Noc vědy 2026 - Komunikace

Třetí den <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/all/events/930">27. Školy hmotnostní spektrometrie</a>, středa 23. září 2026, se dopoledne nesl ve znamení omických přístupů a metod, které posouvají možnosti běžné LC-MS analýzy. Zdeněk Spáčil otevřel program přehledem akvizičních strategií od full scanu a MS/MS přes DDA, DIA/SWATH a PRM/MRM až po HRMS, na který Jaroslava Friedecká navázala tématem společného vyhodnocování metabolomických, proteomických a lipidomických dat. Sekce „Za hranicemi rutinní MS“ pak ukázala další směry současné hmotnostní spektrometrie: Pavel Hrouzek představil využití stabilních izotopů při studiu metabolických drah, Robert Jirásko se zaměřil na iontovou mobilitu v LC/MS při analýze malých molekul a dopolední odborný blok uzavřela přednáška společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> věnovaná ionizační technologii <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/lcms/library?mainauthorItems=53&amp;search=SICRIT">SICRIT®</a>.Po intenzivním odborném programu přišlo na řadu tradiční kulturně-poznávací odpoledne. Účastníci si mohli vybrat mezi návštěvou Vyššího Brodu a tamního kláštera, výletem do Českého Krumlova spojeným s prohlídkou grafitového dolu, pěší túrou na Vítkův kámen nebo individuálním programem, jehož součástí byl také turnaj ve stolním fotbálku. Večer pak třetí konferenční den pokračoval společenským programem společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>, tentokrát v podobě Silent disco a tanečního večera.<h3>Program</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/program_Skola_MS_2026_final_8c8cf90056.pdf">Finální program 27. Školy MS je ke stažení zde</a></blockquote><h4>Středa, 23. 9. 2026</h4><h5>SEKCE VII. Od MS k omikám</h5><h5>08:30 – 09:15 Strategie akvizice v LC-MS: full scan vs. MS/MS, DDA vs. DIA (SWATH), PRM/MRM, HRMS&nbsp;</h5><ul><li>Zdeněk Spáčil&nbsp;</li></ul><h5>09:15 – 10:00 Kombinovaná analýza metabolomických, proteomických a lipidomických dat&nbsp;</h5><ul><li>Jaroslava Friedecká&nbsp;</li></ul><h5>10:00 – 10:30 Přestávka na kávu&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Waters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Phenomenex" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>SEKCE VIII. Za hranicemi rutinní MS&nbsp;</h5><h5>10:30 – 11:00 Od izotopové obálky k metabolickým drahám: využití stabilních izotopů při studiu primárního metabolismu a biosyntézy specializovaných metabolitů&nbsp;</h5><ul><li>Pavel Hrouzek&nbsp;</li></ul><h5>11:00 – 11:30 Současné techniky iontové mobility v LC/MS a jejich využití při analýze malých molekul&nbsp;</h5><ul><li>Robert Jirásko&nbsp;</li></ul><h5>11:30 – 12:00 <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>: SICRIT®: Nová dimenze v MS ionizaci&nbsp;</h5><ul><li>Jan Buček</li></ul><h5>12:00 – 13:30 Oběd&nbsp;</h5><h5>KULTURNĚ POZNÁVACÍ ODPOLEDNE&nbsp;</h5><ul><li>A Vyšší Brod – procházka městem, prohlídka kláštera&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg 233w," sizes="100vw" width="1600" height="1072"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg 208w," sizes="100vw" width="1600" height="1201"><ul><li>B Český Krumlov – prohlídka města, grafitový důl&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Návštěva grafitového dolu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg 207w," sizes="100vw" width="1600" height="1210"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Prohlídka města" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg 208w," sizes="100vw" width="1600" height="1200"><ul><li>C Vítkův kámen – pěší túra&nbsp;</li><li>D Individuální program&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>19:00 – 20:30 Večeře&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Večerní program" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>20:30 – ??? Společenský večer firmy <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> - Silent disco</h5><ul><li>Taneční večer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Společenský večer firmy Shimadzu - Silent disco" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg 245w," sizes="100vw" width="1600" height="900">

27. Škola MS 2026 - den 3

Nový grafenový inkoust pro výrobu levných a citlivých tištěných senzorů vyvinuli výzkumníci z CATRIN Univerzity Palackého ve spolupráci s kolegy z VŠB-Technické univerzity Ostrava a Univerzity Karlovy. Při přípravě inkoustu poprvé využili metodu atomárního inženýrství a díky navázaným atomům mědi jsou schopni detekovat velmi citlivě dopamin – neurotransmiter, který umožňuje přenos signálů mezi nervovými buňkami. Přístup <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">představený v časopise Advanced Science</a> má velké šance uplatnit se v lékařské diagnostice.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp 117w," sizes="100vw" width="1920" height="2560">Atomární inženýrství (single-atom engineering) umožňuje řídit chemickou reaktivitu materiálů na úrovni jednotlivých atomů. Jeho širšímu uplatnění v lékařské diagnostice však dosud bránil nedostatek atomárně upravených materiálů i absence na nich založených tisknutelných inkoustů.&nbsp;Nyní se vědcům podařilo vyvinout novou třídu atomárně dopovaných grafenových materiálů a také inkoust pro přípravu citlivých tištěných senzorů. Sázka na měď se vyplatila při detekci dopaminu, jehož sledování je důležité pro biomedicínský výzkum a vývoj pokročilých diagnostických technologií některých onemocnění včetně Alzheimerovy choroby.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp 117w," sizes="100vw" width="1920" height="2560">„Vyvinutý NGA-Cu inkoust umožňuje výrobu plně inkoustově tištěných udržitelných papírových elektrod s velmi nízkými náklady. Samotný senzor vyžaduje pouze 1,3 mikrogramu aktivního inkoustu, stojí přibližně jednu korunu a dával stabilní odezvu minimálně po dobu tří měsíců. Inkoust je navíc plně kompatibilní s běžně dostupnými inkoustovými materiálovými tiskárnami. To vytváří velký potenciál pro přípravu cenově dostupných, digitálně navržených senzorů, jejichž funkci lze přizpůsobovat atom po atomu,“ uvedl korespondující autor článku Michal Otyepka.Základem pro novou generaci atomárních inkoustů byla dusíkem dopovaná grafenová kyselina (NGA), kterou vědci z CATRIN vyvinuli před několika lety. Nyní ji postupně obohacovali různými jednotlivými atomy kovů včetně mědi, železa nebo manganu.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp 117w," sizes="100vw" width="1920" height="2560">„Ukázalo se, že elektrochemická odezva zásadně závisí na typu použitého atomu. Zatímco atomy mědi výrazně zesilují signál dopaminu, ostatní kovy jej naopak potlačují. Rozhodující&nbsp;tedy není jen samotná přítomnost izolovaných atomů kovu, ale také to, o jaký konkrétní kov se jedná. To je velmi důležitý poznatek pro další vývoj biosenzorů,“ objasnil první autor Martin-Alex Nalepa.Publikované výsledky představují novou třídu senzorických materiálů s velkým potenciálem v lékařské diagnostice. Vědci nabízí obecně využitelnou platformu pro vývoj grafenových inkoustů s jednotlivými atomy kovů a otevírají cestu ke škálovatelné, reprodukovatelné a materiálově úsporné výrobě pokročilých elektrochemických senzorů. „Jsme na začátku a fascinují nás nové možnosti, které se před námi otevírají. Vidíme, že změnou typu atomů můžeme řídit citlivost a selektivitu senzoru. Kromě dopaminu tak umíme velmi přesně stanovit například imunoglobuliny – protilátky, jejichž množství a typ mohou být důležitým ukazatelem autoimunitních nebo infekčních onemocnění,“ zdůraznil další z autorů článku Radek Zbořil.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp 117w," sizes="100vw" width="1920" height="2560">Elektrochemické biosenzory mohou nalézt uplatnění nejen v medicíně, ale také při kontrole kvality potravin, monitorování pitné vody nebo sledování znečištění životního prostředí. Jejich klíčovou součástí jsou funkcionalizované elektrody, pro jejichž výrobu se ukázaly jako velmi vhodné materiály právě na bázi grafenu. Základem úspěchu olomouckých vědců byla cílená příprava grafenového inkoustu s potřebnými vlastnostmi.Výzkum podpořil projekt TECHSCALE z operačního programu Jan Amos Komenský.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice: Projekt TECHSCALE (No.&nbsp;CZ.02.01.01/00/22_008/0004587) je financován z&nbsp;programu MŠMT&nbsp;OP&nbsp;JAK Špičkový výzkum, podpořeného z&nbsp;EFRR/ESF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg 245w," sizes="100vw" width="620" height="87"><blockquote><h4>Článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection</a></h4>Martin-Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendřišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal OtyepkaAdv. Sci., 2026, e76796<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/advs.76796">https://doi.org/10.1002/advs.76796</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>

Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice

Popularizace

Věda a výzkum

Video

Článek

Nejbližší akce

Škola hmotnostní spektrometrie je odborná vzdělávací akce pořádaná od roku 1986, která vedle zajímavých přednášek a kurzů nabízí i nespočet příležitostí k přátelským setkáním a diskusím.

Škola hmotnostní spektrometrie

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Noc vědců, akce oživující v jeden večer stovky vědeckých budov, do kterých se běžný smrtelník nedostane. Návštěvníci proplouvají laboratořemi, přednáškovými místnostmi, vybuchujícími experimenty a jdou do hloubky aktuálních témat. 

Noc vědců

Agilent Technologies

Bruker

GERSTEL

SelectScience

C&EN

Evosep Biosystems

In recent years, there has been a growing movement to promote alternative methods to animal testing and the EU and a few other countries have even moved to ban the import and sale of cosmetics that have been tested on animals. The Amino acid Derivative Reactivity Assay (ADRA) Method developed by Fujifilm, is an innovative alternative test method for skin sensitization without the use of animals and it was adopted by the OECD in 2022 as a reliable test method.
In this webinar, we will present the technical background of the ADRA method, the use of reagent kits to perform ADRA testing, and our solutions for ADRA analysis that deliver both enhanced selectivity and high-speed testing. Register for this webinar and learn more about how the ADRA method will help you better test the safety of cosmetics and pharmaceuticals. 
<h5>Key Learning Objectives:</h5>
<ul>
<li>Outline of the OECD TG442C (ADRA: Amino acid Derivative Reactivity Assay) </li>
<li>Overview of ADRA kits and related products </li>
<li>How to conduct ADRA testing using HPLC</li>
</ul>
<h5>Who Should Attend:</h5>
<ul>
<li>R&amp;D and Manufacturer of Cosmetics </li>
<li>Companies considering Alternative Methods to Animal Testing </li>
<li>Industries interested in Alternative Methods to Animal Testing</li>
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<blockquote>
Presenter: Toshihiko Kasahara, Ph.D. (Safety Eval. Center, ESG Div., Senior Expert, Fujifilm Corporation)
</blockquote>
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Presenter: Suguru Kitagawa (International Sales, EU Region, Fujifilm Wako Pure Chemical Corporation)
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Presenter: Ayako Nomura (Analytical Instr. Div., Application Specialist, Shimadzu Corporation)
</blockquote>
<blockquote>
Presenter: Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)
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Shimadzu: The Newest Alternative to Animal Testing for Skin Sensitization

The Newest Alternative to Animal Testing for Skin Sensitization

In this webinar, we will present the technical background of the ADRA method and how to conduct ADRA testing using HPLC.

The Alternative to Animal Testing for Skin Sensitization

Join us in this webinar to discuss on basics of GPC technology and respective details of instruments, separations, and parameters in GPC analysis. Along with respective principles and uses for various types of large/polymer samples.
In this webinar, we will discuss:
<ul>
<li>Introduction to GPC</li>
<li>Need of fast GPC and its advantages</li>
<li>Considerations for fast GPC analysis and optimization options</li>
<li>Optimization of various method parameters for good resolution, peak shape and response</li>
<li>Column selection criteria for better results with relevant applications</li>
<li>Agilent columns options for fast GPC analysis</li>
</ul>
By attending this webinar you will learn: How to systematically convert traditional GPC methods to fast GPC, optimize your method parameters for fast GPC analysis and increase lab productivity with proper column selection.
*Attend all 3 sessions and get a digital certificate from Agilent
<blockquote>
Presenter: Dr. Ramaprasad Ganni (Technical Support Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Ramaprasad Ganni has 21 years of experience in the field of Chromatography and Column chemistries. Working with Agilent technologies India, since 2008 in Chemistries and Supplies division. Previously Worked for Elsevier GmbH, and Millipore India Pvt, Ltd. Responsible for Workflow solutions development, providing technical support, and trainings. Experienced in Sample prep, HPLC, GC, Mass spec and GPC Chromatography technologies.
</blockquote>

Agilent Technologies: Pace Up with Fast GPC Analysis

Pace Up with Fast GPC Analysis

How to convert traditional GPC methods to fast GPC, optimize method parameters for fast GPC and increase lab productivity with proper column selection.

Join this webinar to learn how to simplify, speed-up, and standardize your proteomics sample preparation for LC-MS.
The PreOmics team will introduce the PreOmics easy-to-use iST technology. This fast 3-step workflow is designed to be a great support for both those new to proteomics and experts alike. The all-in-one iST kits are compatible with a variety of starting materials, including mammalian and plant samples, different types of tissue and cells, as well as various biological fluids in label-free and chemical labelling applications.The protocols promise an incredibly fast processing time (&lt;2.5 hours) and are easily applicable without compromising sample quality or proteomic depth. Furthermore, iST can be fully automated to further increase standardization, reproducibility, and throughput.
The speakers will also introduce PreON, a fully automated sample preparation platform, as well as different levels of automation for established liquid handling platforms. The varying applications for the iST technology ranging from global proteomics to pre-clinical studies will also be discussed.
<h5>Key learning objectives</h5>
<ul>
<li>Discover best practices for proteomics sample preparation with solutions for new users and proteomics experts alike</li>
<li>Learn more about fast, easy, and reliable sample preparation protocols for LC-MS-based proteomics</li>
<li>Explore automation, standardization, and upscaling of proteomics sample preparation</li>
<li>Learn more about the applications of iST sample preparation kits and solutions in global proteomics as well as pre-clinical research</li>
</ul>
<h5>Who should attend?</h5>
<ul>
<li>Users working with proteomics sample preparation for LC-MS:</li>
<li>Researchers, scientists, principal investigators, group leaders and department heads, lab assistants from biotech/pharma industry, CROs, university hospitals as well as academia</li>
<li>Biomedical and clinical scientists in translational and pre-clinical research</li>
<li>Application scientists and technical support</li>
<li>Distributors of sample preparation systems for LC-MS</li>
<li>Scientists looking for a straightforward approach to start with proteomics</li>
</ul>
<blockquote>
Presenter: Dr. Ingrid Albrecht-Walz (PreOmics GmbH)
</blockquote>
<blockquote>
Dr. Ingrid Albrecht-Walz joined PreOmics in 2022 as Product Manager for Kits &amp; Reagents. She received her Ph.D. in Biology from the University of Munich, Germany, working on the interaction of different viruses. For the past 10 years, Dr. Albrecht-Walz has worked in the field of in vitro diagnostics of infectious diseases. Since proteomics is a highly promising tool for preclinical and diagnostic applications, Dr. Albrecht-Walz decided in 2022 to follow this opportunity at PreOmics.
</blockquote>
<blockquote>
Presenter: Dr. Vincenzo Romaniello (PreOmics GmbH)
</blockquote>
<blockquote>
Dr. Vincenzo Romaniello joined PreOmics in 2021 as Product Manager for Automation Systems. He received his Ph.D. in molecular physiology from the University of Göttingen, Germany. During the past 5 years, Dr. Romaniello has worked in both technical and application support roles for automated sample preparation workflows with major biotech and human diagnostics scientific suppliers. As a result, he has experience in PreOmics automation solutions, and Tecan and Eppendorf systems.
</blockquote>
<blockquote>
Presenter: Dr. Zuzana Demianova (PreOmics GmbH)
</blockquote>
<blockquote>
Dr. Demianova joined PreOmics in 2021 as a Market Development Manager BioPharma and scientific advisor. Assessing proceedings and challenges in the pharma and biopharma field Dr. Demianova introduces PreOmics’ solutions in customer workflows to enable scientific discovery. She thereby partakes also in the development and market introduction of new products as well as optimization and application of established solutions. Prior to PreOmics, Dr. Demianova was application support specialist at Sciex, concentrating on customer support and training. Later on, she was promoted to a global leader in proteomics, which finally led up to her new role as a biopharma application scientist with a focus on “-omics” and biopharma applications using CE and LC-MS technologies.
</blockquote>
<blockquote>
Presenter: Blake Forman (SelectScience)
</blockquote>
<blockquote>
Blake studied chemistry at the University of Surrey, UK, and further went on to study a master’s in chemistry at the University of Southampton, UK. Blake has previously worked in the Medicines and Healthcare Products Regulatory Agency (MHRA) lab at LGC and as a technical sales specialist for Waters. As a member of the Editorial team, he now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Next generation solutions for proteomics sample preparation

Next generation solutions for proteomics sample preparation

Join this webinar to learn how to simplify, speed-up, and standardize your proteomics sample preparation for LC-MS.

Dear user and other PaSER interested customers,
You are hereby invited to our 2nd Virtual PaSER Workshop. A lot of new possibilities has been introduced since last time – including, but not limited to PaSER Novor for de novo sequencing of dda-PASEF® data on the PaSER Box as well as TIMS DIA-NN 2.0 -which will be demonstrated during this Workshop. Data virtualization has been a requested feature – and this is now possible with Mass Dynamics for PaSER. Not limited to above – stay tuned for even more approaching features, we will discuss as well.
<h3>The tentative agenda looks like this:</h3>
<h5>1:00 – 1:15 pm: Introduction</h5>
<ul>
<li>Willy Bjørklund</li>
</ul>
<h5>1:15 – 1: 35pm: New Applications on the timsTOF Platform</h5>
<ul>
<li>Lars Kristensen (Field Application Specialist)</li>
</ul>
<h5>1:35 – 1:55 pm: PaSER as a bioinformatic platform - what’s new and what’s coming</h5>
<ul>
<li>Jonathan Krieger (Software R&amp;D Department)</li>
</ul>
<h5>5 minute break</h5>
<h5>2:00 – 2:20 pm: Live Demo/workshop of PaSER</h5>
<ul>
<li>Tharan Srikumar (Software R&amp;D Department)</li>
</ul>
<h5>2:20 – 2:50 pm: Mass Dynamics</h5>
<ul>
<li>Mark Condina and Giuseppe Infusini</li>
</ul>
<h5>2:50 – 3:10 pm: Questions and discussions</h5>
<h5>3:10 – 3:15 pm: Conclusion</h5>
<ul>
<li>Willy Bjørklund</li>
</ul>
We aim for a lively interaction so take the timing as an indication. Please feel free to share with colleagues or others you think could benefit from attending this workshop. Looking forward to “meet”

Bruker Virtual PaSER Workshop

Dear user and other PaSER interested customers, You are hereby invited to our 2nd Virtual PaSER Workshop. 

Get ready for Nitrosamines - The LC/MS Edge, a series of virtual connect that explores the latest updates, insights, and technical knowledge on nitrosamines in India.
Join us for the first session, focused on the growing concern of nitrosamines in the Indian pharmaceutical industry. Learn about the perspective of Indian Pharmacopoeia on regulation, evolving market landscape, growth opportunities and the role of LC-MS/MS in nitrosamine assessment studies. Experts will discuss the perspectives of evolving regulations and how companies can adapt these solutions, followed by a Q&amp;A discussion. Nitrosamines pose a significant risk to public health, making it crucial for companies to be aware of the latest regulations and market trends. Stay ahead of the curve and ensure compliance with latest regulatory requirements. Don&#39;t miss out on this valuable opportunity. 
Why should you attend?
<ul>
<li>Gain insights into the perspective of Indian Pharmacopoeia on assessment of nitrosamines.</li>
<li>Understand the current market landscape and growth opportunities.</li>
<li>Learn about compliance requirements and how to navigate them.</li>
<li>Stay up-to-date on the latest trends and updates related to nitrosamines in India.</li>
<li>Improve your professional development &amp; scientific understanding by enhancing your knowledge and skills related to nitrosamines assessment workflows and LC/MS.</li>
</ul>
<blockquote>
Presenter: Mr. Arvind Kumar Sharma (Scientific Assistant, Indian Pharmacopoeia Commission, Ministry of Health &amp; Family Welfare - Government of India)
</blockquote>
<blockquote>
With six years of experience as a Scientific Assistant at Indian Pharmacopoeia Commission, he has played a key role in the current development of Indian Pharmacopoeia Reference Substances (IPRS) and Impurity Reference Substances. He has been engaged in the preparation and updating of draft monographs for publishing in Indian Pharmacopoeia (IP). Additionally, he has played a major role in the development of the latest edition of the National Formulary of India 2021 and has been involved in work related to the Pharmacovigilance Programme of India (PvPI). He holds a a M. Pharmacy in Pharmacology from Sinhgad Institute of Pharmaceutical Sciences, Pune and a B. Pharmacy from the College of Pharmacy, IPS Academy Indore. He has authored several articles published in international journals and organized and represented IPC at various national and international conferences and workshops. He has also participated in joint inspections for registration of manufacturing units and testing laboratories.
</blockquote>
<blockquote>
Presenter: Dr Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies India Pvt Ltd)
</blockquote>
<blockquote>
Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.
</blockquote>

Agilent Technologies: Nitrosamines - The LC/MS Edge 1st Edition: Indian Pharmaceutical Industry Perspective & Evolving Regulatory Landscape

Nitrosamines - The LC/MS Edge 1st Edition: Indian Pharmaceutical Industry Perspective & Evolving Regulatory Landscape

Join us for the first session, focused on the growing concern of nitrosamines in the Indian pharmaceutical industry.

Nitrosamines - The LC/MS Edge 1st Edition

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
An easy to follow guide detailing how to set MS scan parameters for an LCMS experiment will be presented. Scan speeds for reproducible quantitation, chromatographic resolution, retention time definition, proper threshold adjustment for optimum datafile size, and how this can result in faster processing times will all be discussed.
<blockquote>
Presenter: Rebecca Glaskin, Ph.D. (LC/MS Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rebecca Glaskin is an LC/MS Application Scientist at Agilent with a focus on BioPharma applications supporting the LC-Q/TOF and IM-QTOF platforms. Prior to joining Agilent, Rebecca received her Ph.D. in analytical chemistry from Indiana University in the lab of Professor David Clemmer. While there she designed and constructed home-built instruments, pushing the limits of the mobility resolution that can be obtained with a circular drift tube for the separation of biomolecules (peptides, proteins, carbohydrates, and metabolites). While there, she also studied hydrogen/deuterium exchange of proteins in the gas-phase as a function of time and pressure. Rebecca then went to Boston University as a Postdoctoral Associate in the lab of Professor Catherine Costello to develop a database containing collision cross section values for glycans, peptides, and glycopeptides utilizing Agilent Technologies 6560 IM-QTOF. This database can be used to determine how the collision cross section is altered with the addition of individual saccharide units. The trendlines obtained from this database will be used to predict collision cross sections for glycopeptides based on the conformation and structure of the specific glycoform.
</blockquote>
<blockquote>
Presenter: Jim Lau, PhD (HRAMS LC/MS Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Jim Lau received his Ph.D. From the University of Colorado. There he worked in the laboratories of Peter Albersheim and Robert Shapiro. This work involved the structure elucidation of plant natural products and, in particular, elucidating the structures of oligosaccharides derived from plant cell wall polysaccharides. This work was done in the early days of LCMS and made use of DLI-LCMS and (at the time) recently invented Thermospray-LCMS.
</blockquote>
<blockquote>
After the completion of his Ph.D., Jim joined Hewlett-Packard to work on LCMS ionization techniques with Paul Goodley during the early days of Electrospray-LCMS. He then moved to work on field applications and collaborations with Hewlett-Packard’s LCMS customers. More than 30 years later, Jim continues to work with Agilent’s customers in High Resolution Accurate Mass applications of LCMS. While involved in many areas of HRAMS LCMS, his recent work has focused on the area of Screening/Qual&amp;Quant of small molecules and on the high throughput confirmation of oligonucleotide synthesis.
</blockquote>

Agilent Technologies: How to set MS Scan Parameters for your LCMS Experiment

How to set MS Scan Parameters for your LCMS Experiment

An easy to follow guide detailing how to set MS scan parameters for an LCMS experiment will be presented.

Targeted workflows are particularly interesting for identifying established biomarkers in various applications. The focus on these workflows, coupled with technological advancements, is continually expanding the boundaries of high-throughput targeted analysis.
<h3>Next Generation of absolute protein Quantitation in Biological Matrixes; higher multiplexicity while faster, robust and sensitive</h3>
<ul>
<li>Presenter: Dr. Christoph Borchers (Mcgill university)</li>
</ul>
The accurate and rapid determination of protein concentrations using multiplexed multiple reaction monitoring (MRM) with isotope-labeled internal standards has the potential to revolutionize biochemistry and medical sciences. The combination of an Evosep One LC with an Agilent QQQ6495C allows a several-fold reduction of analysis time while maintaining high multiplexicity. As an example, we show the use of a multi-protein method for the absolute quantitation of 270 proteins, combined with metabolomics and Artificial Intelligence (AI), to analyze the plasma of a COVID cohort for prediction of survival. Moreover, optimization of the Evosep/6495C combination allowed adaptation of the 270-protein MRM method to a 24-minute gradient, thus doubling the throughput compared to before.
<h3>Development of a LC-MS/MS Method for Measurement of Fusion Sarcoma Proteins in Plasma</h3>
<ul>
<li>Presenter: Phd. AnThony Maus (Clinical Mass Spec. Development Laboratory, Mayo Clinic)</li>
</ul>
Sarcoma is general term for a group of over 70 cancers that are classified using genomic techniques to identify characteristic gene fusions in tumor tissues. However, this technique requires relatively invasive biopsies and is not conducive to monitoring disease progression or response to treatment. Measurements of fusion protein biomarkers in plasma would overcome these limitations. We sought to develop an LC-MS/MS method capable of performing these measurements by conducting discovery experiments on cell lines with an EvoSep coupled to an Exploris 480 mass spectrometer. Using these data, we developed a targeted method and performed measurements in plasma samples.

Targeted Workflows

Targeted workflows are particularly interesting for identifying established biomarkers in various applications.

Targeted LC/MS Workflows

Webinar in collaboration with the Polish Society of Metabolomics.
<h3>14:00 - 14:20 Benefits of Trapped Ion Mobility Spectrometry (TIMS) for Metabolomics and Lipidomics</h3>
<ul>
<li>Presenter: Dr. Stefanie Wernisch ( Business Development Manager Metabolomics/Multiomics, Bruker Daltonics Bremen, Germany)</li>
</ul>
After revolutionizing the area of proteomics, trapped ion mobility spectrometry (TIMS) is now conquering the fields of metabolomics and lipidomics. Bruker&#39;s unique timsTOF technology addresses the complexity of biological samples by adding an orthogonal dimension of separation before mass spectrometric analysis, thus reducing the complexity of MS/MS data and improving annotation confidence for untargeted analysis. The ability to determine Collisional Cross Sections (CCS) can further aid identification and outlier detection in lipidomics studies.
<h3>14:20 - 14:40 SpatialOMx® for in-depth 4D-Lipidomics™</h3>
<ul>
<li>Presenter: Dr. Janina Oetjen (Application Specialist MALDI Imaging, Bruker Daltonics Bremen, Germany)</li>
</ul>
The combined possibilities of ESI and MALDI in one instrument enables powerful SpatialOMx® applications. In short, ion mobility-based annotation can connect confident LC-TIMS-MS/MS identification with meaningful spatial information from MALDI Imaging, specifically in the field of lipidomics. Further, segmentation results based on lipid imaging can define specific regions of interest for subsequent, in-depth analysis. Thus, the information content of MALDI Imaging can be enhanced with SpatialOMx® workflows on the timsTOF fleX platform.
<h3>14:40 - 15:00 Application Round-up: 4D-Metabolomics™ and 4D-Lipidomics™</h3>
<ul>
<li>Presenter: Dr. Matthias Szesny (Application Scientist Metabolomics, Bruker Daltonics Bremen, Germany)</li>
</ul>
We will highlight the capabilities of the timsTOF platform and introduce new applications, method developments, and software solutions in the field of metabolomics and lipidomics. Those help scientists gain a faster and deeper understanding of diverse research areas such as health and disease as well as agriculture.

Bruker: Expanding the Horizons of 4D-Metabolomics and 4D-Lipidomics

Expanding the Horizons of 4D-Metabolomics and 4D-Lipidomics

Benefits of TIMS for Metabolomics and Lipidomics. SpatialOMx for in-depth 4D-Lipidomics, Application Round-up: 4D-Metabolomics and 4D-Lipidomics.

Learn how to automate your SPE procedures with the LCTech FREESTYLE™ system for various sample types.
Presenter: Fred Foster (Applications Scientist)

GERSTEL: Automation of Solid Phase Extraction Procedures using a Novel Robotic Automation Platform

Automation of Solid Phase Extraction Procedures using a Novel Robotic Automation Platform

Learn how to automate your SPE procedures with the LCTech FREESTYLE™ system for various sample types.

Automation of Solid Phase Extraction - Automation Platform

The solubility of orally administered drugs is highly influenced by the composition of the intestinal fluids, the presence of fatty acids and cholesterol, and the pH. All these factors can be affected by the individual’s diet (food effect). Typical biorelevant studies, however, fail to capture food effects as the experiments are commonly performed on fixed simulated intestinal fluid (SIF) compositions. Consequently, accurate prediction of the food effect observed in clinical studies is hindered due to lack of reliable data for the model.Here, we propose a high-throughput automated workflow for the study of API solubility in complex, ad hoc biorelevant media, and the implementation of the data obtained in vitro into a Physiologically Based Biopharmaceutic Model (PBBM) used to predict the food effect on a BCS IV zwitterionic drug. The automated workflow led to considerable time and material savings, while the model accurately predicted the results of the food effect.Key Learning Objectives:<ul><li>Determination of food effect, through use of complex biorelevant media, to describe and predict clinical data</li><li>Automated preparation of ad hoc complex biorelevant media</li><li>Automated in vitro biorelevant solubility screen of an API</li><li>Integration of in vitro solubility and permeability into a Physiologically</li><li>Based Biopharmaceutic Model (PBBM)</li></ul>Who Should Attend:<ul><li>Scientist, Sr. Scientist, Development Chemist, Formulation Chemist, Process Chemist, (Directors of preceding), Research Fellow, Professor</li><li>Product Development Scientists, Biochemist</li></ul><blockquote>Presenter:&nbsp;Paola Ferrini (Investigator, High-Throughput Automation Team, GSK)Presenter: Konstantinos Stamatopoulos (Biopharmaceutics Investigator, GSK)Presenter: Catherine Dold (Health &amp; Environment Writer, C&amp;EN Media Group)</blockquote>

C&EN: Automated In Vitro Sample Preparation for PBBM to Predict Food Effect on Oral Drugs

Automated In Vitro Sample Preparation for PBBM to Predict Food Effect on Oral Drugs

We propose a high-throughput automated workflow for the study of API solubility in complex, ad hoc biorelevant media.