration is and how it helps to improve robustness of serial acid number testing</li>
<li>How to automate measurements of large sample series to increase efficiency and reproducibility</li>
<li>How Vis-NIRS for lubricant analysis complies with ASTM guidelines and can save costs and time</li>
</ul>
<blockquote>
Presenter: Robert Tobler (Application Specialist Titration)
</blockquote>
<blockquote>
Robert Tobler studied chemistry at the Zurich University of Applied Science in Wädenswil, Switzerland. He joined Metrohm in 2015 as an application specialist titration. Since 2018 he has also been involved in stability measurement.
</blockquote>
<blockquote>
Presenter: Nicolas Rühl, PhD (Product Manager Spectroscopy)
</blockquote>
<blockquote>
Dr. Nicolas Rühl is working in the Competence Center Spectroscopy since 2015. In this time, he has been in charge of developing the near-infrared (NIR) spectroscopy business at Metrohm. Nicolas has a Master in Business Administration and received his PhD in physical chemistry on single-molecule spectroscopy using Vis-NIR and Raman spectroscopy technologies.
</blockquote>
<blockquote>
Moderator: Tom Lynch CChem FRSC (Independent Analytical Consultant, International Labmate)
</blockquote>
<blockquote>
Tom has 35 years of experience in the petroleum industry, specialising in the delivery of forensic and problem solving /method development capabilities for BP Fuels and Lubricants businesses globally. He was also a member of the BP Science Council representing Analytical Science and led a BP wide Analytical Science network.Tom has published over 30 citable papers, 4 book chapters and has given over 60 presentations at conferences. He is a past Vice President of the Royal Society of Chemistry (RSC) Analytical Division and a past Chairman of the RSC Separation Science Group. In addition, Tom is a recipient of the Silver Jubilee Medal by the Chromatographic Society and a technical achievement award by the Energy Institute.
</blockquote>

Metrohm: Making your quality control of hydraulic and lube oils more efficient

Making your quality control of hydraulic and lube oils more efficient

Combining titration and Vis-Near-Infrared Spectroscopy for higher sample throughput & faster results

Efficient quality control of hydraulic and lube oils

Extracting sold samples, like soil, for environmental contaminants has always been a challenge. Using manual techniques like Soxhlet, are time-consuming, laborious and costly due to the amount of effort dedicated to sample prep as well as the high volume of solvents used. Additionally, manual processes can be error-prone which can lead to rerunning samples or the need to resample all together. While there are instruments available for automated sample preparation steps, the entire workflow has not been able to be done by just one device. Most instruments process samples one at a time, therefore, take a long time to prepare samples. Plus, user intervention is required to move samples between the extraction and evaporation devices.
Discover the Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor which boosts sample prep productivity, and efficiency, and brings a new level of consistency. Introducing the first walk-away sample preparation instrument. The EXTREVA ASE system combines extraction, in-cell cleanup, and evaporation into one seamless operation without the need for user intervention. Parallel sample extraction and evaporation without the need to interact with the instrument will allow you to fully dedicate your time and attention to more important value added tasks without having to worry about your sample extraction and concentration.
<blockquote>
Presenter: Chris Shevlin (Scientific and Educational Affairs Manager, IC/SP, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Chris Shevlin is the Scientific and Educational Affairs Manager for Ion Chromatography and Automated Sample Preparation systems at Thermo Fisher Scientific. After graduating from the University of Buffalo, he started working in a pharmaceutical laboratory running HPLC, LC-MS and other chromatographic methods in a technical services and QC laboratory. After earning an MBA in 2004, Chris has worked in sales, product management and marketing with a few of the major analytical instrument manufacturers.
</blockquote>
<blockquote>
Presenter: Rahmat Ullah (Manager, Chemistry, IC/SP, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Rahmat Ullah has been working for over 15 years in the sample preparation field with the Ion Chromatography and Sample Preparation (IC/SP) business unit at Thermo Fisher Scientific. He holds a Ph.D. degree in Chemistry. Rahmat is currently leading the Sample Preparation team in the design, development, and application efforts related to sample preparation platforms offered by IC/SP.
</blockquote>
<blockquote>
Presenter: Jingli Hu (Sr. Product Applications Specialist, IC/SP, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Jingli is a Staff Applications Scientist at Thermo Fisher Scientific. She has been with Thermo Fisher Scientific for seven years. Here she is currently focusing on liquid chromatography and sample preparation applications within the food, environmental, and biopharma markets. Prior to joining Thermo Fisher Scientific, she built seven years of R&amp;D lab experience in the food and pharmaceutical industries.
</blockquote>
<blockquote>
Presenter: Sandra Rontree (Senior Manager, Product Marketing Ion Chromatography/ Sample Preparation &amp; Discrete Industrial Analyzer, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Sandra Rontree is leading a team of product marketing managers for Ion Chromatography and Sample Preparation in the Chromatography and Mass Spectrometry group at Thermo Fisher Scientific Inc. She has built her career in a variety of roles at the leading pharmaceutical and scientific instrument vendor organizations where she was a scientific researcher, business development and marketing manager. Sandra has more than 20 years’ experience with analytical instrumentation and has a strong interest in HPLC, GC, IC and Mass Spectrometry. She is passionate about creating marketing strategies and collaborating with customers utilizing innovative technology to address their needs. Sandra holds a degree in Chemical Engineering and received her PhD from the Bielefeld University in Organic Chemistry and Mass Spectrometry.
</blockquote>

Thermo Scientific: Walkaway sample-to-vial sample preparation with the EXTREVA ASE system

Walkaway sample-to-vial sample preparation with the EXTREVA ASE system

Discover the Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor which boosts sample prep productivity, and efficiency.

Sample preparation with the EXTREVA ASE system

Welcome to the 2022 Detection and Quantification of PFAS in Air, Water, Soil, and Food Packaging e-learning series.
In the third event of our three-part eSeminar series, a leading expert in PFAS analysis will discuss a variety of topics around PFAS in food packaging materials, including method development and sample preparation.
A non-intentionally added substance or NIAS, in packaging is an issue of growing concern. First mentioned in EU Regulation 10/2011, predictable and unpredictable NIAS, in the form of degradation products and impurities, were found not only in plastic but also in paper and in newly developed materials, such as recycled and biobased packaging.
In the case of recycled materials, there is a new type of NIAS, which comes from recycling cycles: an accumulation of different mixture of chemicals might occur when materials are recycled many times. The prediction, identification and control of NIAS in recycled materials is therefore challenging because of the difficulty tracing their origin.
Due to the complex identification of the contamination pathway, chemicals like PFAS can be considered to be both intentionally and non-intentionally added. Some PFAS molecules are included for use and find market applications in food contact materials due to their grease- and water-proof properties. In this case they are intentionally added. This is frequent in paper packaging; and when this also has a recycled content, PFAS can be present as NIAS, originating from the intentionally added PFAS in the recycled paper fibres, or from inks, for example. 
Environmental contamination should also not be ignored, where PFAS can be introduced in paper packaging from water used during the recycling or manufacturing process or from the atmosphere. 
Distinguishing between these sources is important: new instrumental technologies and approaches are needed, not only for analytical efficiency and for performance, but also to open up the identification and quantification of what is predictable and what is not.
<blockquote>
Presenter: Andrea Vittadello (Project Manager-Sustainability, Mérieux NutriSciences Food Science Center)
</blockquote>
<blockquote>
Andrea Vittadello co-ordinates the group of Project Managers in Mérieux NutriSciences Food Science Center and is himself Project Manager for the Sustainability area. He has been part of this laboratory since 2002 and has been involved almost immediately in biodegradability studies. He is a member of the European Bioplastics Technical Committee and the BPI Committee on Standards and Procedures. He is also currently Convenor at two CEN groups for Specific and Global Migrations, and of a UNI committee on Food Contact Materials.
</blockquote>

PFAS: A package deal

We will discuss a variety of topics around PFAS in food packaging materials, including method development and sample preparation.

Fractionation

Making your quality control of hydraulic and lube oils more efficient

Say “I Do” to New ID Tools: A Novel Untargeted Approach to Unveil the Metabolome

Updating your HPLC Method for Amino Acid Analysis to Save Time Compared to Traditional HPLC

Overview of Analytical Tools for Developing the Next Generation of Biopharmaceuticals

What's That Peak? Structure Elucidation & Verification Virtual Symposium

Walkaway sample-to-vial sample preparation with the EXTREVA ASE system

PFAS: A package deal

How to Guarantee the Safety of Recycled Polyolefins for Food Contact

What's That Peak? Structure Elucidation & Verification Virtual Symposium

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