Mitigating Analyte Interactions with Metal Surfaces in HPLC: Modern Inert Hardware Technologies

Reducing Metal-Analyte Interactions in HPLC

Interactions of analytes with metal surfaces in HPLC instruments and columns can cause a range of problems, including peak tailing, low peak areas and poor reproducibility. These effects can be mitigated using a surface modification technology in which an inert barrier based on an ethylene-bridged siloxane chemistry is applied to the metal components in HPLC instruments and columns. This technology has been demonstrated to give reduced tailing, higher peak areas and lower injection-to-injection variability for metal-adsorptive analytes such as those containing phosphate and/or carboxylate groups. Recent developments in inert columns for applications in pharmaceutical analysis and metabolomics will be discussed.

Join this webinar to learn more about:

• The causes and effects of analyte interactions with metal surfaces in HPLC columns and systems
• The analyte types that are susceptible to these interactions
• The separation conditions that influence the severity of these interactions
• The benefits of inert HPLC columns and systems
• How inert HPLC technologies can improve peak shape, enhance recovery of challenging analytes, and increase method robustness and reproducibility

Who should attend

This webinar is designed for scientists and managers working with HPLC in pharmaceutical and metabolomics applications who want to understand and mitigate analyte-metal interactions to achieve more reliable and reproducible results.

Don't miss it!

Speaker: Tom Walter (Corporate Fellow, Consumables and Lab Automation, Waters Corporation)

Thomas H. Walter is a Corporate Fellow in the Consumables and Lab Automation Division of Waters Corporation.

He is a coinventor of hybrid organic/inorganic particle technology with 15 issued US patents. He has authored sixty articles, white papers and technical notes and delivered a number of presentations at leading scientific conferences.

He is a member of the Jim Waters Society and the 2023 recipient of the Uwe. D. Neue Award in Separation Science.