Noc vědy 2026 - Komunikace

Třetí den <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/all/events/930">27. Školy hmotnostní spektrometrie</a>, středa 23. září 2026, se dopoledne nesl ve znamení omických přístupů a metod, které posouvají možnosti běžné LC-MS analýzy. Zdeněk Spáčil otevřel program přehledem akvizičních strategií od full scanu a MS/MS přes DDA, DIA/SWATH a PRM/MRM až po HRMS, na který Jaroslava Friedecká navázala tématem společného vyhodnocování metabolomických, proteomických a lipidomických dat. Sekce „Za hranicemi rutinní MS“ pak ukázala další směry současné hmotnostní spektrometrie: Pavel Hrouzek představil využití stabilních izotopů při studiu metabolických drah, Robert Jirásko se zaměřil na iontovou mobilitu v LC/MS při analýze malých molekul a dopolední odborný blok uzavřela přednáška společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> věnovaná ionizační technologii <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/lcms/library?mainauthorItems=53&amp;search=SICRIT">SICRIT®</a>.Po intenzivním odborném programu přišlo na řadu tradiční kulturně-poznávací odpoledne. Účastníci si mohli vybrat mezi návštěvou Vyššího Brodu a tamního kláštera, výletem do Českého Krumlova spojeným s prohlídkou grafitového dolu, pěší túrou na Vítkův kámen nebo individuálním programem, jehož součástí byl také turnaj ve stolním fotbálku. Večer pak třetí konferenční den pokračoval společenským programem společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>, tentokrát v podobě Silent disco a tanečního večera.<h3>Program</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/program_Skola_MS_2026_final_8c8cf90056.pdf">Finální program 27. Školy MS je ke stažení zde</a></blockquote><h4>Středa, 23. 9. 2026</h4><h5>SEKCE VII. Od MS k omikám</h5><h5>08:30 – 09:15 Strategie akvizice v LC-MS: full scan vs. MS/MS, DDA vs. DIA (SWATH), PRM/MRM, HRMS&nbsp;</h5><ul><li>Zdeněk Spáčil&nbsp;</li></ul><h5>09:15 – 10:00 Kombinovaná analýza metabolomických, proteomických a lipidomických dat&nbsp;</h5><ul><li>Jaroslava Friedecká&nbsp;</li></ul><h5>10:00 – 10:30 Přestávka na kávu&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Waters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Phenomenex" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>SEKCE VIII. Za hranicemi rutinní MS&nbsp;</h5><h5>10:30 – 11:00 Od izotopové obálky k metabolickým drahám: využití stabilních izotopů při studiu primárního metabolismu a biosyntézy specializovaných metabolitů&nbsp;</h5><ul><li>Pavel Hrouzek&nbsp;</li></ul><h5>11:00 – 11:30 Současné techniky iontové mobility v LC/MS a jejich využití při analýze malých molekul&nbsp;</h5><ul><li>Robert Jirásko&nbsp;</li></ul><h5>11:30 – 12:00 <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>: SICRIT®: Nová dimenze v MS ionizaci&nbsp;</h5><ul><li>Jan Buček</li></ul><h5>12:00 – 13:30 Oběd&nbsp;</h5><h5>KULTURNĚ POZNÁVACÍ ODPOLEDNE&nbsp;</h5><ul><li>A Vyšší Brod – procházka městem, prohlídka kláštera&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg 233w," sizes="100vw" width="1600" height="1072"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg 208w," sizes="100vw" width="1600" height="1201"><ul><li>B Český Krumlov – prohlídka města, grafitový důl&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Návštěva grafitového dolu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg 207w," sizes="100vw" width="1600" height="1210"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Prohlídka města" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg 208w," sizes="100vw" width="1600" height="1200"><ul><li>C Vítkův kámen – pěší túra&nbsp;</li><li>D Individuální program&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>19:00 – 20:30 Večeře&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Večerní program" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>20:30 – ??? Společenský večer firmy <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> - Silent disco</h5><ul><li>Taneční večer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Společenský večer firmy Shimadzu - Silent disco" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg 245w," sizes="100vw" width="1600" height="900">

27. Škola MS 2026 - den 3

Nový grafenový inkoust pro výrobu levných a citlivých tištěných senzorů vyvinuli výzkumníci z CATRIN Univerzity Palackého ve spolupráci s kolegy z VŠB-Technické univerzity Ostrava a Univerzity Karlovy. Při přípravě inkoustu poprvé využili metodu atomárního inženýrství a díky navázaným atomům mědi jsou schopni detekovat velmi citlivě dopamin – neurotransmiter, který umožňuje přenos signálů mezi nervovými buňkami. Přístup <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">představený v časopise Advanced Science</a> má velké šance uplatnit se v lékařské diagnostice.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp 117w," sizes="100vw" width="1920" height="2560">Atomární inženýrství (single-atom engineering) umožňuje řídit chemickou reaktivitu materiálů na úrovni jednotlivých atomů. Jeho širšímu uplatnění v lékařské diagnostice však dosud bránil nedostatek atomárně upravených materiálů i absence na nich založených tisknutelných inkoustů.&nbsp;Nyní se vědcům podařilo vyvinout novou třídu atomárně dopovaných grafenových materiálů a také inkoust pro přípravu citlivých tištěných senzorů. Sázka na měď se vyplatila při detekci dopaminu, jehož sledování je důležité pro biomedicínský výzkum a vývoj pokročilých diagnostických technologií některých onemocnění včetně Alzheimerovy choroby.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp 117w," sizes="100vw" width="1920" height="2560">„Vyvinutý NGA-Cu inkoust umožňuje výrobu plně inkoustově tištěných udržitelných papírových elektrod s velmi nízkými náklady. Samotný senzor vyžaduje pouze 1,3 mikrogramu aktivního inkoustu, stojí přibližně jednu korunu a dával stabilní odezvu minimálně po dobu tří měsíců. Inkoust je navíc plně kompatibilní s běžně dostupnými inkoustovými materiálovými tiskárnami. To vytváří velký potenciál pro přípravu cenově dostupných, digitálně navržených senzorů, jejichž funkci lze přizpůsobovat atom po atomu,“ uvedl korespondující autor článku Michal Otyepka.Základem pro novou generaci atomárních inkoustů byla dusíkem dopovaná grafenová kyselina (NGA), kterou vědci z CATRIN vyvinuli před několika lety. Nyní ji postupně obohacovali různými jednotlivými atomy kovů včetně mědi, železa nebo manganu.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp 117w," sizes="100vw" width="1920" height="2560">„Ukázalo se, že elektrochemická odezva zásadně závisí na typu použitého atomu. Zatímco atomy mědi výrazně zesilují signál dopaminu, ostatní kovy jej naopak potlačují. Rozhodující&nbsp;tedy není jen samotná přítomnost izolovaných atomů kovu, ale také to, o jaký konkrétní kov se jedná. To je velmi důležitý poznatek pro další vývoj biosenzorů,“ objasnil první autor Martin-Alex Nalepa.Publikované výsledky představují novou třídu senzorických materiálů s velkým potenciálem v lékařské diagnostice. Vědci nabízí obecně využitelnou platformu pro vývoj grafenových inkoustů s jednotlivými atomy kovů a otevírají cestu ke škálovatelné, reprodukovatelné a materiálově úsporné výrobě pokročilých elektrochemických senzorů. „Jsme na začátku a fascinují nás nové možnosti, které se před námi otevírají. Vidíme, že změnou typu atomů můžeme řídit citlivost a selektivitu senzoru. Kromě dopaminu tak umíme velmi přesně stanovit například imunoglobuliny – protilátky, jejichž množství a typ mohou být důležitým ukazatelem autoimunitních nebo infekčních onemocnění,“ zdůraznil další z autorů článku Radek Zbořil.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp 117w," sizes="100vw" width="1920" height="2560">Elektrochemické biosenzory mohou nalézt uplatnění nejen v medicíně, ale také při kontrole kvality potravin, monitorování pitné vody nebo sledování znečištění životního prostředí. Jejich klíčovou součástí jsou funkcionalizované elektrody, pro jejichž výrobu se ukázaly jako velmi vhodné materiály právě na bázi grafenu. Základem úspěchu olomouckých vědců byla cílená příprava grafenového inkoustu s potřebnými vlastnostmi.Výzkum podpořil projekt TECHSCALE z operačního programu Jan Amos Komenský.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice: Projekt TECHSCALE (No.&nbsp;CZ.02.01.01/00/22_008/0004587) je financován z&nbsp;programu MŠMT&nbsp;OP&nbsp;JAK Špičkový výzkum, podpořeného z&nbsp;EFRR/ESF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg 245w," sizes="100vw" width="620" height="87"><blockquote><h4>Článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection</a></h4>Martin-Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendřišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal OtyepkaAdv. Sci., 2026, e76796<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/advs.76796">https://doi.org/10.1002/advs.76796</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>

Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice

Popularizace

Věda a výzkum

Video

Článek

Nejbližší akce

Škola hmotnostní spektrometrie je odborná vzdělávací akce pořádaná od roku 1986, která vedle zajímavých přednášek a kurzů nabízí i nespočet příležitostí k přátelským setkáním a diskusím.

Škola hmotnostní spektrometrie

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Noc vědců, akce oživující v jeden večer stovky vědeckých budov, do kterých se běžný smrtelník nedostane. Návštěvníci proplouvají laboratořemi, přednáškovými místnostmi, vybuchujícími experimenty a jdou do hloubky aktuálních témat. 

Noc vědců

Agilent Technologies

Shimadzu Corporation

Evosep Biosystems

Waters Corporation

It takes time, money, and resources to generate laboratory data, so any loss of data is a direct financial loss to your regulated company, as well as a major compliance risk. Laboratory data must be secured and available to support product quality decisions, both at the time of decision making and for the full duration of the mandated retention period.
A regulated company must ensure its data is retained through the retention period and maintains its integrity during that time. While external assistance can be sought with activities such as backup and restore, disaster recovery and business continuity planning, archiving, system administration and cybersecurity, the overall responsibility for the regulated data remains with the regulated company.
Key points of discussion will be:
<ol>
<li>Working with Servers</li>
<li>Having a Backup and Restore Plan</li>
<li>Developing a Disaster Recovery Plan</li>
<li>Have a Business Continuity Plan</li>
<li>Archiving Data</li>
<li>Cybersecurity Considerations</li>
<li>Updates to Software</li>
</ol>
Please join us for a live discussion as we explore this topic. As always, don’t forget to bring your Empower questions for this exclusive opportunity to ask our experts anything about Empower Software.
<blockquote>
Presenter: Neil Lander (Principal Product Manager, Waters Corporation)
</blockquote>
<blockquote>
Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.
</blockquote>
<blockquote>
Presenter: Fiona O&#39;Leary (Informatics Consultant, Waters Corporation)
</blockquote>
<blockquote>
Fiona is an experienced Empower Software and Data Integrity professional working within the EU Professional Services Team.
</blockquote>
<blockquote>
She has ~18 years of experience with Waters, beginning with Technical Support &amp; Empower Training, moving to Empower Consultancy and Workflow Optimization in more recent years. Her focus now is on building Data Integrity into the Lab workflow, Custom Field automation and Electronic Data Review / Reporting optimization.
</blockquote>
<blockquote>
Prior to joining Waters, Fiona spent some years in the GxP Pharmaceutical Manufacturing world, setting the scene for her current goal of helping organizations achieve their scientific and operational objectives efficiently and within compliance guidelines. She graduated from Dublin City University in 2001 with a BSc Hons. Analytical Science.
</blockquote>

Waters Corporation: A Guide to Ensuring Your Data Is Secure and Available from Creation Thru the Full Mandated Retention Period

A Guide to Ensuring Your Data Is Secure and Available from Creation Thru the Full Mandated Retention Period

As always, don’t forget to bring your Empower questions for this exclusive opportunity to ask our experts anything about Empower Software.

Ensuring Your Data Is Secure and Available

Biological samples represent formidable challenges in sample preparation that hold important consequences for LC analysis. Cleaner samples translate to more robust, reproducible LC analysis, with fewer repeat runs, and less equipment down time. The challenge is knowing which sample preparation technique to combine with both your sample and LC method.
In this discussion we will look at some common bio sample preparation techniques, from solvent exchanges to solid phase extractions. We will then discuss how to match the sample preparation technique to both your sample and the desired outcome of your chromatography.
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Presenter: Melissa Goodlad (Application Engineer, Agilent Technologies, Inc.)
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<blockquote>
Melissa Goodlad is an Application Engineer providing applications assistance and technical support for Agilent’s HPLC columns and consumables. Before joining Agilent, Melissa was completing her PhD in Physical Chemistry at UC Merced studying nanoparticle self-assemblies.
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Agilent Technologies: Sample Preparation for Improved LC Bio Separations

Sample Preparation for Improved LC Bio Separations

In this discussion we will look at some common bio sample preparation techniques, from solvent exchanges to solid phase extractions.

When it comes to LC analysis, a common question for users is, “Which LC column should I choose?” The column is the heart of the LC system, which plays a pivotal role in ensuring high-resolution separation. The fundamental knowledge of column selection can hence help you decide the optimal column for your specific application.
In this second series of Understanding LC Columns webinar, we will introduce the different mode of separation in liquid chromatography including reversed phase, normal phase and HILIC. We will discuss some of the common applications for each of these separation techniques. The difference in column chemistry and column specifications can significantly impact your separation. This webinar will also cover the different column chemistry and the considerations when selecting a column for the different applications.
Learning Objectives
<ul>
<li>Understand the different mode of separation and their application in liquid chromatography.</li>
<li>Understand the different column chemistry and their separation mechanisms.</li>
</ul>
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Presenter: Dr. Derrick Tan (Application Chemist (Consumables), Shimadzu (Asia Pacific) Pte Ltd)
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Dr. Derrick Tan obtained his PhD in chemistry from Nanyang Technological University, Singapore. He has more than 7 years of research experience in small molecules, nucleic acids, peptides and protein synthesis, separation and purification. He joined Shimadzu (Asia Pacific) Pte Ltd in 2021 as an Application Chemist (Consumables). At Shimadzu, he is responsible for the technical support and application of consumables in chromatography and spectroscopy. Products include LC and GC columns, UV/Vis cuvettes, sample vials and accessories.
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Shimadzu: Understanding LC Columns - Difference in Column Types and Phases

Understanding LC Columns - Difference in Column Types and Phases

We will introduce the different mode of separation in liquid chromatography including reversed phase, normal phase and HILIC.

Understanding LC Columns - Column Types and Phases

In UV-VIS-NIR spectroscopy, there is a wide range of instruments available that cover all measurements from routine to research.
We will discuss in this presentation some of the key performance differentiators between spectrometers as well as the impact that these have on measurement capabilities.
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Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
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Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
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Agilent Technologies: Picking the Right UV-Vis-NIR For Me: What Specs Do I Need?

Picking the Right UV-Vis-NIR For Me: What Specs Do I Need?

Key performance differentiators between UV-VIS-NIR spectrometers as well as the impact that these have on measurement capabilities.

How do I collect a UV-VIS Baseline? Why is my concentration curve non-linear? What amount of averaging do I need to do?
Join us in this webinar where we will discuss some of the most common questions for UV-VIS data collection.
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Presenter: Scott Melis, PhD (Application Scientist, gilent Technologies, Inc.)
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Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
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Agilent Technologies: Common UV-Vis Questions Answered

Common UV-Vis Questions Answered

Join us in this webinar where we will discuss some of the most common questions for UV-VIS data collection.

If you are new to our technology or just getting started this event is for you. We will introduce the basics of the Evosep One technology and include hot-from-the-lab data from our users. Nicolai Bache, Head of Applications at Evosep, will host the event, bringing you up to speed with the latest additions to the Evosep One technology.
The Evosep One is a plug-and-play standardized platform designed for robustness and high throughput. It has been designed specifically to address and eliminate the prevalent challenges associated with throughput and robustness of nano-flow LC-MS workflows while maintaining sufficient sensitivity and resolving power for clinical applications.
The Evosep One technology is centered around the Evotip and integrates sample preparation with LC-MS. The Evotip is essentially a disposable trap column in a pipette tip format with a small plug of C18 stationary phase at the bottom of the tip. The Evotips are used to desalt and clean up the samples prior to LC-MS analysis, however, the traditional subsequent steps of eluting, drying down, re-suspending the samples from tips are completely omitted and instead the tips are loaded directly into Evosep One for analysis.
The system uses four low-pressure syringe pumps in parallel to elute samples from the Evotip with a chromatographic gradient. The resulting gradient with the pre-separated sample is moved into a storage loop, that is then switched in-line with a single high-pressure pump and an analytical separation column for focusing. With this simplified workflow on pre-set gradients, the Evosep One offers a throughput from 30 to 300 samples per day.
<h5>1. A beginner’s guide to the Evosep One</h5>
<ul>
<li>Presenter: Nicolai Bache (Head of applications at Evosep)</li>
</ul>
The Evosep One technology is centered around the Evotip and integrates sample preparation with LC-MS. The Evotip is essentially a disposable trap column in a pipette tip format with a small plug of C18 stationary phase at the bottom of the tip. The Evotips are used to desalt and clean up the samples prior to LC-MS analysis, however, the traditional subsequent steps of eluting, drying down, re-suspending the samples from tips are completely omitted and instead the tips are loaded directly into Evosep One for analysis.
<h5>2. To be announced</h5>
<ul>
<li>Presenter: Anh Reynolds (Associate Scientist at BMS)</li>
</ul>
<h5>3. Clinical proteomics in the fast lane – Combination of robust LC, timsTOF based IMS-MS and GPU powered data processing</h5>
<ul>
<li>Presenter: Allan Stensballe (Industrial PHD at Aalborg University)</li>
</ul>
Mass spectrometrists who have been in the proteomics field long enough to be users of both early gel-free and gel-based strategies have learned to appreciate robust and fast analysis pipelines. As clinical proteomics projects now increasingly moves towards larger cohort studies and integration in multiOmics projects the stability and reproducibility of LC-MS to data analysis is imperative. In this talk I will highlight our experiences, project examples and thoughts on use of clinically optimized and standardized workflows.

A beginner’s guide to Evosep

The Evosep One is a plug-and-play standardized platform designed for robustness and high throughput.

At the analytical scale, liquid chromatography (LC) is widely used by scientists to separate, quantify, and characterize components in mixtures. At the preparative scale, LC is primarily used to purify samples for further downstream analysis. The adoption of preparative LC into a workflow, with larger columns and instrumentation, can appear to be a daunting task. However, by following some fundamental guidelines and a little practical advice, it can be quite simple.
<h5>Key learning objectives</h5>
<ul>
<li>Become familiar with the analytical to preparative chromatography workflow</li>
<li>Learn strategies to efficiently develop methods for purification success</li>
<li>Know how to avoid or recover from common mistakes</li>
<li>Understand how to think like a purification scientist</li>
</ul>
<h5>Who should attend?</h5>
<ul>
<li>Analytical and medicinal chemists who want to learn more about purification or preparative LC, or regarding scale-up from analytical to preparative LC</li>
<li>Lab managers supporting purification labs</li>
<li>Scientists who are curious about incorporating purification into their laboratory workflow</li>
</ul>
 
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Presenter: Scott Bollen (Business Development Manager EMEA, Agilent Technologies)
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Scott specializes in small molecule LC columns, ranging from HPLC to UHPLC. Scott has worked at Agilent for 17 years. He started as a technical support manager, and now supports new LC products in R&amp;D as well as the entirety of the existing small molecule LC column portfolio in business development.
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Agilent Technologies: Scale Up from Analytical to Prep with Agilent Prep LC Columns

Scale Up from Analytical to Prep with Agilent Prep LC Columns

Become familiar with the analytical to preparative chromatography workflow and learn strategies to efficiently develop methods for purification success.

From Analytical to Prep with Agilent Prep LC Columns

Join us on 18 &amp; 19 January for two half days of virtual presentations as we help you to navigate the every day challenges faced with the analysis of oligonucleotides. Presented by experts in the industry and the Agilent biopharma team, these short talks are designed to educate and provide insight from basic oligonucleotide assessment, through to the more advanced applications. Q&amp;A sessions will follow each presentation to give you the opportunity to engage with our speakers.
The agenda will cover these topics below and more!
<ul>
<li>Introduction to Oligonucleotide Therapeutics</li>
<li>Analytical &amp; Purification Methods</li>
<li>Workflows for Oligonucleotide CQAs</li>
<li>Practical Tips &amp; Tricks for Preparative HPLC</li>
<li>Analysis of mRNA 5&#39; Capping and Poly-A Tailing by High Resolution LC/MS</li>
</ul>
<h3>Agenda Day 1</h3>
<h5>10:00  Welcome to Agilent Oligo Insight Days</h5>
<h5>10:10 Introduction to Oligonucleotide Therapeutics</h5>
<h5>10:45 Oligonucleotide Analytical and Purification Methods</h5>
<h5>11:25 Workflows for Analysis of Oligonucleotide CQAs</h5>
<h5>12:05 Oligonucleotide Analysis - Tips &amp; Tricks: Putting it all into Practice</h5>

Agilent Technologies: Agilent Oligonucleotide Insight Days

Agilent Oligonucleotide Insight Days (Day 1)

Taking A Deeper Dive into Oligonucleotide Analysis

Join us on 18 &amp; 19 January for two half days of virtual presentations as we help you to navigate the every day challenges faced with the analysis of oligonucleotides. Presented by experts in the industry and the Agilent biopharma team, these short talks are designed to educate and provide insight from basic oligonucleotide assessment, through to the more advanced applications. Q&amp;A sessions will follow each presentation to give you the opportunity to engage with our speakers.
The agenda will cover these topics below and more!
<ul>
<li>Introduction to Oligonucleotide Therapeutics</li>
<li>Analytical &amp; Purification Methods</li>
<li>Workflows for Oligonucleotide CQAs</li>
<li>Practical Tips &amp; Tricks for Preparative HPLC</li>
<li>Analysis of mRNA 5&#39; Capping and Poly-A Tailing by High Resolution LC/MS</li>
</ul>
<h3>Agenda Day 1</h3>
<h5>10:00  Welcome to Agilent Oligo Insight Days</h5>
<h5>10:10  A Beginners Guide to LC/MS for the Analysis of Oligonucleotides</h5>
<h5>10:45 Analysis of mRNA 5&#39; Capping and Poly-A Tailing by High-Resolution LC/MS</h5>
<h5>11:20 Nucleic Acids Therapeutics Delivery by LNPs: Fundamentals and Characterizations</h5>
<h5>12:05 Oligonucleotide Purification - Tips and Tricks How to Scale Up!</h5>

Agilent Oligonucleotide Insight Days (Day 2)

It takes time, money, and resources to generate laboratory data, so any loss of data is a direct financial loss to your regulated company, as well as a major compliance risk. &nbsp;Laboratory data must be secured and available to support product quality decisions, both at the time of decision making and for the full duration of the mandated retention period.A regulated company must ensure its data is retained through the retention period and maintains its integrity during that time. &nbsp;While external assistance can be sought with activities such as backup and restore, disaster recovery and business continuity planning, archiving, system administration and cybersecurity, the overall responsibility for the regulated data remains with the regulated company.Key points of discussion will be:<ul><li>Working with Servers</li><li>Having a Backup and Restore Plan</li><li>Developing a Disaster Recovery Plan</li><li>Have a Business Continuity Plan</li><li>Archiving Data</li><li>Cybersecurity Considerations</li><li>Updates to Software</li></ul>Please join us for a live discussion as we explore this topic. &nbsp;As always, don’t forget to bring your Empower questions for this exclusive opportunity to ask our experts anything about Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.Presenter:&nbsp;Fiona O'Leary (Informatics Consultant, Waters Corporation)Fiona is an experienced Empower Software and Data Integrity professional working within the EU Professional Services Team.She has ~18 years of experience with Waters, beginning with Technical Support &amp; Empower Training, moving to Empower Consultancy and Workflow Optimization in more recent years. Her focus now is on building Data Integrity into the Lab workflow, Custom Field automation and Electronic Data Review / Reporting optimization. Prior to joining Waters, Fiona spent some years in the GxP Pharmaceutical Manufacturing world, setting the scene for her current goal of helping organizations achieve their scientific and operational objectives efficiently and within compliance guidelines. She graduated from Dublin City University in 2001 with a BSc Hons. Analytical Science.</blockquote>

Waters Corporation: Empower Tips Ask Me Anything About Durable Data: A Guide to Ensuring Your Data Is Secure and Available from Creation Thru the Full Mandated Retention Period

Empower Tips Ask Me Anything About Durable Data: A Guide to Ensuring Your Data Is Secure and Available from Creation Thru the Full Mandated Retention Period

Protecting lab data is critical for compliance and financial health. Learn key strategies for secure retention, recovery, and cybersecurity in regulated labs.