Noc vědy 2026 - Komunikace

Třetí den <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/all/events/930">27. Školy hmotnostní spektrometrie</a>, středa 23. září 2026, se dopoledne nesl ve znamení omických přístupů a metod, které posouvají možnosti běžné LC-MS analýzy. Zdeněk Spáčil otevřel program přehledem akvizičních strategií od full scanu a MS/MS přes DDA, DIA/SWATH a PRM/MRM až po HRMS, na který Jaroslava Friedecká navázala tématem společného vyhodnocování metabolomických, proteomických a lipidomických dat. Sekce „Za hranicemi rutinní MS“ pak ukázala další směry současné hmotnostní spektrometrie: Pavel Hrouzek představil využití stabilních izotopů při studiu metabolických drah, Robert Jirásko se zaměřil na iontovou mobilitu v LC/MS při analýze malých molekul a dopolední odborný blok uzavřela přednáška společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> věnovaná ionizační technologii <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/lcms/library?mainauthorItems=53&amp;search=SICRIT">SICRIT®</a>.Po intenzivním odborném programu přišlo na řadu tradiční kulturně-poznávací odpoledne. Účastníci si mohli vybrat mezi návštěvou Vyššího Brodu a tamního kláštera, výletem do Českého Krumlova spojeným s prohlídkou grafitového dolu, pěší túrou na Vítkův kámen nebo individuálním programem, jehož součástí byl také turnaj ve stolním fotbálku. Večer pak třetí konferenční den pokračoval společenským programem společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>, tentokrát v podobě Silent disco a tanečního večera.<h3>Program</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/program_Skola_MS_2026_final_8c8cf90056.pdf">Finální program 27. Školy MS je ke stažení zde</a></blockquote><h4>Středa, 23. 9. 2026</h4><h5>SEKCE VII. Od MS k omikám</h5><h5>08:30 – 09:15 Strategie akvizice v LC-MS: full scan vs. MS/MS, DDA vs. DIA (SWATH), PRM/MRM, HRMS&nbsp;</h5><ul><li>Zdeněk Spáčil&nbsp;</li></ul><h5>09:15 – 10:00 Kombinovaná analýza metabolomických, proteomických a lipidomických dat&nbsp;</h5><ul><li>Jaroslava Friedecká&nbsp;</li></ul><h5>10:00 – 10:30 Přestávka na kávu&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Waters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Phenomenex" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>SEKCE VIII. Za hranicemi rutinní MS&nbsp;</h5><h5>10:30 – 11:00 Od izotopové obálky k metabolickým drahám: využití stabilních izotopů při studiu primárního metabolismu a biosyntézy specializovaných metabolitů&nbsp;</h5><ul><li>Pavel Hrouzek&nbsp;</li></ul><h5>11:00 – 11:30 Současné techniky iontové mobility v LC/MS a jejich využití při analýze malých molekul&nbsp;</h5><ul><li>Robert Jirásko&nbsp;</li></ul><h5>11:30 – 12:00 <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>: SICRIT®: Nová dimenze v MS ionizaci&nbsp;</h5><ul><li>Jan Buček</li></ul><h5>12:00 – 13:30 Oběd&nbsp;</h5><h5>KULTURNĚ POZNÁVACÍ ODPOLEDNE&nbsp;</h5><ul><li>A Vyšší Brod – procházka městem, prohlídka kláštera&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg 233w," sizes="100vw" width="1600" height="1072"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg 208w," sizes="100vw" width="1600" height="1201"><ul><li>B Český Krumlov – prohlídka města, grafitový důl&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Návštěva grafitového dolu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg 207w," sizes="100vw" width="1600" height="1210"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Prohlídka města" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg 208w," sizes="100vw" width="1600" height="1200"><ul><li>C Vítkův kámen – pěší túra&nbsp;</li><li>D Individuální program&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>19:00 – 20:30 Večeře&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Večerní program" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>20:30 – ??? Společenský večer firmy <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> - Silent disco</h5><ul><li>Taneční večer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Společenský večer firmy Shimadzu - Silent disco" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg 245w," sizes="100vw" width="1600" height="900">

27. Škola MS 2026 - den 3

Nový grafenový inkoust pro výrobu levných a citlivých tištěných senzorů vyvinuli výzkumníci z CATRIN Univerzity Palackého ve spolupráci s kolegy z VŠB-Technické univerzity Ostrava a Univerzity Karlovy. Při přípravě inkoustu poprvé využili metodu atomárního inženýrství a díky navázaným atomům mědi jsou schopni detekovat velmi citlivě dopamin – neurotransmiter, který umožňuje přenos signálů mezi nervovými buňkami. Přístup <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">představený v časopise Advanced Science</a> má velké šance uplatnit se v lékařské diagnostice.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp 117w," sizes="100vw" width="1920" height="2560">Atomární inženýrství (single-atom engineering) umožňuje řídit chemickou reaktivitu materiálů na úrovni jednotlivých atomů. Jeho širšímu uplatnění v lékařské diagnostice však dosud bránil nedostatek atomárně upravených materiálů i absence na nich založených tisknutelných inkoustů.&nbsp;Nyní se vědcům podařilo vyvinout novou třídu atomárně dopovaných grafenových materiálů a také inkoust pro přípravu citlivých tištěných senzorů. Sázka na měď se vyplatila při detekci dopaminu, jehož sledování je důležité pro biomedicínský výzkum a vývoj pokročilých diagnostických technologií některých onemocnění včetně Alzheimerovy choroby.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp 117w," sizes="100vw" width="1920" height="2560">„Vyvinutý NGA-Cu inkoust umožňuje výrobu plně inkoustově tištěných udržitelných papírových elektrod s velmi nízkými náklady. Samotný senzor vyžaduje pouze 1,3 mikrogramu aktivního inkoustu, stojí přibližně jednu korunu a dával stabilní odezvu minimálně po dobu tří měsíců. Inkoust je navíc plně kompatibilní s běžně dostupnými inkoustovými materiálovými tiskárnami. To vytváří velký potenciál pro přípravu cenově dostupných, digitálně navržených senzorů, jejichž funkci lze přizpůsobovat atom po atomu,“ uvedl korespondující autor článku Michal Otyepka.Základem pro novou generaci atomárních inkoustů byla dusíkem dopovaná grafenová kyselina (NGA), kterou vědci z CATRIN vyvinuli před několika lety. Nyní ji postupně obohacovali různými jednotlivými atomy kovů včetně mědi, železa nebo manganu.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp 117w," sizes="100vw" width="1920" height="2560">„Ukázalo se, že elektrochemická odezva zásadně závisí na typu použitého atomu. Zatímco atomy mědi výrazně zesilují signál dopaminu, ostatní kovy jej naopak potlačují. Rozhodující&nbsp;tedy není jen samotná přítomnost izolovaných atomů kovu, ale také to, o jaký konkrétní kov se jedná. To je velmi důležitý poznatek pro další vývoj biosenzorů,“ objasnil první autor Martin-Alex Nalepa.Publikované výsledky představují novou třídu senzorických materiálů s velkým potenciálem v lékařské diagnostice. Vědci nabízí obecně využitelnou platformu pro vývoj grafenových inkoustů s jednotlivými atomy kovů a otevírají cestu ke škálovatelné, reprodukovatelné a materiálově úsporné výrobě pokročilých elektrochemických senzorů. „Jsme na začátku a fascinují nás nové možnosti, které se před námi otevírají. Vidíme, že změnou typu atomů můžeme řídit citlivost a selektivitu senzoru. Kromě dopaminu tak umíme velmi přesně stanovit například imunoglobuliny – protilátky, jejichž množství a typ mohou být důležitým ukazatelem autoimunitních nebo infekčních onemocnění,“ zdůraznil další z autorů článku Radek Zbořil.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp 117w," sizes="100vw" width="1920" height="2560">Elektrochemické biosenzory mohou nalézt uplatnění nejen v medicíně, ale také při kontrole kvality potravin, monitorování pitné vody nebo sledování znečištění životního prostředí. Jejich klíčovou součástí jsou funkcionalizované elektrody, pro jejichž výrobu se ukázaly jako velmi vhodné materiály právě na bázi grafenu. Základem úspěchu olomouckých vědců byla cílená příprava grafenového inkoustu s potřebnými vlastnostmi.Výzkum podpořil projekt TECHSCALE z operačního programu Jan Amos Komenský.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice: Projekt TECHSCALE (No.&nbsp;CZ.02.01.01/00/22_008/0004587) je financován z&nbsp;programu MŠMT&nbsp;OP&nbsp;JAK Špičkový výzkum, podpořeného z&nbsp;EFRR/ESF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg 245w," sizes="100vw" width="620" height="87"><blockquote><h4>Článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection</a></h4>Martin-Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendřišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal OtyepkaAdv. Sci., 2026, e76796<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/advs.76796">https://doi.org/10.1002/advs.76796</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>

Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice

Popularizace

Věda a výzkum

Video

Článek

Nejbližší akce

Škola hmotnostní spektrometrie je odborná vzdělávací akce pořádaná od roku 1986, která vedle zajímavých přednášek a kurzů nabízí i nespočet příležitostí k přátelským setkáním a diskusím.

Škola hmotnostní spektrometrie

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Noc vědců, akce oživující v jeden večer stovky vědeckých budov, do kterých se běžný smrtelník nedostane. Návštěvníci proplouvají laboratořemi, přednáškovými místnostmi, vybuchujícími experimenty a jdou do hloubky aktuálních témat. 

Noc vědců

The Analytical Scientist

Agilent Technologies

Technology Networks

Unchained Labs

VWR/Avantor

Shimadzu Corporation

Waters Corporation

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
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<li>I&#39;ve processed some samples, more than a few.
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<li>But between me and you, I had no idea all the things it could do!
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<li>And learn all the things your mass spec can do.
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A triple quad does more than just MRM. In this webinar the objective is to explore the different scan functions of a triple quad and how they can be used to solve complex problems. We will give examples of using the precursor ion and neutral loss scanning for lipid analysis. We will also talk about the unique mixed mode acquisition capability of the Agilent Ultivo Triple Quadrupole mass spectrometer, which allows for the sequential use of different acquisition modes in a single injection. Examples of field applications where mixed mode analysis would be fundamentally valuable will also be discussed.
<blockquote>
Presenter: Julie Cichelli, PhD (Agilent LC/MS applications Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Julie Cichelli obtained her Bachelor’s Degree from Villanova University in 2003 with a major in chemistry and a minor in mathematics. She went on to pursue graduate school at the University of Utah, studying under Dr. Zharov, completing her Ph.D. in Organic Chemistry in 2008. Following graduate school in 2009 she accepted a postdoctoral fellowship at the Huntsman Cancer Institute in Salt Lake City researching colon cancer under Dr. Stafforini and Dr. Topham. Subsequently, she joined the Agilent LC/MS applications team in 2010, with a focus in clinical and forensic applications.
</blockquote>
<blockquote>
Presenter: Sheher Banu Mohsin, Ph.D. (Senior Applications Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Sheher Mohsin is a senior applications scientist at Agilent Technologies. She received her Ph. D in physical chemistry from the University of Illinois and an MBA from Rockhurst University. She started her career at the US Environmental Protection Agency working on dioxin analysis with high resolution mass spectrometers. She later joined Bayer and worked in the special analysis lab using mass spectrometry to solve problems in synthesis, impurity determination and submission of final product impurity profile to regulatory agencies. Sheher’s current focus is on lipidomics using GC, LC and SFC separations and mass spectrometry. Sheher collaborates with academic and government researchers working on complex problems to come up with innovative, simplified workflows using the latest tools in separation and mass spectrometry.
</blockquote>

Agilent Technologies: Exploring the Different Scan modes of a Triple Quad beyond Just MRMs

Exploring the Different Scan modes of a Triple Quad beyond Just MRMs

In this webinar the objective is to explore the different scan functions of a triple quad and how they can be used to solve complex problems.

The Different Scan modes of a Triple Quad beyond Just MRMs

Interactions of analytes with metal surfaces in high-performance liquid chromatography (HPLC) instruments and columns have been reported to cause deleterious effects ranging from peak tailing to a complete loss of the analyte signal. These effects are due to the adsorption of certain analytes on the metal oxide layer on the surface of the metal components.
We have developed a novel surface modification technology and applied it to the metal components in ultra HPLC (UHPLC) instruments and columns to mitigate these interactions. A hybrid organic−inorganic surface, based on an ethylene-bridged siloxane chemistry, was developed for use with reversed-phase and hydrophilic interaction chromatography. We have characterized the performance of UHPLC instruments and columns that incorporate this surface technology and compared the results with those obtained using their conventional counterparts. 
We demonstrate improved performance when using the hybrid surface technology for separations of various small molecules as well as nucleotides, phosphopeptides, and oligonucleotides. The hybrid surface technology was found to result in higher and more consistent analyte peak areas and improved peak shape, particularly when using low analyte mass loads and acidic mobile phases. Reduced abundances of iron adducts in the mass spectrum of a peptide were also observed when using UHPLC systems and columns that incorporate hybrid surface technology. These results suggest that this technology will be particularly beneficial in UHPLC/mass spectrometry investigations of metal-sensitive analytes.
Join this session to:
<ul>
<li>Learn about non-specific adsorption and the challenges it can cause</li>
<li>Learn about current workarounds that scientists currently use to mitigate non-specific adsorption</li>
<li>Learn about MaxPeak HPS technology and how this prevent non-specific adsorption across many different workflows</li>
</ul>
<blockquote>
Presenter: Kim Haynes (Director of Chemistry Marketing and Product Management , Waters Corporation)
</blockquote>
<blockquote>
Kim Haynes is a Director of Chemistry Marketing and Product Management in the Consumables and Lab Automation Group at Waters Corporation. Kim manages MaxPeak High Performance Surface Technologies as well as a variety of other programs. Prior to this position, she has worked with Waters Corporation as a chemistry sales specialist and a business development manager.
</blockquote>
<blockquote>
During her 23 years at Waters, Kim has focused on helping scientists and colleagues understand chromatographic separations and sample preparation. Before joining Waters Corporation, Kim worked as an analytical chemist at Bacardi Martini. She holds a BS in Chemistry from Ohio University.
</blockquote>

The Analytical Scientist: Increasing method reproducibility by eliminating unwanted analyze surfaced interactions

Increasing method reproducibility by eliminating unwanted analyze surfaced interactions

Performance when using the hybrid surface technology for separations of various small molecules as well as nucleotides, phosphopeptides, and oligonucleotides. 

Reproducibility & eliminating unwanted surfaced interactions

Recent technological advancements have greatly expanded the options for high-quality mass spectrometry equipment. With significant progress in GC-MS, LC-MS, and gas generators, critical analyses can now be conducted with enhanced effectiveness and efficiency.
Join our technical webinar to gain a comprehensive overview of cutting-edge MS equipment and the latest innovations in utilizing hydrogen as a carrier gas. Discover the advancements, including Agilent&#39;s quadrupole time-of-flight LC-MS and PEAK Scientific&#39;s nitrogen gas generator, designed to optimize competitiveness and productivity in your analytical workflows.
<h5>Attend this webinar to:</h5>
<ul>
<li>Learn about why there is a huge drive to switch to hydrogen as a carrier gas for GC</li>
<li>Discover how to achieve time-saving efficiencies and meet future challenges with instrument intelligence using the latest quadrupole time-of-flight LC-MS</li>
<li>Understand how a gas generator can save you time and money as well as improve your lab’s sustainability</li>
</ul>
<h3>1. Novel Mass Spectrometry Technologies Expand Future of Biomarker Discovery Research</h3>
<ul>
<li>Diane Turner (Director and Senior Consultant, Anthias Consulting Ltd)</li>
</ul>
Gas chromatography - mass spectrometry (GC-MS) instruments are used for a wide variety of critical analyses and presents a topic of growing importance as the industry collectively moves away from helium as a carrier gas due to availability and pricing to suitable alternatives such as hydrogen.
In this webinar, Dr. Diane Turner from Anthias Consulting Ltd will focus on the innovations around using hydrogen as a carrier gas and explore the associated benefits as well as address the challenges involved.
<h5>In his talk, she will cover:</h5>
<ul>
<li>Why there is a huge drive to switch to hydrogen as a carrier gas for GC</li>
<li>The associated benefits and negatives of using hydrogen</li>
<li>A ‘to do’ list of parameters to re-optimize when switching to hydrogen</li>
</ul>
<h3>2. Be Ready for Future Challenges With an Intelligent LC-MS Solution</h3>
<ul>
<li>Christian Klein (Product Manager LC/Q-TOF and IM-QTOF, Agilent Technologies)</li>
</ul>
Many labs are faced with an ever-increasing sample load, while instrumentation and resources remain at a steady level. As a consequence, instrument throughput and uptime are critical factors to maintain competitiveness and productivity.
In this webinar, Dr. Christian Klein will show how you can meet these challenges with the newest time-of-flight LC-MS from Agilent. See examples of complete workflows demonstrating performance, robustness and throughput for food safety screening applications.
<h5>In his talk, he will cover:</h5>
<ul>
<li>Time-saving efficiencies and meeting future challenges with instrument intelligence</li>
<li>How to implement end-to-end workflows for food safety to produce meaningful results</li>
<li>How to identify and quickly assess compounds in question</li>
</ul>
<h3>3. How Can a Gas Generator Benefit Your Lab?</h3>
<ul>
<li>Petra Gierga (Product Manager, PEAK Scientific)</li>
</ul>
Labs face challenges every day and lab gas should not be one of these problems. On-site gas generators play a pivotal role in helping labs to streamline workflows while providing high-quality gas for LC-MS analysis.
In this webinar, Petra Gierga from PEAK Scientific will be discussing the benefits a gas generator can provide your lab over cylinders, dewars or bulk supply. Removing the need for repeated cylinder deliveries, cylinder contracts, manual handling and changing of cylinders – an in-house gas generator can reduce costs, increase productivity and improve your lab’s sustainability efforts.
<h5>In this talk, she will cover:</h5>
<ul>
<li>How a gas generator can save you time</li>
<li>The economic benefits of using a gas generator</li>
<li>The advantages a gas generator has for your labs workflows and long-term sustainability goals</li>
</ul>

Technology Networks: Breaking the Boundaries: The Latest Innovations in Mass Spectrometry

Breaking the Boundaries: The Latest Innovations in Mass Spectrometry

Technical webinar: overview of cutting-edge MS equipment and the latest innovations in utilizing H2 as a carrier gas, LC/Q-TOF or N2 gas generators.

The Latest Innovations in Mass Spectrometry

There is a lot of interest in adeno-associated viruses (AAVs), especially as vectors for gene therapy. AAVs are good candidates for this application due to their ability to infect both dividing and non-dividing cells without eliciting a strong immune response. Before AAV products can be released, they require unambiguous identification.
Agilent delivers total solutions for efficient AAV characterization and analysis while monitoring critical quality attributes.
This virtual event will provide you with expertise on:
<ul>
<li>LC/MS workflows for the identification of AAV capsid proteins and impurities</li>
<li>SEC workflows for aggregate and fragment analysis</li>
<li>IEX workflows to determine empty/full capsid ratios</li>
</ul>
Confirmed presentations
<ul>
<li>Introduction to the Analysis of Adeno-associated Virus Particles</li>
<li>AAV Capsid Protein Analysis using high resolution LC/MS</li>
<li>Multiple Peptide-Based Attributes of AAV with a Comprehensive LC/MS Method</li>
<li>Analytics of AAV based Gene Therapeutics</li>
</ul>
Who should attend?
<ul>
<li>Analytical development scientists</li>
<li>CDMO and CRO lab personnel</li>
<li>Biopharmaceutical scientists in process development</li>
</ul>

Agilent Technologies: Agilent AAV Workflow Summit: From Identity Confirmation to Aggregate Analysis

Agilent AAV Workflow Summit: From Identity Confirmation to Aggregate Analysis

Join us for half a day of virtual presentations on AAV analytical workflows

Agilent AAV Workflow Summit: From Confirmation to Analysis

Expansion of the MRM Toxicology Screening Methodology for Use With Waters Xevo TQ-S micro Tandem mass spectrometry has gained popularity over the years owing to its analytical sensitivity and selectivity, especially when used in MRM mode.
MRM can be used for quantitative analysis as well as targeted qualitative screening. Broad screening techniques that can detect a wide variety of toxicants in complex biological matrices are very much in demand in forensic toxicology laboratories.
At Waters, we have provided and supported, ready-to-implement MRM based toxicology screening solutions for almost two decades. 
This session will detail the further development of the popular Xevo TQ-S micro method and the expansion of the MRM Toxicology Screening Methodology which includes the addition of novel psychoactive substances (NPS) and other new drug classes.
Learning objectives – what you will learn:   
<ul>
<li>Expansion of the MRM nominal mass screening method</li>
<li>How the samples were prepared and data utilized</li>
<li>Total number of substances added and their drug classes</li>
</ul>
<blockquote>
Presenter: Nayan. S. Mistry (Senior Application Scientist, Forensics, Research &amp; Development, Waters Corporation, Waters Corporation)
</blockquote>
<blockquote>
Nayan Mistry is a Senior Application Scientist at Waters Corporation. Nayan joined Waters in 2009 and is part of a global team dedicated to performing research and development of applications and analytical solutions for Forensic Toxicology. 
</blockquote>
<blockquote>
Nayan’s key focus is on toxicology screening and he has expertise with both nominal mass and accurate mass-based screening using UNIFI and Waters_Connect application software. Nayan plays a key role in the development of these solutions and in the expansion of associated libraries. Currently Nayan is playing a key role in the development and support of the recently launched Xevo G3 QTof mass spectrometer in addition to other responsibilities for the nominal mass applications. His favourite aspect of the role is customer support - Nayan is greatly involved in global on-site customer support and training and has presented his work at conferences worldwide.
</blockquote>

Waters Corporation: Expanded Screening with a Nominal Mass Tandem Quadrupole System

Expanded Screening with a Nominal Mass Tandem Quadrupole System

This session will detail the further development of the popular Xevo TQ-S micro method and the expansion of the MRM Toxicology Screening Methodology.

Screening with a Nominal Mass Tandem Quadrupole MS

This webinar introduces an analytical method that utilizes ion-exchange chromatography to separate and analyze oligonucleotides of different lengths. The primary focus is on eliminating impurities that are produced during the synthesis process.
The method incorporates an inert ultra-high-performance liquid chromatography system, liquid chromatography-tandem mass spectrometry, and automated data analysis software. These components work together to facilitate efficient oligonucleotide development and quality control. The results emphasize the challenges associated with metal-based methods and propose a metal-free approach for precise quantification. Additionally, a high-resolution ion-pair reversed-phase LC-MS system is presented for accurate separation and mass analysis of oligonucleotides. The developed method also offers sensitive, precise, and reproducible results, making it an invaluable tool for various scientific fields, including therapeutic oligonucleotide-based drug development and quality control.
<blockquote>
Speaker: Mridul Mandal, Ph.D.
</blockquote>
<blockquote>
Marketing Manager, Shimadzu Scientific Instruments Mridul Mandal, Ph.D. is currently working as a market manager -pharma/biopharma at Shimadzu Scientific Instruments. Before entering this position, he held numerous roles in academia and pharma CRO for over 12 years. He has published over 30 peer-reviewed publications and book chapters on mass spectrometry, chromatography, and other instrumentation in biomedical science
</blockquote>

Shimadzu: Oligonucleotide Analysis by LC and LC-MS

Oligonucleotide Analysis by LC and LC-MS

This webinar introduces an analytical method that utilizes ion-exchange chromatography to separate and analyze oligonucleotides of different lengths.

Involved in developing oligonucleotide therapeutics? Oligonucleotides have attracted increasing attention in the development of direct therapeutic agents against a wide range of disease conditions.
The analysis of oligonucleotide therapeutics requires robust and accurate analytical characterization to confirm identity, and to determine purity, quality, and strength.
<h5>During this webinar, Thermo Scientific’s Ken Cook will examine developments and tips for:</h5>
<ul>
<li>Column chemistry to fully sequence a 100mer by LCMS/MS and HCD fragmentation
</li>
<li>A method to monitor IVT reactions by rapid UHPLC
</li>
<li>Observe disterio-isomer profiles in siRNA and ASO RNA
</li>
<li>Change separation selectivity in ion exchange and ion pair reverse phase chromatography of oligonucleotides with eluent choice and oligonucleotides with pH
</li>
<li>Methods for strand ratio determination with double stranded oligonucleotides
</li>
</ul>
Thermo Scientific has over 20 years of innovations and publications around the separation of oligonucleotides, please join our webinar to learn how the DNAPac family of Ion Exchange and Reversed Phase columns can optimize and enhance your nucleic acid separations. The session will finish with a short Q&amp;A and include a live chat with an expert.
<blockquote>
Presenter: Dr. Ken Cook
</blockquote>
<blockquote>
Dr. Ken Cook began his career in academia as a Biochemistry lecturer focused on protein chemistry and metabolism. Today, with well over 30 years’ industry experience working for Dionex, then Thermo Fisher Scientific, his vast knowledge supporting and developing solutions within chromatography brand him a bio-separations expert. 
</blockquote>
<blockquote>
Currently, his work involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide-based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Methods for the characterisation of therapeutic proteins include peptide mapping by LC/HRMS. Developments in charged variant analysis including novel coupling to MS, Glycan analysis, Aggregate analysis and on-line process monitoring. Gene therapy characterisation is a growing interest which has had much success. 
</blockquote>
<blockquote>
Given his immense experience, it is an honour to have Ken share his knowledge.
</blockquote>

Avantor: New Developments and Tips for Oligonucleotide Analyses

New Developments and Tips for Oligonucleotide Analyses

Topics: Column chemistry to fully sequence a 100mer by LCMS/MS and HCD fragmentation; A method to monitor IVT reactions by rapid UHPLC...

This webinar introduces an analytical method that utilizes ion-exchange chromatography to separate and analyze oligonucleotides of different lengths.
The primary focus is on eliminating impurities that are produced during the synthesis process. The method incorporates an inert ultra-high-performance liquid chromatography system, liquid chromatography-tandem mass spectrometry, and automated data analysis software. These components work together to facilitate efficient oligonucleotide development and quality control. The results emphasize the challenges associated with metal-based methods and propose a metal-free approach for precise quantification. Additionally, a high-resolution ion-pair reversed-phase LC-MS system is presented for accurate separation and mass analysis of oligonucleotides. The developed method also offers sensitive, precise, and reproducible results, making it an invaluable tool for various scientific fields, including therapeutic oligonucleotide-based drug development and quality control.
<blockquote>
Presenter: Mridul Mandal, Ph.D.
</blockquote>

Shimadzu: Oligonucleotide Analysis by LC and LC and LC-MS

Oligonucleotide Analysis by LC and LC and LC-MS

Analytical method that utilizes ion-exchange chromatography to separate and analyze oligonucleotides of different lengths.

<h5>The Problem</h5>Buffer exchange is a critical step to developing optimal vectors and payloads. Compared to biologics, development of delivery vectors like lipid nanoparticles (LNPs) and adeno-associated viruses (AAVs) is a newer research area with different challenges and opportunities to address. LNPs require fast buffer exchange to remove any organic phase without disrupting encapsulation efficiency or causing size change. AAVs usually need concentration after manufacturing in addition to buffer exchange at a high recovery. Both vectors can vary wildly in their manufacturing conditions or serotype, meaning a single solution may not be the best fit.<h5>The Solution</h5>Unagi is a benchtop automated buffer exchange and concentration instrument designed to handle a wide range of biologics and gene therapy biomolecules. Using pressure based ultra-filtration/diafiltration (UF/DF) technology coupled with non-contact individual sample volume measurement, Unagi will deliver precise buffer exchange and concentration targets without putting a dent in your sample recovery. With the ability to parallel process 1-8 samples in a volume range between 0.5 – 48 mL, Unagi can help with screening, formulation, quality control, and analytical prep workflows. Programmable settings, including the optional orbital mixing, can be used with default settings, or customized to your unique nucleic acid, AAV, and LNP samples.<h5>The Proof</h5>Join us to see firsthand data results demonstrating the power and flexibility of Unagi for nucleic acids, LNPs, and AAVs. Final exchange and concentration values, along with analytic characterization, will be shown under different conditions.<blockquote>Presenter:&nbsp;Del Ray Jackson (Market Manager, Buffer Exchange &amp; Automation, Unchained Labs)Moderator: Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.</blockquote>

Unchained Labs: Power up your LNP & AAV sample prep with Unagi

Power up your LNP & AAV sample prep with Unagi

Join us to see firsthand data results demonstrating the power and flexibility of Unagi for nucleic acids, LNPs, and AAVs. 

<h5>The Problem</h5>Manual buffer exchange methods take up tons of your precious time and are a pain to manage in large numbers - often leaving you with inconsistent results and playing catch up to meet your deadlines.<h5>The Solution</h5>Big Tuna is a fully automated buffer exchange platform that can exchange and concentrate up to 96 samples in parallel – with just 30 minutes of setup. By automating the previously painful and error prone process of buffer exchange and concentration, Big Tuna gives researchers the consistent sample handling, degrees of process control and throughput that just aren’t possible with manual methods.<h5>The Proof</h5>Tune in to learn how Big Tuna has helped tons of labs and CDMOs smash their buffer exchange bottlenecks for proteins, mAbs, nucleic acids, AAVs and LNPs. We will show formulation case studies for both mAbs and AAVs that will showcase the type of real recovery results of less than 96% you can expect from automating your buffer exchange with Big Tuna.<blockquote>Presenter:&nbsp;Del Ray Jackson (Market Manager, Buffer Exchange &amp; Automation, Unchained Labs)Moderator: Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.</blockquote>

Unchained Labs: Chuck the buffer exchange time suck with Big Tuna

Chuck the buffer exchange time suck with Big Tuna

Tired of manual buffer exchange? Learn how Big Tuna automates up to 96 samples, saving time and boosting consistency for proteins, mAbs, AAVs, and more.