Út, 17.11.2026 17:30 CET
Webinář ukáže využití Orbitrap Excedion HRAM MS a technologie eDR pro identifikaci nečistot, studium degradace a strukturní charakterizaci syntetických peptidů.Přejít na webinář
Advancing Impurity and Degradation Product Identification in Synthetic Peptides
Thermo Fisher Scientific: The Groundbreakers Series: Pushing Boundaries
As therapeutic peptides continue to expand across the drug development pipeline, their structural complexity creates new challenges for identifying impurities, understanding degradation pathways, and assessing product stability. Join Jessica Hoskins for a practical look at how high-resolution mass spectrometry can help characterize degradation products in synthetic peptides and support pharmaceutical development.
Using a synthetic peptide subjected to oxidative and base-stress conditions, Jessica will share her experience evaluating the Thermo Scientific™ Orbitrap™ Excedion™ Hybrid Mass Spectrometer for impurity and degradation product identification. See how improved sensitivity can help reveal low-level and chromatographically unresolved impurities, making it easier to correlate mass spectrometry signals with chromatographic peaks and identify chemical transformations.
The session will also explore how improved data quality can support automated impurity identification and how Full Scan Enhanced Dynamic Range (eDR) technology can reveal additional peptide charge states.
Who should attend?
Scientists in pharmaceutical development, analytical R&D, predictive stability, structure elucidation, and researchers developing or characterizing synthetic peptides and other complex therapeutic modalities.
What you can expect to learn
- How HRAM MS can address synthetic peptide impurity and degradation product identification
- How improved sensitivity can reveal low-level and chromatographically unresolved peptide impurities
- How eDR technology can provide additional information for peptide characterization and structure elucidation
Presenter: Jessica Hoskins, PhD (Principal Research Scientist, Small Molecule Analytical R&D, AbbVie)
Jessica Hoskins is a Principal Research Scientist in Small Molecule Analytical R&D at AbbVie, focusing on Predictive Stability and Structure Elucidation. She earned her PhD in Organic Chemistry from Tulane University and later transitioned from synthesis to analytical chemistry and mass spectrometry.
Moderator: Breana Murphy (Regional Marketing Manager LSMS-North America, Thermo Fisher Scientific)
