Noc vědy 2026 - Komunikace

Třetí den <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/all/events/930">27. Školy hmotnostní spektrometrie</a>, středa 23. září 2026, se dopoledne nesl ve znamení omických přístupů a metod, které posouvají možnosti běžné LC-MS analýzy. Zdeněk Spáčil otevřel program přehledem akvizičních strategií od full scanu a MS/MS přes DDA, DIA/SWATH a PRM/MRM až po HRMS, na který Jaroslava Friedecká navázala tématem společného vyhodnocování metabolomických, proteomických a lipidomických dat. Sekce „Za hranicemi rutinní MS“ pak ukázala další směry současné hmotnostní spektrometrie: Pavel Hrouzek představil využití stabilních izotopů při studiu metabolických drah, Robert Jirásko se zaměřil na iontovou mobilitu v LC/MS při analýze malých molekul a dopolední odborný blok uzavřela přednáška společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> věnovaná ionizační technologii <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/lcms/library?mainauthorItems=53&amp;search=SICRIT">SICRIT®</a>.Po intenzivním odborném programu přišlo na řadu tradiční kulturně-poznávací odpoledne. Účastníci si mohli vybrat mezi návštěvou Vyššího Brodu a tamního kláštera, výletem do Českého Krumlova spojeným s prohlídkou grafitového dolu, pěší túrou na Vítkův kámen nebo individuálním programem, jehož součástí byl také turnaj ve stolním fotbálku. Večer pak třetí konferenční den pokračoval společenským programem společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>, tentokrát v podobě Silent disco a tanečního večera.<h3>Program</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/program_Skola_MS_2026_final_8c8cf90056.pdf">Finální program 27. Školy MS je ke stažení zde</a></blockquote><h4>Středa, 23. 9. 2026</h4><h5>SEKCE VII. Od MS k omikám</h5><h5>08:30 – 09:15 Strategie akvizice v LC-MS: full scan vs. MS/MS, DDA vs. DIA (SWATH), PRM/MRM, HRMS&nbsp;</h5><ul><li>Zdeněk Spáčil&nbsp;</li></ul><h5>09:15 – 10:00 Kombinovaná analýza metabolomických, proteomických a lipidomických dat&nbsp;</h5><ul><li>Jaroslava Friedecká&nbsp;</li></ul><h5>10:00 – 10:30 Přestávka na kávu&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Waters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Phenomenex" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>SEKCE VIII. Za hranicemi rutinní MS&nbsp;</h5><h5>10:30 – 11:00 Od izotopové obálky k metabolickým drahám: využití stabilních izotopů při studiu primárního metabolismu a biosyntézy specializovaných metabolitů&nbsp;</h5><ul><li>Pavel Hrouzek&nbsp;</li></ul><h5>11:00 – 11:30 Současné techniky iontové mobility v LC/MS a jejich využití při analýze malých molekul&nbsp;</h5><ul><li>Robert Jirásko&nbsp;</li></ul><h5>11:30 – 12:00 <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>: SICRIT®: Nová dimenze v MS ionizaci&nbsp;</h5><ul><li>Jan Buček</li></ul><h5>12:00 – 13:30 Oběd&nbsp;</h5><h5>KULTURNĚ POZNÁVACÍ ODPOLEDNE&nbsp;</h5><ul><li>A Vyšší Brod – procházka městem, prohlídka kláštera&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg 233w," sizes="100vw" width="1600" height="1072"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg 208w," sizes="100vw" width="1600" height="1201"><ul><li>B Český Krumlov – prohlídka města, grafitový důl&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Návštěva grafitového dolu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg 207w," sizes="100vw" width="1600" height="1210"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Prohlídka města" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg 208w," sizes="100vw" width="1600" height="1200"><ul><li>C Vítkův kámen – pěší túra&nbsp;</li><li>D Individuální program&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>19:00 – 20:30 Večeře&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Večerní program" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>20:30 – ??? Společenský večer firmy <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> - Silent disco</h5><ul><li>Taneční večer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Společenský večer firmy Shimadzu - Silent disco" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg 245w," sizes="100vw" width="1600" height="900">

27. Škola MS 2026 - den 3

Nový grafenový inkoust pro výrobu levných a citlivých tištěných senzorů vyvinuli výzkumníci z CATRIN Univerzity Palackého ve spolupráci s kolegy z VŠB-Technické univerzity Ostrava a Univerzity Karlovy. Při přípravě inkoustu poprvé využili metodu atomárního inženýrství a díky navázaným atomům mědi jsou schopni detekovat velmi citlivě dopamin – neurotransmiter, který umožňuje přenos signálů mezi nervovými buňkami. Přístup <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">představený v časopise Advanced Science</a> má velké šance uplatnit se v lékařské diagnostice.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp 117w," sizes="100vw" width="1920" height="2560">Atomární inženýrství (single-atom engineering) umožňuje řídit chemickou reaktivitu materiálů na úrovni jednotlivých atomů. Jeho širšímu uplatnění v lékařské diagnostice však dosud bránil nedostatek atomárně upravených materiálů i absence na nich založených tisknutelných inkoustů.&nbsp;Nyní se vědcům podařilo vyvinout novou třídu atomárně dopovaných grafenových materiálů a také inkoust pro přípravu citlivých tištěných senzorů. Sázka na měď se vyplatila při detekci dopaminu, jehož sledování je důležité pro biomedicínský výzkum a vývoj pokročilých diagnostických technologií některých onemocnění včetně Alzheimerovy choroby.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp 117w," sizes="100vw" width="1920" height="2560">„Vyvinutý NGA-Cu inkoust umožňuje výrobu plně inkoustově tištěných udržitelných papírových elektrod s velmi nízkými náklady. Samotný senzor vyžaduje pouze 1,3 mikrogramu aktivního inkoustu, stojí přibližně jednu korunu a dával stabilní odezvu minimálně po dobu tří měsíců. Inkoust je navíc plně kompatibilní s běžně dostupnými inkoustovými materiálovými tiskárnami. To vytváří velký potenciál pro přípravu cenově dostupných, digitálně navržených senzorů, jejichž funkci lze přizpůsobovat atom po atomu,“ uvedl korespondující autor článku Michal Otyepka.Základem pro novou generaci atomárních inkoustů byla dusíkem dopovaná grafenová kyselina (NGA), kterou vědci z CATRIN vyvinuli před několika lety. Nyní ji postupně obohacovali různými jednotlivými atomy kovů včetně mědi, železa nebo manganu.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp 117w," sizes="100vw" width="1920" height="2560">„Ukázalo se, že elektrochemická odezva zásadně závisí na typu použitého atomu. Zatímco atomy mědi výrazně zesilují signál dopaminu, ostatní kovy jej naopak potlačují. Rozhodující&nbsp;tedy není jen samotná přítomnost izolovaných atomů kovu, ale také to, o jaký konkrétní kov se jedná. To je velmi důležitý poznatek pro další vývoj biosenzorů,“ objasnil první autor Martin-Alex Nalepa.Publikované výsledky představují novou třídu senzorických materiálů s velkým potenciálem v lékařské diagnostice. Vědci nabízí obecně využitelnou platformu pro vývoj grafenových inkoustů s jednotlivými atomy kovů a otevírají cestu ke škálovatelné, reprodukovatelné a materiálově úsporné výrobě pokročilých elektrochemických senzorů. „Jsme na začátku a fascinují nás nové možnosti, které se před námi otevírají. Vidíme, že změnou typu atomů můžeme řídit citlivost a selektivitu senzoru. Kromě dopaminu tak umíme velmi přesně stanovit například imunoglobuliny – protilátky, jejichž množství a typ mohou být důležitým ukazatelem autoimunitních nebo infekčních onemocnění,“ zdůraznil další z autorů článku Radek Zbořil.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp 117w," sizes="100vw" width="1920" height="2560">Elektrochemické biosenzory mohou nalézt uplatnění nejen v medicíně, ale také při kontrole kvality potravin, monitorování pitné vody nebo sledování znečištění životního prostředí. Jejich klíčovou součástí jsou funkcionalizované elektrody, pro jejichž výrobu se ukázaly jako velmi vhodné materiály právě na bázi grafenu. Základem úspěchu olomouckých vědců byla cílená příprava grafenového inkoustu s potřebnými vlastnostmi.Výzkum podpořil projekt TECHSCALE z operačního programu Jan Amos Komenský.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice: Projekt TECHSCALE (No.&nbsp;CZ.02.01.01/00/22_008/0004587) je financován z&nbsp;programu MŠMT&nbsp;OP&nbsp;JAK Špičkový výzkum, podpořeného z&nbsp;EFRR/ESF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg 245w," sizes="100vw" width="620" height="87"><blockquote><h4>Článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection</a></h4>Martin-Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendřišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal OtyepkaAdv. Sci., 2026, e76796<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/advs.76796">https://doi.org/10.1002/advs.76796</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>

Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice

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Věda a výzkum

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Článek

Nejbližší akce

Škola hmotnostní spektrometrie je odborná vzdělávací akce pořádaná od roku 1986, která vedle zajímavých přednášek a kurzů nabízí i nespočet příležitostí k přátelským setkáním a diskusím.

Škola hmotnostní spektrometrie

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Noc vědců, akce oživující v jeden večer stovky vědeckých budov, do kterých se běžný smrtelník nedostane. Návštěvníci proplouvají laboratořemi, přednáškovými místnostmi, vybuchujícími experimenty a jdou do hloubky aktuálních témat. 

Noc vědců

New Food magazine

Separation Science

Metrohm

Technology Networks

Thermo Fisher Scientific

VWR/Avantor

SCIEX

Evosep Biosystems

Join this webinar to hear from Dr. Karl Oetjen and Dr. Craig Butt, who will share their recent research on nontargeted analysis of food products.
Discover how advanced analytical methods can detect unlisted, unexpected, and unwanted ingredients, leading to increased confidence throughout the supply chain, ultimately benefiting consumers.
This webinar looks at several sample types in the application of diagnostic ion screening to prioritise nontarget features for food safety analysis. Data from this study includes the analysis of supplements products from North American Gas Stations to determine what are the actual ingredients that “boost metabolism”, “elevates mood” and supply “good luck energy”. This study also looks at saffron and its origins along with an update on nontargeted screening of pesticides in food samples.
Discover the ingredients behind marketing slogans.
<ul>
<li>Understand why ZenoTOF technology is at the forefront of detecting the unknown, unexpected and unwanted at trace levels.
</li>
<li>Discover how mass spectrometry can be used to determine authenticity of expensive ingredients.
</li>
<li>Learn how nontargeted workflows can test the regulated and the non-regulated in pesticide assays.
</li>
<li>A chance to ask our expert speakers questions and these exciting workflows.
</li>
</ul>
<blockquote>
Presenter: Karl Oetjen (Senior Scientist, Technical Marketing, SCIEX)
</blockquote>
<blockquote>
Karl Oetjen is a Senior Scientist at SCIEX in the technical marketing group and has over 10 years of mass spectrometry experience. Before joining SCIEX, he completed his PhD at Colorado School of Mines (Golden, Colorado) in Hydrologic Science and Engineering under Dr. Chris Higgins. Karl’s dissertation research focused on nontarget characterisation of complex surfactant mixtures, including aqueous film forming foams. This work led to the discovery several novel per- and polyfluorinated alkyl substances (PFAS) that since have been found in variety of environmental samples and industrial chemicals. Since joining SCIEX, Karl has worked with numerous labs creating and implementing both regulated and unregulated quantitative and qualitative screening methods. 
</blockquote>
<blockquote>
Presenter: Craig Butt (Manager, Applied Markets, SCIEX)
</blockquote>
<blockquote>
Craig M. Butt is Manager of the Applied Markets group in the Global Technical Marketing division of SCIEX with over 20 years of mass spectrometry experience. Previously at SCIEX he was an applications scientist where he developed methods for targeted and non-targeted methods in the cannabis, environmental, food and beverage group. He obtained his Ph.D. in environmental chemistry at the University of Toronto, his thesis research investigated the fate of poly- and perfluorinated organic compounds (PFAS) in biological systems. He was a NSERC post-doctoral research fellow in the Nicholas School of the Environment at Duke University, later becoming a research scientist in the department.
</blockquote>

New Food:Enhancing food safety analysis with diagnostic Ion screening

Enhancing food safety analysis with diagnostic Ion screening

Several sample types in the application of diagnostic ion screening to prioritise nontarget features for food safety analysis.

Exposomics research studies the impact of environmental factors, including exposure to contaminants, on health.
Untargeted workflows for metabolomics and exposomics typically report hundreds of features belonging to diverse compound classes, identified with varying levels of confidence.
In this webinar, our expert speaker will discuss how to optimize your untargeted approaches on Zeno SWATH DIA using a modular workflow. With this approach, each subset of the full mass range can be individually adjusted to meet project-specific and user-defined goals, enhancing the performance and adaptability of untargeted MS tools for exposomics research.
Attend this webinar to: 
<ul>
<li>Discover exposomics, the insights it provides into human health and the role of mass spectrometry in this field
</li>
<li>Learn a rational approach to optimize chromatography and mass spectrometry parameters
</li>
<li>Make your method development efforts modular so they can be reused to meet different project-specific needs
</li>
<li>Find out how using Zeno SWATH DIA can benefit your metabolomics or exposomics research.
</li>
</ul>
<blockquote>
Presenter: Dr. Cristina Balcells Nadal (Research Associate, Imperial College London)
</blockquote>

Technology Networks: Optimizing SWATH-DIA for Exposomics and Metabolomics

Optimizing SWATH-DIA for Exposomics and Metabolomics

How to optimize your untargeted approaches on Zeno SWATH DIA using a modular workflow.

The 1st key-note presentation will explore the pursuit of enhanced chromatographic performance in low-flow applications.
Microfluidic pillar array columns offer a compelling alternative to traditional packed beds and monolithic columns, resulting in microfluidic separation beds with nanometer-scale control over geometry, enhancing quantitation accuracy and precision. The presentation focuses on a 5.5 cm separation channel housing radially elongated rectangular pillar shapes, ideal for high-throughput chromatographic separations. Integrated with advanced LC-MS instruments, the Vanquish Neo UHPLC system, and the latest Orbitrap mass spectrometers, this configuration achieves unparalleled quantitation accuracy and precision, handling up to 300 samples daily. 
The second part will take us to detection technologies. HPLC has seen the advent and often also decline of various techniques which were claimed to enable universal detection. The emphasis will be on the use of an instrumental technique that was published specifically for charged aerosol detection (CAD) and is referred to as inverse gradient with the goal to widely eliminate the influence of the mobile phase composition on the analyte response. Practical examples will address extractables &amp; leachables, but also very common excipients in biopharmaceutical formulations. The method uses multiple orthogonal detectors (UV, CAD, MS) combined with the inverse gradient technique to facilitate analysis of a chemically diverse range of analytes. 
Learning points:
<ul>
<li>How to achieve unparalleled quantitation accuracy and precision in high-throughput chromatographic separations 
</li>
<li>Detection technologies
</li>
</ul>
Who should attend:
<ul>
<li>Lab managers and directors 
</li>
<li>Principal scientists 
</li>
<li>Laboratory analysts
</li>
</ul>

Thermo Scientific: Leveraging innovative stationary phase architectures and multi-detection strategies in biopharma and proteomics research to enhance precision, efficiency, and results

Leveraging innovative stationary phase architectures and multi-detection strategies in biopharma and proteomics research to enhance precision, efficiency, and results

We will explore the pursuit of enhanced chromatographic performance in low-flow applications. The second part will take us to detection technologies.

Stationary phase & multi-detection in biopharma & proteomics

This webinar is your guide to get started with a fast and efficient, automated sample preparation protocol on the Opentrons OT-2.
Utilize protein aggregation capture (PAC) on magnetic microparticles in an end-to-end standardized and hands-off workflow, starting from protein lysate or plasma to peptide loaded on Evotips.
<h4>Why choose an automated workflow?</h4>
Automated sample preparation workflows have become a popular tool in proteomics laboratories for a number of reasons. With increased sample throughput on the Evosep One, you can prioritize numerous technical and biological replicates, adding robustness to downstream bioinformatic analyses.
By adopting full automation, you can gain precise control over protocols, ensuring reproducibility across samples and experiments. This minimizes batch effects, resulting in more reliable data for analysis and interpretation.
Furthermore, enhanced automation significantly reduces manual labor, enhancing reproducibility and providing researchers with more time for critical decision-making. This workflow also proves cost-efficient for large-scale applications, optimizing protein input for digestion.
<h4>AUTOMATED WORKFLOW FOR INTEGRATED SAMPLE DIGESTION AND EVOTIP LOADING FOR HIGH-THROUGHPUT CLINICAL PROTEOMICS</h4>
<blockquote>
Presenter: Anders H.Kverneland (MD &amp; Postdoctoral researcher at Center for Cancer Immune Therapy, Herlev hospital)
</blockquote>
Protein identification and quantification is an important tool for biomarker discovery. With the increased sensitivity and shortened the analysis tim​e of modern mass spectrometers, sample-preparation remains a bottleneck and source of variability when studying large cohorts. To address this issue, we evaluated the use of a simple integrated workflow on the Opentrons OT-2 robot enabling both sample digestion and Evotip loading. Our results demonstrate high sensitivity combined with both reproducibility and stability even with very low sample inputs. The integration of the digestion and Evotip loading also strongly reduced the amount of reagents needed for the sample preparation. Using the integrated workflow, we evaluate the effects of cancer immune therapy on the plasma proteome in metastatic melanoma patients.
<h4>STANDARDIZED AND FULLY AUTOMATED DEEP PROTEOME PROFILING OF PLASMA INTEGRATED WITH EVOSEP ONE ENABLES LARGE-SCALE CLINICAL COHORT ANALYSIS</h4>
<blockquote>
Presenter: Dorte Becker-Jensen (Application Manager at Evosep)
</blockquote>
This streamlined end-to-end workflow enables deep plasma profiling through the automated enrichment of membrane-bound vesicles and depletion of abundant proteins from a mere 4 μl of plasma. Integrated with the SCIEX ZenoTOF, it consistently identifies more than 3,500 protein groups, all with the ease of processing 30 samples per day at the push of a button.

Evosep: Elevate efficiency: The power of automation

Elevate efficiency: The power of automation

Get started with a fast and efficient, automated sample preparation protocol on the Opentrons OT-2.

The pH value is one of the most important and therefore also one of the most frequently measured parameters in analytical chemistry.
Sometimes, a simple pH test strip will do for a quick check; however, a precise pH meter and the right choice of the pH electrode are a must when reliable results are needed. 
In our educational webinar on November 14, Doris Hoffmann, Product Manager at the Competence Center Titration at Metrohm International Headquarters, will show you that the determination of the pH value can be quite simple, if you pay attention to a few critical details. 
Whether you perform a pH measurement for the first time or are a routine user, we are sure there is room for improvement. Join this webinar and make the next step towards higher accuracy and better reproducibility of your pH measurement results.
Register &amp; participate in this webinar to learn:
<ul>
<li>What the pH value is and how it is measured
</li>
<li>The functional components and design of a pH electrode
</li>
<li>Which kind of pH electrode is suitable for which application
</li>
<li>What parameters are determined during a pH calibration, and what values are acceptable
</li>
<li>How to properly care for and maintain a pH electrode
</li>
</ul>
<blockquote>
Presenter: Doris Hoffmann (Product Manager at CC Titration, Metrohm International Headquarters)
</blockquote>
<blockquote>
Doris Hoffmann has studied chemistry and has specialized in analytical chemistry and electrochemistry in her Master`s degree. She joined Metrohm International Headquarters in 2021 as a Product Manager and is responsible for the extensive portfolio of Metrosensors including pH electrodes, electrodes for titration, and more.
</blockquote>

Metrohm: The basics of precise pH measurement

The basics of precise pH measurement

The determination of the pH value can be quite simple, if you pay attention to a few critical details.

PFAS, or per- and polyfluoroalkyl substances, have primarily been studied in the context of environmental contamination, but recent developments have led to exploring their impact in diverse areas such as food, bioclinical settings, personal care products, and pharmaceuticals.
This expert panel discussion will explore the lessons learned from environmental applications and how these insights can be transitioned to these other arenas. The conversation will navigate through the current challenges faced, examine technologies at our disposal, pinpoint unmet analytical needs, and map out next steps. In addition, an overview of the ever-evolving regulatory landscape will provide an important backdrop for the discussion.
By attending this presentation, you will:
<ul>
<li>Gain an understanding of the challenges involved when transitioning from environmental matrices.
</li>
<li>Recognize the current analytical solutions available and identify gaps that present opportunities for innovation.
</li>
<li>Understand the complexities and challenges in the regulatory landscape concerning PFAS analysis across diverse sectors.
</li>
<li>Be better equipped to develop an action plan for next steps in the journey of expanding PFAS analysis beyond its traditional environmental context.
</li>
</ul>
Who should attend
<ul>
<li>Anyone involved in PFAS analysis, method development, or research should consider joining this webinar. Questions outside the scope of the description are welcome and will be addressed if time allows.</li>
</ul>
<blockquote>
Presenter: Rock J. Vitale (Technical Director of Chemistry, Senior Principal at Environmental Standards, Inc.)
</blockquote>
<blockquote>
Mr. Vitale has over 40 years of analytical and QA experience. Specifically, he has six years of analytical experience performing analyses for organic and inorganic contaminants in a variety of media by instrumental and classical methods, including research and development of analytical methodologies. As a Principal of Environmental Standards, Mr. Vitale oversees a staff of approximately 40 QA Chemists - one of the nation’s largest. He is a recognized expert in the following fields: organic and inorganic analysis and data quality assessment (including high-resolution PCBs, dioxins/furans, and PFAS); laboratory auditing; preparation or third-party review of QAPPS for complex analytical programs; methods development to accommodate project-specific data quality objectives (DQOs); design of QA programs; and agency negotiations.
</blockquote>
<blockquote>
Presenter: Olga Shimelis (Analytical Chemistry R&amp;D Manager at the life science business of Merck KGaA, Darmstadt, Germany)
</blockquote>
<blockquote>
Dr. Olga Shimelis worked for MilliporeSigma in multiple R&amp;D roles at the Bellefonte, PA, USA site in the area of development of consumables for chromatographic separations. Olga holds a Ph.D. in Analytical Chemistry from the University of Oklahoma, USA.
</blockquote>
<blockquote>
Presenter: Emiliano De Dominicis (Chemistry Research Director at Mérieux NutriSciences Italia)
</blockquote>
<blockquote>
Emiliano is a researcher with over twenty years of experience in food and pharmaceutical safety, following both private and academic sectors, and he is now Director of Chemical Research - Project Manager at Mérieux NutriSciences. With a team dedicated to Research and Development in Analytical Chemistry, Emiliano is responsible for Mérieux NutriSciences&#39; R&amp;D lab, taking part in global research projects. Moreover, he actively participates in funded scientific projects (regional, national, and European) and scientific congresses as a speaker, and writes articles published in specialized scientific journals.
</blockquote>
<blockquote>
Presenter: Ruth Marfil-Vega (Senior Market Manager, Environmental at Shimadzu Scientific Instruments)
</blockquote>
<blockquote>
Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants. Ruth has continued working with environmental stakeholders since she joined Shimadzu five years ago to make sure that analytical instrumentation and workflows enable their success. She graduated from the University of Valladolid (Spain) with a BSc in Chemistry, and from the University of Cincinnati with a PhD in Environmental Science and Engineering.
</blockquote>
<blockquote>
Presenter: Erin Baker (Associate Professor at the University of North Carolina at Chapel Hill)
</blockquote>
<blockquote>
Erin S. Baker is an Associate Professor at the University of North Carolina at Chapel Hill. To date, she has published over 160 peer-reviewed papers utilizing different analytical chemistry techniques to study both environmental and biological systems. Over the last four years, Erin also helped grow the Females in Mass Spectrometry group, where she served as the Events Committee Chair from 2019-2022. She is currently serving as the Vice President of Education for the International Lipidomics Society, a mentor for Females in Mass Spectrometry, and an Associate Editor for the Journal of the American Society for Mass Spectrometry.
</blockquote>

Separation Science: Expanding PFAS Analysis Beyond Environmental Matrices

Expanding PFAS Analysis Beyond Environmental Matrices

Explore the lessons learned from environmental applications and how these insights can be transitioned to these other arenas.

Are you looking to transform your organization’s digital landscape? Does digital transformation seem like something that you aren’t able to attain just yet?
Join us for an engaging webinar where we delve into the Thermo Scientific Ardia Platform, a game-changing solution for scientists seeking to unlock the full potential of their data. This session will provide a comprehensive overview of the Ardia Platform, showcasing its advanced data analysis and connectivity capabilities. Explore how the Ardia Platform can accelerate your scientific discoveries, streamline your workflows, and enable you to make data-driven decisions with confidence. Don&#39;t miss this opportunity to revolutionize your research with the Ardia Platform.
Who should attend?
<ul>
<li>Researchers looking to better analyze their chromatography and mass spectrometry data </li>
<li>Anyone involved with driving digital transformation in their organization </li>
<li>Lab managers, IT professionals, laboratory system administrators, and business leaders</li>
</ul>
 What you will learn?
<ul>
<li>How the Ardia Platform offers connectivity, scalability, and security
</li>
<li>Core applications of the Ardia Platform
</li>
</ul>
<blockquote>
Presenter: Larry West (Senior Enterprise Software Solution Sales Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Larry has worked with chromatography data systems for over 40 years. Today he is part of the Thermo Enterprise CDS Team and supports Chromeleon. He holds a bachelor’s degree in chemistry and began his work in chromatography at Whatman Inc in 1981. He enjoys the whole process of streamlining the needs of chromatographers to make their user experience the best it can be.
</blockquote>

Thermo Scientific: Simplifying digital transformation with the Thermo Scientific Ardia Platform

Simplifying digital transformation with the Thermo Scientific Ardia Platform

Thermo ScientificTM ArdiaTM Platform, a game-changing solution for scientists seeking to unlock the full potential of their data.

Digital transformation - Thermo Scientific Ardia Platform

Discover the ground-breaking technology that promises a whole new level of chromatographic performance in low-flow applications, making you rethink what&#39;s possible.
First, we&#39;ll show you how the latest advancements in column technology seamlessly integrate with the Vanquish Neo UHPLC system and cutting-edge Orbitrap mass spectrometers. Imagine achieving unparalleled accuracy and precision while handling up to 300 samples daily – this is the future of high-throughput chromatographic separations.
The 2nd Keynote part explores the ever-evolving landscape of HPLC detection techniques – specifically around universal detection! We’ll discuss what universal detection really means, delve into the power of Charged Aerosol Detection (CAD) and what advantages inverse gradient can bring to your analysis. This will all be demonstrated with practical examples addressing extractables &amp; leachables along with common biopharmaceutical excipients.
Learning points:
<ul>
<li>How to achieve unparalleled quantitation accuracy and precision in high-throughput chromatographic separations 
</li>
<li>Detection technologies
</li>
</ul>
Who should attend:
<ul>
<li>Lab managers and directors 
</li>
<li>Principal scientists 
</li>
<li>Laboratory analysts
</li>
</ul>
<blockquote>
Presenter: Katherine Lovejoy (Product Applications Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Katherine Lovejoy, Ph.D. has been an application chemist focusing on charged aerosol detection at the Thermo Fisher Scientific HPLC factory site since 2016 and has a Ph.D. in inorganic chemistry from the Massachusetts Institute of Technology. She has experience as a chemist reviewer at the FDA and as a scientist at Los Alamos National Laboratory.
</blockquote>
<blockquote>
Presenter: Mauro De Pra (Product Application Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Mauro De Pra is Product Application Manager at Thermo Fisher Scientific. Since he joined the company in 2010, he focused on product development, application development and support, and product marketing. Before joining Thermo Fisher Scientific, he worked as Analytical Development Scientist at MSD. Mauro holds a PhD in analytical chemistry from the University of Amsterdam.
</blockquote>
<blockquote>
Presenter: Dr. habil. Frank Steiner (Senior Manager Product Applications &amp;Scientific Advisor, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Frank Steiner is currently managing an applications laboratory and coordinating scientific collaborations in the HPLC organization of Thermo Fisher Scientific. He received his PhD degree in Chemistry in 1995 from the Saarland University in Saarbrücken, Germany working on development of stationary phases for IC. He then became a postdoctoral research fellow at the CEA, Saclay in France focusing on elementary and isotopic analysis by IC and IC-ICP/MS in 1996. Frank returned to Saarland University in 1997 to conduct research on electro-driven separation, LC purification and MS coupling technologies and became an assistant professor in 2003, after receiving the university teaching credentials (habilitation).
</blockquote>
<blockquote>
In 2005 Frank joined Dionex GmbH in Germering, Germany now a part of Thermo Fisher Scientific, as the manager for LC systems. Frank played a significant role in developing and launching the Vanquish UHPLC systems. He published over 30 publications in refereed journals and more than 10 text book chapters on HPLC method development and optimization.
</blockquote>
<blockquote>
Presenter: Dr. Jeff Op de Beeck (Staff Scientist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Jeff Op de Beeck is currently Staff Scientist at Thermo Fisher Scientific’s R&amp;D facility in Ghent where micro pillar array technology is developed and produced. His work under the supervision of Prof. Gert De Smet and Prof. Wim De Malsche formed the basis for the current micro Pillar Array Column, which is branded by Thermo Fisher Scientific as the µPAC™. He holds a master’s degree in Biomedical Sciences from the University of Antwerp and a Ph.D. in Chemical Engineering from the University of Brussels.
</blockquote>
<blockquote>
Presenter: Natalie Van Landuyt (Thermo Fisher Scientific)
</blockquote>
<blockquote>
Natalie Van Landuyt is currently Scientist at Thermo Fisher Scientific’s R&amp;D facility in Ghent where micropillar array technology is developed and produced. With expertise in biotechnology, she made contributions as an R&amp;D Developer at PharmaFluidics and Senior Developer Immuno Assays at MyCartis. Earlier, she demonstrated leadership as a lab manager and became experienced in nanoLC as senior research associate during her tenure at Pronota, a Protein Biomarker discovery company. Natalie has a degree in Industrial Engineering Biochemistry and Medical Laboratory Technology from KHBO – Oostende/Brugge, Belgium.
</blockquote>

Thermo Scientific: HPLC Reloaded Day 1 – Quantitative Excellence in Pharma & Biopharma

Quantitative Excellence in Pharma & Biopharma

Discover the ground-breaking technology that promises a whole new level of chromatographic performance in low-flow applications.

We will examine how small changes to your vials &amp; closures can lead to a big impact to your recovery rates and reproducibility in your workflow.
Let´s be realistic: you will never get 100% of your analyte out of your sample handling container but we can help to secure your valid sample and improve the accuracy of your results.
During this webinar, we will examine developments and tips to:
<ul>
<li>eliminate or at least reduce adsorption in an autosampler vial</li>
<li>reduce the risk of moving your analyte out of the target pks/pka value for reliable LC analysis</li>
<li>eliminate sample loss due to evaporation by poor seals</li>
</ul>
We hope you will leave this webinar with an understanding on how to identify small fixes to reduce or eliminate sample loss for significant improvements. The session will finish with a short Q&amp;A and include a live chat with an expert.
<blockquote>
Presenter: Dr. Detlev Lennartz
</blockquote>
<blockquote>
Dr. Detlev Lennartz brings almost 30 years of experience in chromatography consumables (HPLC columns, GC columns, SPE cartridges, TLC products, and vials and closures). Twenty-four of those years he has been within product management developing and improving consumables for today’s researcher. His customer sales and technical support experience allows him to understand what challenges researchers face. The last twelve years Detlev has been the Thermo Scientific sample handling (autosampler vials, closures and well plates) worldwide product manager. Together, with a team of specialists, focusing on developing and launching new and innovative sample handling products, he hopes to share this knowledge to drive better efficiencies and improve results for researchers.
</blockquote>

VWR: How to reduce your sample loss to significantly improve your results

How to reduce your sample loss to significantly improve your results

We will examine how small changes to your vials & closures can lead to a big impact to your recovery rates and reproducibility in your workflow.

How to reduce your sample loss to improve your results

In this webinar, we will walk you through the use of Zeno SWATH DIA on the ZenoTOF 7600 system for high-performance proteomics analysis, highlighting the following:
<ul>
<li>Maximizing nanoflow chromatographic separation performance using IonOpticks Aurora SX series columns
</li>
<li>Achieving high sensitivity for protein detection and quantitation on low column loads of a complex digest standard, approximating single-cell protein levels
</li>
<li>Demonstrating depth of proteome coverage and quantitative fidelity with mixtures of digests from 3 different organisms, with protein ratios between mixtures accurately quantified using a label-free quantitation (LFQ) strategy
</li>
</ul>
<blockquote>
Presenter: Patrick Pribil (SCIEX)
</blockquote>

SCIEX: Pushing the boundaries of depth-of-coverage for nanoflow proteomics using Zeno SWATH DIA and IonOpticks Aurora SX series columns