Reducing biologic QC release risk with multi-angle light scattering

As multi-angle light scattering (MALS) becomes increasingly adopted in biopharmaceutical quality control, many laboratories are looking for ways to translate absolute molecular measurements into confident lot release decisions. Traditional size-exclusion chromatography (SEC) methods often rely on relative measurements, manual calculations, and analyst interpretation, making it difficult to fully assess aggregation, recovery, and molecular weight distribution. These risks can remain hidden until method transfer, regulatory review, or routine QC testing reveals unexpected variability.

In this SelectScience® webinar, Dr. Colette Quinn and Neil Lander from Waters, will discuss how integrating QC-ready MALS into an Empower™ workflow enables labs to quantify and manage release risk. Drawing on expertise in biologics characterization, multi-angle light scattering (MALS), laboratory informatics, and chromatography data systems, they will explore how standardized calculations transform raw MALS data into objective, reviewable metrics that reduce analyst-dependent interpretation and support more confident, defensible lot release decisions.

Register today to gain practical insights into managing release risk for proteins, peptides, biologics, and other complex modalities where aggregation and molecular heterogeneity can affect product quality. You will also discover how to bring MALS into routine QC testing, how to automate critical molecular measurements, and how to build the consistency, traceability, and confidence needed to support robust lot release decisions.

Certificate of attendance

If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

If you view the on-demand webinar, you can request a certificate of attendance by emailing [email protected].

Webinar details

• Cost: Free to attend
• Location: Online
• Duration: 60 minutes

Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.

Who should attend?

This event is perfect for:

• QC managers and directors responsible for release testing   
• MSAT and method transfer teams moving methods into QC
• Analytical development scientists supporting late stage programs
• Regulatory affairs and compliance professionals focused on audit readiness
• Organizations working with proteins, peptides, biologics, or complex modalities where aggregation and heterogeneity impact release decisions

What will this webinar cover?

• How to transition MALS from characterization to routine QC testing
• How to automate critical molecular metrics tied to release specifications
• How to improve consistency, traceability, and confidence in release decisions

Join the webinar to get answers to these questions:

• How can MALS transition from characterization to routine QC testing?
• How can critical molecular metrics tied to release specifications be automated?
• How do standardized MALS calculations reduce analyst-dependent interpretation?
• How can labs improve consistency and traceability in lot release decisions?
• How can aggregation, recovery, and molecular weight distribution be assessed confidently?

Presenter: Dr. Colette Quinn (Sr. Director and Interim Lab Analytics Portfolio Owner, Waters Corporation)

Dr. Colette Quinn holds a doctorate in chemistry from Dartmouth College, where she specialized in biophysical chemistry and thermodynamics. Her career spans applications science, microcalorimetry product management, biopharmaceutical business development, and strategic marketing. She has extensive experience in analytical technologies for biologics, including light scattering, mass spectrometry, and physicochemical characterization, and she has contributed to numerous scientific presentations and publications.

Presenter: Neil Lander (Senior Principal Product Manager, Waters Corporation)

Neil Lander is Senior Principal Product Manager at Waters Corporation, focusing on informatics solutions. He has worked at Waters since 1994, holding roles in technical support, technical training, and customer education. He provides internal support for the Empower Chromatography Data System and helps develop laboratory software solutions that support organizations in achieving their scientific and operational objectives. Before joining Waters, he worked as an analytical chemist in the cosmetics and specialty chemicals industries.

Presenter: Olivia Long (Editorial Team, SelectScience)

Olivia Long is a science editor specializing in pharmaceutical and applied science. She has a BSc in Pharmacology, and an MSc in Neuroscience, where she investigated neuro‑oncology drug‑resistance pathways using patient‑derived cell models. Her laboratory experience spans R&D hygiene testing, controlled‑environment sample production, and protocol development, giving her a broad understanding of analytical workflows and the scientific principles underpinning biopharma QC.