Proteoform Studio software, top down made simple

Top-down mass spectrometry enables a proteoform-first approach by keeping the protein molecule intact, combining intact mass information with intact-ion fragmentation to support confident characterization of sequences, modifications, variants, and proteoforms. In this webinar, you will see how Thermo Scientific Proteoform Studio brings acquisition, analysis, visualization, and reporting together in a streamlined workflow for intact mass and top-down applications.

By attending this webinar, you will learn how to:

• Understand how top-down MS supports proteoform-first characterization: See how intact mass and intact-ion fragmentation can be used to characterize proteoforms, modifications, variants, and sequence coverage.
• See how Proteoform Studio simplifies acquisition, analysis, and reporting: Learn how integrated instrument control, interactive deconvolution, targeted top-down method creation, database management, result review, and automated reports can reduce workflow complexity.
• Learn how Direct Mass Technology™ and automated workflows can improve data quality and productivity: Explore how Direct Mass Technology™, automated charge assignment, data aggregation, and proteoform tracks can help improve sequence coverage, simplify comparison, and support deeper characterization.

Topics covered:

• Why top-down mass spectrometry matters
• Proteoform Studio for intact protein characterization
• Interactive deconvolution and walk-up analysis
• Mixed and sliding-window deconvolution
• Targeted top-down method creation
• Direct Mass Technology™ workflows
• Proteoform tracks and data aggregation
• Automated reporting

You will leave with a practical understanding of how Proteoform Studio can help streamline intact mass and top-down workflows for applications such as biotherapeutic characterization, antibody analysis, covalent binder localization, native MS, and deep proteoform sequencing.

This webinar is designed for scientists working in:

• Intact protein analysis
• Top-down proteomics
• Native MS
• Biotherapeutic characterization
• Proteoform analysis
• Protein complex or antibody characterization
• Mass spectrometry core facilities supporting intact protein workflows

If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.

Presenter: Jacob McCabe (Product Manager, Proteinaceous- Thermo Fisher Scientific)

Jacob McCabe, Ph.D., is a life-science innovator specializing in mass spectrometry, high-throughput automation, and software engineering who currently serves as a Product Manager at Thermo Fisher Scientific following the acquisition of Proteinaceous in March 2026. With a focus on translating complex research into scalable, user-centric digital solutions, he leads cross-functional teams to bridge laboratory instrumentation with automated workflows