Analýza vysoce čistého titanu pomocí Agilent 9500 ICP-QQQ

<div><div><div><div><p><strong>Plynová chromatografie (GC) je účinná analytická technika používaná k separaci, identifikaci a kvantifikaci jednotlivých složek komplexních směsí. Přesná a spolehlivá separace je nezbytná pro kvalitativní i kvantitativní analýzu v celé řadě oblastí, například ve farmacii, při environmentálních analýzách, kontrole bezpečnosti potravin nebo v petrochemickém průmyslu.</strong></p><p>Plynová chromatografie poskytuje výsledky s vysokým rozlišením, a proto hraje významnou roli při kontrole kvality výrobků, monitorování znečišťujících látek v životním prostředí i ve vědeckém výzkumu. Znalost základních principů GC umožňuje tuto techniku správně a efektivně využívat, získávat přesnější výsledky a dále rozšiřovat možnosti jejího použití.</p><h3><span><strong>Proces a principy separace v GC</strong></span></h3><p>Základem separace v GC jsou rozdíly v těkavosti sloučenin a v jejich interakcích se stacionární fází během průchodu kolonou za pomoci inertního nosného plynu, který tvoří mobilní fázi. Rozdílné chování jednotlivých sloučenin při působení teploty a jejich odlišné interakce se stacionární fází vedou k rozdílným retenčním časům, což umožňuje jejich přesnou identifikaci a analýzu.</p><p>Vzorek se odpaří a zavede do proudu inertního nosného plynu, například helia nebo dusíku, který jej transportuje kolonou obsahující stacionární fázi. Při průchodu kolonou jednotlivé složky vzorku interagují se stacionární fází v různé míře v závislosti na své těkavosti a afinitě ke stacionární fázi. Sloučeniny se silnějšími interakcemi postupují kolonou pomaleji, zatímco sloučeniny se slabšími interakcemi jí procházejí rychleji. Tím dochází k jejich separaci podle fyzikálně-chemických vlastností, zejména bodu varu a polarity.</p><p>V průběhu analýzy sloučeniny eluují z kolony v různých časech a na chromatogramu vytvářejí samostatné píky. Každý pík odpovídá určité sloučenině, přičemž retenční čas lze využít k její identifikaci. Plocha píku pak souvisí s množstvím dané sloučeniny a umožňuje její přesnou kvantifikaci.</p><blockquote><p>Objevte širokou škálu <a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/techniques/gc"><strong>GC aplikací a metod</strong></a> používaných v různých odvětvích pro přesnou analýzu a separaci sloučenin.</p></blockquote><h3><span><strong>Jednotlivé kroky analýzy pomocí plynové chromatografie</strong></span></h3><p>Analýza pomocí GC zahrnuje nástřik a odpaření vzorku, separaci jeho složek v koloně na základě rozdílných interakcí se stacionární fází a následnou detekci ve formě samostatných píků. Získaná data se poté vyhodnocují za účelem přesné identifikace a kvantifikace jednotlivých sloučenin. Mezi hlavní kroky analýzy pomocí plynové chromatografie patří:</p><p><strong>Nástřik vzorku</strong><br>Proces plynové chromatografie začíná nástřikem vzorku, při kterém je do systému pomocí stříkačky zavedeno malé a přesně definované množství vzorku. Tento krok je nutné pečlivě kontrolovat, aby nedošlo k přetížení kolony a byla zajištěna přesná a účinná separace.</p><p>Jednotlivé součásti nástřikového systému, například dávkovací stříkačky, autosamplery a injektory, se volí podle konkrétních analytických požadavků. Techniky nástřiku, jako jsou split, splitless nebo on-column, umožňují přizpůsobit způsob zavedení vzorku jeho koncentraci, těkavosti a požadované citlivosti analýzy. Správná volba a konfigurace nástřikového systému jsou zásadní pro dosažení optimální separace, omezení ztrát vzorku a zvýšení přesnosti analýzy.</p><p><strong>Odpaření vzorku</strong><br>Po vstupu do vyhřívaného injektoru se vzorek odpaří a přejde do plynné fáze. Následně se smísí s nosným plynem, obvykle inertním plynem, jako je helium nebo dusík. Nosný plyn transportuje odpařený vzorek kolonou, napomáhá jeho rovnoměrnému průchodu systémem a zabraňuje kondenzaci nebo ztrátám vzorku během transportu.</p><p><strong>Separace</strong><br>Při průchodu GC kolonou jednotlivé složky odpařeného vzorku různě interagují se stacionární fází na vnitřním povrchu kolony. Míra těchto interakcí závisí především na těkavosti a polaritě jednotlivých sloučenin. Sloučeniny s vyšší afinitou ke stacionární fázi se pohybují pomaleji, zatímco látky se slabšími interakcemi procházejí kolonou rychleji. Tento rozdílný pohyb vede k rozdělení vzorku na jednotlivé složky a umožňuje jejich samostatnou analýzu.</p><p><strong>Detekce</strong><br>Po výstupu z kolony procházejí separované sloučeniny detektorem, který zaznamenává a měří jejich přítomnost. Mezi běžně používané detektory patří plamenově ionizační detektor (FID) a hmotnostní spektrometr (MS). Každá sloučenina při průchodu detektorem vytváří signál, který je zaznamenán jako pík na chromatogramu. Jednotlivé píky odpovídají konkrétním sloučeninám a doba, za kterou sloučenina dosáhne detektoru, tedy retenční čas, může sloužit k její identifikaci.</p><p><strong>Vyhodnocení dat</strong><br>Chromatogram zaznamenaný detektorem se vyhodnocuje za účelem identifikace a kvantifikace sloučenin přítomných ve vzorku. Retenční časy se porovnávají s hodnotami známých standardů, což umožňuje určit identitu jednotlivých sloučenin, zatímco plocha jednotlivých píků souvisí s jejich koncentrací.</p><p>Pokročilé metody zpracování dat tento proces dále rozšiřují využitím matematických algoritmů pro práci s rozsáhlými datovými soubory, rozpoznávání charakteristických vzorců, současnou analýzu více sloučenin a optimalizaci parametrů separace. Díky tomu lze dále zvyšovat přesnost a efektivitu analytického procesu.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/gas-chromatography"><strong>Prozkoumejte pokročilé techniky plynové chromatografie</strong></a>, které pomáhají zvýšit citlivost, zlepšit rozlišení a optimalizovat analytické postupy.</p></blockquote><h4><strong>Závěr</strong></h4><p>GC systém se skládá ze čtyř hlavních částí: <strong>injektoru</strong>, ve kterém je vzorek zaveden do systému a odpařen; <strong>nosného plynu</strong>, který transportuje odpařený vzorek kolonou umístěnou v termostatu; <strong>GC kolony</strong>, ve které dochází k separaci jednotlivých složek na základě jejich interakcí se stacionární fází; a <strong>detektoru</strong>, který identifikuje a kvantifikuje separované analyty po jejich výstupu z kolony. Společně tyto části umožňují přesnou separaci, detekci a analýzu těkavých látek v široké škále analytických aplikací.</p></div></div></div></div>

Základní součásti systému plynové chromatografie

<p><strong>Milí uživatelé chromatografických systémů,</strong></p><p>také zažíváte údiv nad tím, proč různé přístroje v laboratoři, byť od stejného výrobce, pracují pod různým SW? Nechcete ztrácet čas učením se různých softwarů? Potřebujete kompletně splnit požadavky regulované laboratoře pro všechny Vaše chromatografické a MS přístroje? Chcete jednoduše řešit bezpečnost a zálohy dat a updaty software?</p><p><strong>Pak je tu pro Vás nový OpenLab CDS 3.0! Umožní laboratořím sjednotit softwarové platformy, zefektivnit každodenní práci a zachovat přehled i kontrolu nad laboratorními daty.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Altium_International_Openlab_CDS_3_0_33d8295300.jpg" alt="Altium International: OpenLab CDS 3.0" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Altium_International_Openlab_CDS_3_0_33d8295300.jpg 245w," sizes="100vw" width="1549" height="436"></p><p>Software je navržen pro <strong>moderní farmaceutické a biofarmaceutické laboratoře </strong>a nabízí:</p><ul><li><strong>Sjednocenou softwarovou platformu pro různé typy přístrojů LC, LC/MS, GC, GC/MS, LC/HRMS i preparativní HPLC:</strong> řízení přístroje, sběr dat a jejich vyhodnocení</li><li><strong>Splnění všech regulatorních požadavků pro GMP prostředí:</strong> bezpečnost, zálohování a dohledatelnost dat, přehlednou správu uživatelských oprávnění a „audit trail“</li><li>Zachování plné funkcionality pro pokročilé zpracování dat včetně HRMS</li><li><strong>Multi-attribute-method (MAM) workflow</strong> pro biopharma laboratoře</li><li><strong>Automatizaci rutinních činností </strong>a méně manuální práce</li><li><strong>Vylepšené možnosti vyhodnocení dat: </strong>možnost vyhodnotit MS nebo UV/VIS spektrum „živě“ během analýzy, možnost řazení dle analytu, vyšší flexibilita práce s qualifier ions atd.</li><li><strong>Možnost ekonomicky výhodného rozšíření podle potřeb laboratoře:</strong> Architektura klient–server umožňuje systém postupně rozšiřovat a současně podporuje bezpečnou a centralizovanou správu dat a updaty softwaru.</li></ul><blockquote><h5><strong>Neváhejte nás kontaktovat!</strong></h5><p><strong>Jana Hepner</strong></p><ul><li><a href="mailto:jana.hepner@altium.net">jana.hepner@altium.net</a></li><li>+420 734 601 174</li></ul></blockquote>

Nová verze softwaru OpenLab CDS 3.0

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Video

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Je autorizovaným distributorem společnosti Agilent Technologies pro Českou republiku v oblastech chromatografie (GC, HPLC, UHPLC, kapilární elektroforéza) a hmotnostní spektrometrie (GC/MS, LC/MS, CE/MS), disolučních aparátů, molekulární (UV-Vis, UV-Vis-NIR, fluorescence, FTIR analyzátory a mikroskopy) a atomové spektroskopie (ICP-OES, ICP-MS, AAS), a v neposlední řadě také v oblasti molekulární biologie a genomiky (analýza nukleových kyselin a proteinů, microarray skenery a skla, PCR & RT-PCR, qPCR, řešení pro NGS, reagencie pro mutagenezi a klonování, sondy FISH a další).

Altium International

Společnost Phenomenex je celosvětovým technologickým lídrem, který se zabývá vývojem nových řešení v oblasti analytické chemie, jež řeší požadavky analytiků na separace a purifikace v průmyslových, vládních a akademických laboratořích.

Phenomenex

Agilent Technologies

Thermo Fisher Scientific

SelectScience

SciY/Mestrelab Research

Waters Corporation

<p><strong>Choosing the right internal standard is critical to achieving accurate, reliable ICP‑OES results—but knowing how and when to apply one isn’t always straightforward. In this webinar, we’ll review the fundamental principles of internal standardization in ICP‑OES and provide practical guidance on selecting the most appropriate internal standards for different elements, sample types, and analytical challenges. You’ll learn how internal standards help correct for signal drift, matrix effects, and sample introduction variability, as well as common pitfalls to avoid. Through real‑world examples, we’ll demonstrate how proper internal standard selection and implementation can improve data quality, confidence, and consistency across both routine and more challenging analyses.</strong></p><blockquote><p><strong>Presenter:</strong> Ana García González (Atomic Spectroscopy Application Scientist, Agilent Technologies)</p><p>Ana Garcia is the Atomic Spectroscopy Application Scientist at Agilent Technologies. Ana has a broad background in atomic spectroscopy technologies, including international experience developing and validating analytical spectroscopy methods for the geochemical industry. She has also published in the fields of molecular spectroscopy and chemometrics. Ana holds a MSc in plant Biotechnology at CINVESTAV, México, and a Bachelor of Science in Biotechnology Engineering.</p></blockquote>

Agilent Technologies: Learn to Select and Apply the Proper Internal Standard in ICP-OES

Learn to Select and Apply the Proper Internal Standard in ICP-OES

Learn how to select and apply internal standards in ICP-OES. Correct for matrix effects, signal drift, and sample introduction variability effectively

Selecting & Applying Internal Standards in ICP-OES

<p><strong>Laboratories are under growing pressure to handle increasing volumes of samples and data while operating under tighter regulatory inspection, all without compromising turnaround times or traceability. In this context, many organizations attempt to extend existing workflows and legacy tools, which can introduce inefficiencies, increase manual effort, and create compliance risks. At the same time, it is not always clear which digital solutions are best suited to address these challenges.</strong></p><p>This presentation illustrates how modern digital laboratory environments streamline routine activities by minimizing manual tasks and embedding compliance directly into everyday workflows. Drawing on a real-world use case, we show how automated capture of data from multiple sample measurements at the point of execution enables a continuous, sample-centric workflow.</p><p>By removing manual interventions and paper-based processes, laboratories can improve efficiency and visibility, support faster and more reliable decision-making while remaining responsive to evolving customer demands.</p><h4><strong>Learning Points</strong></h4><ul><li>The role of different systems (LIMS, SDMS, ELN) within the digital lab landscape and how they differ from each other's</li><li>How WebLab manages laboratory operations from a sample perspective, enabling you to track every sample, stage, and next action across workflows</li><li>How automated data capture from connected instruments helps reduce errors, lower contamination risks, and accelerate sample processing</li><li>You will see, through a real-life example, how integrated digital workflows improve data quality, accelerate reporting, and increase operational efficiency</li></ul><h4><strong>Who should attend</strong></h4><p>Professionals working in small to mid‑sized laboratories, including:</p><ul><li>Directors and Managers of Analytical, QC, or Contract Labs</li><li>Lab Operations and QA/QC Leaders</li><li>Digitalization and IT at organizations transitioning from paper, Excel, or legacy systems to LIMS</li></ul><blockquote><p><strong>Presenter:</strong> Peter Bellstedt, PhD (Director of Business Development and Product Manager at SciY)</p><p>Peter studied Biochemistry at the University of Jena before completing a PhD on the structural characterization of a DNA repair protein using solution and solid-state NMR. He was then appointed as the head of the NMR Spectroscopy Platform in Jena, Germany, where he pioneered the implementation of modern, highly efficient data-driven workflows. After five years, he moved to the University of Zurich, Switzerland, as a principal investigator, where his lab focused on structure-based drug discovery. This year, he brought his wealth of experience to the LOGS by SciY team, focusing on efficient workflow solutions for research labs and facilities on a global scale.</p></blockquote>

SciY: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision

From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision

Transition from paper to a paperless lab. Discover how WebLab, LIMS, and automated data capture streamline sample tracking and boost compliance

Paperless Labs & Sample Tracking: Digital LIMS Workflows

<h4><strong>How about a 30 minute coffee break along with a bite of Empower?</strong></h4><h5><strong>Here you go!</strong></h5><p><strong>Faster Root Cause Analysis with Next-Generation LC and Empower™ Software</strong></p><p>Discover how next-generation LC systems connected to Empower software automatically capture critical system and method data, enabling faster troubleshooting and root cause analysis. Learn how to quickly identify the causes of peak tailing, reduced resolution, lower sensitivity, and other routine deviations while improving laboratory efficiency and confidence in your results.</p><h5><strong>Key takeaways:</strong></h5><ul><li>Automated data capture with connected LC systems and Empower</li><li>Faster identification of chromatographic issues</li><li>Improved troubleshooting efficiency and reduced downtime</li><li>Enhanced data integrity and compliance support</li></ul><p><strong>Prepare a coffee and attend!</strong></p><blockquote><p><strong>Speaker:</strong> Ralf Schröder (Informatics Market Development Manager)</p><p><strong>Speaker:</strong> Andrea Gheduzzi (Principal LC Market Development Manager)</p></blockquote>

Informatics series #34 Ready for Self-Documenting Chromatography?

Discover self-documenting LC with Waters Empower. Learn how connected LC systems automate root cause analysis and reduce troubleshooting downtime

Informatics series #34 Self-Documenting LC & Empower

<p><strong>Modern pixelated detectors can generate tens to hundreds of gigabytes of data during a single 4D-STEM scan, creating practical challenges for acquisition, processing, and interpretation.</strong></p><p><strong>In this SelectScience® webinar, Arno Annys will demonstrate how event-driven electron detection can provide a more efficient representation of electron signals and help streamline the workflow from experiment to scientific insight.</strong></p><p>Using application-based examples, the session will explore how event-driven acquisition, adaptive scanning strategies, and real-time ptychographic reconstruction can reduce the 4D-STEM data burden, support low-dose experiments, and provide immediate feedback during acquisition.</p><p>Attendees will learn how these approaches can make advanced 4D-STEM experiments more scalable, responsive, and accessible for routine use.</p><h5><strong>Certificate of attendance</strong></h5><ul><li>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.</li><li>If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.</li></ul><h5><strong>Webinar details</strong></h5><ul><li><strong>Cost:</strong> Free to attend</li><li><strong>Location: </strong>Online</li><li><strong>Duration: </strong>60 minutes</li></ul><p><i>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available</i></p><h5><strong>Who should attend?</strong></h5><p>This event is perfect for individuals working in:</p><ul><li>Electron microscopists, materials scientists, physicists and instrument scientists working with STEM, 4D-STEM, ptychography, diffraction imaging or electron energy-loss spectroscopy</li><li>Researchers investigating beam-sensitive materials, developers of microscopy acquisition and processing workflows, facility managers, and scientists considering the adoption of event-driven direct electron detection</li></ul><h5><strong>What will this webinar cover?</strong></h5><p><strong>Key learning objectives:</strong></p><ul><li>Understand how event-driven detection changes the way 4D-STEM data are acquired, represented and processed.</li><li>Discover how adaptive scanning strategies can improve experimental flexibility and focus acquisition on the most scientifically valuable regions.</li><li>Learn how event-by-event ptychographic reconstruction can provide rapid feedback during an experiment.</li><li>See practical examples of how event-driven workflows can reduce data volumes and support low-dose and beam-sensitive applications.</li></ul><blockquote><p><span><strong>Speaker: </strong></span>Arno Annys (PhD Researcher, Electron Microscopy for Materials Science, University of Antwerp)</p><p>Arno Annys is a PhD researcher in the group of Professor Jo Verbeeck within the Electron Microscopy for Materials Science department at the University of Antwerp. His research focuses on the development of advanced 4D-STEM and electron energy-loss spectroscopy techniques. He is particularly interested in how event-driven direct electron detectors can enable new acquisition strategies, including adaptive scanning, efficient event-based data processing and real-time electron ptychography.</p></blockquote><blockquote><p><strong>Moderator: </strong>Todd Beanlands (Science Editor, SelectScience)</p></blockquote>

Select Science: Managing 4D-STEM data with smarter acquisition

Managing 4D-STEM data with smarter acquisition

Reduce 4D-STEM data burden with event-driven electron detection, adaptive scanning, and real-time ptychography in this Quantum Detectors webinar

4D-STEM Data Reduction & Event-Driven Detection

<p><strong>Wastewater surveillance has become an increasingly valuable approach for monitoring antimicrobial resistance (AMR) within a One Health framework. &nbsp;However, comprehensive characterization of antimicrobial resistance genes (ARGs) in complex environmental samples remains challenging using conventional methodologies alone.</strong></p><p>Join Helena Torrell, PhD, and Douglas Hurd, PhD, for a webinar discussing the challenges of antimicrobial resistance (AMR) surveillance in complex environmental samples and the growing need for sensitive, targeted genomic approaches. &nbsp;Douglas will provide an overview of Agilent’s SureSelect target enrichment technology prior to Next Generation Sequencing and its role in enhancing the detection of low-abundance gene sequences, before introducing guest speaker Helena Torrell, PhD. Helena will share her team’s innovative application of targeted hybridization capture for wastewater-based AMR surveillance.</p><p>This presentation will introduce a targeted hybridization capture strategy we developed to enhance the detection and characterization of known ARGs in environmental samples. &nbsp;Using hospital wastewater as a case study, the presentation will discuss the outstanding performance of our targeted enrichment approach for AMR surveillance, demonstrating its potential advantages and comparing its performance with untargeted shotgun metagenomic sequencing. The session will also address the opportunities and current limitations of targeted capture technologies for environmental resistome monitoring and their potential role in future surveillance programs.</p><h4><strong>Learning Objectives:</strong></h4><ol style="list-style-type:decimal;"><li>Learn how targeted capture improves ARG detection and environmental samples.</li><li>Compare targeted enrichment with shotgun metagenomic sequencing for AMR surveillance.</li><li>Explore the benefits and limitations of targeted capture for resistome monitoring</li></ol><blockquote><p><strong>Presenter:</strong> &nbsp;Helena Torrell Galceran, PhD ( Head of the Genomics Platform, Omic Sciences Unit, Eurecat Technology Center, Barcelona, Spain)</p><p>Helena Torrell, PhD in Biomedicine, is the Head of the Genomics Platform within the Omic Sciences Unit at Eurecat Technology Center (Barcelona, Spain). &nbsp;She specializes in microbial genomics, metagenomics, and next-generation sequencing technologies, with a particular focus on developing genomic tools for infectious disease research, antimicrobial resistance surveillance, and environmental monitoring. &nbsp;She leads the implementation of advanced sequencing technologies and supports multidisciplinary research projects aimed at translating genomic into practical applications for public health, clinical research, and the One Health framework.&nbsp;</p></blockquote><blockquote><p><strong>Presenter: &nbsp;</strong>Douglas Hurd, PhD (Field Application Scientist, Agilent)</p><p>Dr. Douglas Hurd has worked in Customer support and R&amp;D roles for many years within the Biotechnology industry. &nbsp;He currently supports Agilent’s genomics instrumentation and reagents, as well as the Automated electrophoresis instruments such as the TapeStation, Fragment Analyzer, and ProteoAnalyzer.</p></blockquote>

Agilent: Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples

Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples

Learn how Agilent SureSelect targeted hybridization capture enhances AMR surveillance and low-abundance ARG detection in complex wastewater samples

Targeted Capture for AMR Surveillance in Wastewater

<p><strong>Understanding the tissue microenvironment in tumour samples is an important factor for predicting response to different treatment regimens. Highly multiplexed imaging of tenfolds of protein markers can help to define this complex biology. However, these assays are costly and not always easy to scale for larger translational studies that are often needed to translate findings to clinical evidence.&nbsp;</strong></p><p>In this webinar, we demonstrate how we move from a highly multiplexed imaging platform used in a discovery phase to identify a marker for response prediction to immunotherapy at the translational phase. This transition was possible with the use of the Invitrogen™ EVOS™ S1000 Spatial Imaging System in combination with the Invitrogen™ Aluora™ Spatial Amplification Kits and a panel of 6 markers. By focusing on the most relevant targets from the discovery panel, the cost per sample is reduced to about 25 % of the initial assay, thereby resulting in a more affordable option for larger translational cohort studies. In addition, we show how relevant protein markers can be combined with in situ proximity Ligation Assay (is PLA) to simultaneously look at protein interactions, in this case demonstrated for PD-1/PD-L1. In summary, this workflow enables scalable, cost-effective spatial biology approaches that bridge discovery and clinical translation.&nbsp;</p><h4><strong>Learning Objectives:</strong></h4><ul><li>Learn how to transition from discovery to translational proteomic imaging assays&nbsp;</li><li>Understand how spectral imaging with the EVOS S1000 Spatial Imaging System can be used for hypothesis-driven research</li><li>Explore the use of spatial amplification reagents for exploring the tissue microenvironment</li></ul><blockquote><p><strong>Presenter: </strong>Charlotte Stadler, PhD (Co-director of Spatial Biology and Head of the National Spatial Proteomics facility at Science for Life Laboratory)</p><p>Charlotte Stadler is the co-director of the Spatial Biology platform and Head of the National Spatial Proteomics facility at Science for Life Laboratory. She is also a Principal Investigator at the Royal Institute of Technology. She received her Ph.D. in 2012 within the framework of the Human Protein Atlas (HPA) project, with Prof. Emma Lundberg and Prof. Mathias Uhlén as her supervisors. During her PhD she established many of the protocols and pipelines for image based subcellular protein profiling that are used in the Human Protein Cell Atlas. Today, her main focus is to develop and implement services and technologies within spatial biology that can be used projects ranging from discovery to translational and clinical research. In her role she works with many companies in the spatial omics field including Thermo Fisher Scientific. Her internal research projects focus on the implementation and adaptation of multiplexed imaging solutions into clinical practice but also on integrating different omics types for a more complete molecular understanding of the tissue sample biology.&nbsp;</p></blockquote><blockquote><p><strong>Presenter: </strong>Adyary Fallarero, PhD, MBA (Sr. Manager, Thermo Fisher Scientific, Faculty of Pharmacy, University of Helsinki, Finland)</p><p>Dr. Fallarero earned PhD in Biochemistry from the University of Havana, Cuba and a Master in International Business Management (MBA) from the Tampere University of Applied Sciences, in Finland.</p><p>During her more than 10 years of academic career, she published over 75 peer-reviewed publications, co-authored over 10 patents, and was awarded multiple grants to lead research programs focused on early drug discovery of anti-biofilms. In 2018, she received the prestigious Oskar Öflund’s Foundation Grand Prize, for her contributions to the development of the field of bacterial biofilms in Finland.</p><p>She joined Thermo Fisher Scientific in 2016 to work on cell analysis instrumentation, gaining significant expertise in new product development and product management. Since 2021, she has been responsible for new product introductions, portfolio management and commercial enablement of cell and tissue imaging systems.</p></blockquote>

Thermo Fisher Scientific: Spatial Proteomics for Translational Research

Spatial Proteomics for Translational Research

Scale spatial proteomics from discovery to translation. Learn how Thermo Fisher's EVOS S1000 & Aluora kits reduce sample costs for tumor imaging

Spatial Proteomics in Translation: EVOS S1000 Imaging

<p><strong>This webinar provides a foundational overview of LC method optimization. The session will focus on parameters that are significant for method optimization, including column dimensions, sample loading, particle morphologies, silica specifications, and stationary phase selectivities. Attendees will gain insight into how to use method development tools for scalability, throughput, and reproducibility for their LC methods.</strong></p><h4><strong>Key Learning Points</strong></h4><ul><li>Understand your column, from hardware design through stationary phase.</li><li>Learn how to choose the right particle morphology to match your analytical objectives.</li><li>Master sample load scaling for consistent, reliable results.</li><li>Apply LC method scaling parameters to maximize throughput while maintaining reproducibility.</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Any scientists and professionals working with liquid chromatography who want to learn about LC method optimisation during scaling for high throughput and preparative applications.</li></ul><h4><strong>One webinar, two viewing options</strong></h4><p>We know you're busy, select a viewing session that works best for you.</p><h5><strong>Viewing Options</strong></h5><p><strong>Session 1: Tuesday, September 1, 2026</strong></p><ul><li>Los Angeles: 10:00 AM PT&nbsp;</li><li>New York: 1:00 PM EST</li><li>Mexico City: 12:00 PM CDT</li></ul><p><strong>Session 2:Wednesday, September 2, 2026</strong></p><ul><li>London: 9:00 AM BST&nbsp;</li><li>Berlin: 10:00 AM CEST&nbsp;</li><li>Mumbai: 1:30 PM IST</li></ul><blockquote><p><strong>Speaker:</strong> Namrata Saxena (Technical Manager, Phenomenex)</p><p>&nbsp;Namrata Saxena is the Technical Manager for the Asia-Pacific region at Phenomenex and is part of the global technical team, she provides expert support for a wide range of chromatographic challenges particularly in the characterization of biotherapeutics and emerging cell and gene therapy modalities. Her role includes delivering technical training, hosting seminars and webinars, and contributing to scientific content development. Prior to joining Phenomenex, Namrata worked as a Product Specialist at Bischoff Chromatography GmbH in Germany where she gained extensive experience in stationary phase chemistry, column manufacturing and method development domains.&nbsp;</p></blockquote>

Phenomenex: Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility

Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility

Optimize and scale LC methods with confidence. Learn how column dimensions, particle morphology, and sample load impact throughput and reproducibility

LC Method Optimization: Scaling for High-Throughput Labs

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Top-down mass spectrometry enables a proteoform-first approach by keeping the protein molecule intact, combining intact mass information with intact-ion fragmentation to support confident characterization of sequences, modifications, variants, and proteoforms. In this webinar, you will see how Thermo Scientific Proteoform Studio brings acquisition, analysis, visualization, and reporting together in a streamlined workflow for intact mass and top-down applications.</strong></p><h5><strong>By attending this webinar, you will learn how to:</strong></h5><ul><li><strong>Understand how top-down MS supports proteoform-first characterization:</strong> See how intact mass and intact-ion fragmentation can be used to characterize proteoforms, modifications, variants, and sequence coverage.</li><li><strong>See how Proteoform Studio simplifies acquisition, analysis, and reporting: </strong>Learn how integrated instrument control, interactive deconvolution, targeted top-down method creation, database management, result review, and automated reports can reduce workflow complexity.</li><li><strong>Learn how Direct Mass Technology™ and automated workflows can improve data quality and productivity: </strong>Explore how Direct Mass Technology™, automated charge assignment, data aggregation, and proteoform tracks can help improve sequence coverage, simplify comparison, and support deeper characterization.</li></ul><h5><strong>Topics covered:</strong></h5><ul><li>Why top-down mass spectrometry matters</li><li>Proteoform Studio for intact protein characterization</li><li>Interactive deconvolution and walk-up analysis</li><li>Mixed and sliding-window deconvolution</li><li>Targeted top-down method creation</li><li>Direct Mass Technology™ workflows</li><li>Proteoform tracks and data aggregation</li><li>Automated reporting</li></ul><p>You will leave with a practical understanding of how Proteoform Studio can help streamline intact mass and top-down workflows for applications such as biotherapeutic characterization, antibody analysis, covalent binder localization, native MS, and deep proteoform sequencing.</p><h5><strong>This webinar is designed for scientists working in:</strong></h5><ul><li>Intact protein analysis</li><li>Top-down proteomics</li><li>Native MS</li><li>Biotherapeutic characterization</li><li>Proteoform analysis</li><li>Protein complex or antibody characterization</li><li>Mass spectrometry core facilities supporting intact protein workflows</li></ul><p>If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.</p><blockquote><p><strong>Presenter: </strong>Jacob McCabe (Product Manager, Proteinaceous- Thermo Fisher Scientific)</p><p>Jacob McCabe, Ph.D., is a life-science innovator specializing in mass spectrometry, high-throughput automation, and software engineering who currently serves as a Product Manager at Thermo Fisher Scientific following the acquisition of Proteinaceous in March 2026. With a focus on translating complex research into scalable, user-centric digital solutions, he leads cross-functional teams to bridge laboratory instrumentation with automated workflows</p></blockquote></div></div></div>

Thermo Fisher Scientific: ASMS 2025 Workshops

Proteoform Studio software, top down made simple

Simplify top-down MS with Thermo Scientific Proteoform Studio. Learn how automated deconvolution and Direct Mass Technology™ analyze intact proteoforms

Proteoform Studio: Top-Down MS & Intact Protein Analysis

<p><strong>Achieving comprehensive antibody-drug conjugate (ADC) characterization no longer requires complex multi-step workflows. Advances in native LC-MS are creating new opportunities to simplify ADC analysis while maintaining the depth of information needed to support development decisions.</strong></p><p>In this SelectScience® TechTalk, Roxana Eggleston-Rangel, Senior Applications Scientist at Phenomenex, will showcase how Biozen® Native RP-1 and RP-5 columns enable direct drug-to-antibody ratio (DAR) analysis through a streamlined, MS-compatible native reverse-phase liquid chromatography-mass spectrometry (RP-LC-MS) workflow.</p><p>Learn how this approach supports DAR determination, proteoform characterization, and positional isomer resolution without fraction collection or buffer exchange while maintaining native conditions.</p><p>Using case studies featuring the approved ADC therapies Enhertu®, Padcev®, Polivy®, and Adcetris®, Eggleston-Rangel will demonstrate how this workflow can be applied across a range of ADC modalities and payload chemistries. In just 20 minutes, discover how the same approach can support both high-resolution mass spectrometry and routine UV-based DAR monitoring, bringing greater efficiency and confidence to ADC characterization.</p><h5><strong>Certificate of attendance</strong></h5><p>If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.</p><h5><strong>TechTalk details</strong></h5><ul><li>Cost: Free to attend</li><li>Location: Online</li><li>Duration: 20 minutes</li></ul><p>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.</p><h5><strong>Who should attend?</strong></h5><p><strong>This event is perfect for:</strong></p><ul><li>Pharmaceutical and biopharmaceutical characterization scientists</li><li>Analytical development managers and directors overseeing LC-MS workflows</li><li>Researchers developing methods for ADC characterization, drug-to-antibody ratio (DAR) analysis, and isomer identification</li></ul><h5><strong>What will this webinar cover?</strong></h5><ul><li>How native RP chromatography can be used for streamlined ADC DAR characterization and intact mass analysis.</li><li>Best practices for selecting Biozen® Native RP columns based on ADC properties and analytical goals.</li><li>How a single workflow can provide DAR determination, proteoform characterization, and positional isomer information.</li><li>Real-world examples demonstrating how native RP-LC-MS can improve efficiency while reducing sample preparation complexity.</li></ul><h5><strong>Join the TechTalk to get answers to these questions:</strong></h5><ul><li>How can native RP-LC-MS simplify comprehensive ADC characterization workflows?</li><li>How do Biozen® Native RP-1 and RP-5 columns enable direct intact ADC analysis?</li><li>How is drug-to-antibody ratio (DAR) accurately determined under native conditions?</li><li>How can native RP-LC-MS resolve proteoforms and positional isomers in ADCs?</li><li>What insights were gained from case studies on Enhertu®, Padcev®, Polivy®, and Adcetris®?</li></ul><blockquote><p><strong>Speaker:</strong> Roxana Eggleston-Rangel (Senior Application Scientist, Phenomenex)</p><p>Roxana Eggleston-Rangel is a Senior Applications Scientist specializing in biopharmaceutical characterization workflows, with expertise in LC-MS, native chromatography, antibody-drug conjugates (ADCs), monoclonal antibodies, and protein biotherapeutics. She develops and evaluates analytical methods for critical quality attributes, including drug-to-antibody ratio (DAR), oxidation, isomerization, glycation, and fragmentation. Her work focuses on advancing innovative chromatographic and mass spectrometry solutions, generating application data, technical publications, and scientific content that help researchers improve characterization of complex biologics and next-generation therapeutics.</p></blockquote>

Phenomenex: TechTalk - ADC characterization in one native LC-MS workflow

ADC characterization in one native LC-MS workflow

Simplify ADC characterization with Phenomenex Biozen® Native RP columns. Learn direct DAR determination and proteoform profiling in one LC-MS workflow

Native LC-MS ADC Characterization: Phenomenex Biozen Columns

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join our experts for an in-depth look at the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid Mass Spectrometer—a next-generation HRAM platform designed to help laboratories confidently tackle today's analytical challenges while remaining ready for tomorrow's discoveries.</strong></p><p>Whether you're working in metabolomics, drug metabolism, environmental and food safety research, proteomics, or bioanalysis, the Orbitrap Excedion MS delivers the sensitivity, dynamic range, and robustness needed to detect more low-abundance compounds, improve confidence in your results, and maximize productivity. Learn how Full Scan Enhanced Dynamic Range (eDR) technology enables deeper sample coverage by revealing low-level analytes that conventional full-scan methods may miss, while maintaining outstanding quantitative performance.</p><p>This session will also explore how the Orbitrap Excedion platform is purpose-built for long-term value. With in-lab upgrade paths to the Orbitrap Excedion Pro MS, laboratories can expand capabilities as research needs evolve—protecting their investment without replacing their instrument. You'll also discover how a redesigned front-end, robust ion source, and simplified maintenance contribute to reliable, reproducible performance and greater uptime for busy laboratories.</p><p>Bring your questions and hear directly from our product experts about the innovations that are helping researchers generate more confident results today while preparing for the analytical challenges of tomorrow.</p><h4><strong>Who should attend?</strong></h4><ul><li>Scientists and laboratory managers seeking greater sensitivity, dynamic range, and confidence in HRAM mass spectrometry workflows.</li><li>Researchers working in metabolomics, DMPK, environmental and food safety, proteomics, bioanalysis, or other complex small-molecule applications.</li><li>Existing Orbitrap users and laboratories planning future instrument investments who want to understand the benefits of a scalable, upgradeable platform.</li></ul><h4><strong>What you can expect to learn</strong></h4><ul><li>How Full Scan Enhanced Dynamic Range (eDR) technology improves detection of low-abundance compounds and expands analytical coverage in complex samples.</li><li>How the Orbitrap Excedion MS delivers robust, reproducible performance with improved uptime, simplified operation, and reliable quantitative results.</li><li>How the platform's in-lab upgrade path enables your laboratory to add new capabilities as your research evolves, protecting your investment and future-proofing your workflows.</li></ul><blockquote><p><strong>Presenter: </strong>Maciej Bromirski (Sr. Product Marketing Manager, Thermo Fisher Scientific)</p><p>Maciej Bromirski has over 25 years of experience in mass spectrometry starting as an undergraduate student with late Prof. Ken Standing at the Physics Department at University of Manitoba in Winnipeg, Canada. Upon completion of his graduate studies on IR &amp; UV vacuum MALDI Q-TOF prototype MS with first oral presentation at ASMS and publications starting in 1999, Maciej undertook various roles and responsibilities with different Mass Spectrometry vendors. Since 2010 to present-day, Maciej has been fully dedicated to new product introductions and marketing developments of Q Exactive series, Orbitrap Exploris and more recently Orbitrap Excedion series MS with Thermo Fisher Scientific.</p><p><strong>Presenter: </strong>Claire Dauly (Senior Product Manager, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Explore the Orbitrap Excedion MS, featuring enhanced dynamic range, robust HRAM performance and an upgrade path to the Excedion Pro platform.

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