Applications of Multi-Angle Light Scattering for Biotherapeutic Characterization

DAWN MALS for Proteins and Gene Therapy

As biotherapeutics become increasingly complex, comprehensive characterization is essential for understanding critical quality attributes and ensuring product quality. Multi-Angle Light Scattering (MALS) is a powerful analytical technique that provides direct, absolute measurements of multiple molecular attributes in a single experiment, including molar mass, size, conformation, aggregation, and conjugation.

Why you should attend

This webinar introduces the fundamentals of MALS and highlights its application to the characterization of biotherapeutics such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), protein conjugates, and adeno-associated viruses (AAVs).

Attendees will learn how coupling MALS with separation techniques such as SEC enables comprehensive molecular characterization without reliance on calibration standards or molecular assumptions. Through real-world examples, the webinar will demonstrate how MALS helps scientists gain deeper insight into molecular structure, composition, and heterogeneity throughout biotherapeutic development.

• Understand the principles of Multi-Angle Light Scattering (MALS)
• Learn how MALS provides comprehensive characterization of biotherapeutics in a single analysis
• Explore applications for determining molar mass, size, conformation, aggregation, and conjugation
• Discover how MALS supports the development and characterization of mAbs, ADCs, protein conjugates, and AAVs

Who should attend?

• Scientists, Analysts, and Lab Managers in Discovery, Development, Quality Control, or Analytical Services who characterize antibodies, ADCs, and other protein therapeutics.
• CDMO, CRO and other testing organization who are interested in expanding their capabilities

Presenter: Udayabagya (Bud) Halim (Sr. Product Marketing Analyst, Waters Corporation)

Bud Halimis a senior marketing analyst at Waters | Wyatt Technology with a PhD in physical chemistry from UCLA.

He began his career teaching biochemistry and chemistry and contributing to laboratory manuals before transitioning into the scientific instrumentation industry as an applications scientist.

At Waters, he supports researchers in the characterization of peptides, biologics, lipid nanoparticles (LNPs), and viral vectors.