Tackling Bispecific Antibody Purification: A Polishing Case Study

Bispecific antibodies can present purification challenges that push beyond established platform processes. When molecules “misbehave,” downstream process development scientists need practical strategies for identifying suitable chromatography resins, conditions, and operating windows.

Join this data-driven presentation to explore process development resin screening for bispecific antibody purification.

See how product-related impurity profiles and high-throughput screening of resins across various modalities (ion exchange, hydrophobic interaction, and mixed-mode cation exchange) can help guide resin selection and identify conditions that balance yield and purity.

Attend this webinar to:

• Discover how bispecific impurity profiles can guide resin selection
• Learn a practical workflow for screening ion exchange chromatography, hydrophobic interaction chromatography, and mixed-mode cation exchange chromatography resins
• Explore how selectivity mapping can reveal promising operating windows
• See how screening results can support scale-up to column confirmation runs

Presenter: Michelle Nolasco (Systems Design Engineer, Thermo Fisher Scientific)

 Michelle Nolasco leads innovation initiatives and collaborations for bioproduction at Thermo Fisher Scientific. Michelle specializes in downstream processes and has experience in automation and advanced analytics.