Comprehensive LC-MS Workflows for Antibody Drug Conjugate (ADC) Analysis

This webinar presents a streamlined and sensitive LC-MS workflow for 4 key quantitative pharmacokinetic/pharmacodynamic (PK/PD) assays using trastuzumab deruxtecan (TDx) in rat plasma on a Triple Quad mass spectrometer. Each of these assays provides unique insights into the behavior of the ADC, enabling a comprehensive PK/PD evaluation. Sensitivity and quantitative performance are critical for ADC analysis, enabling accurate and thorough assessments of drug stability, safety, and therapeutic efficacy. The session will highlight assay sensitivity, method robustness, and applicability to bioanalysis.

This session will provide valuable insights into:

• Optimal workflows for ADC quantitation.
• Low levels of LLOQs for payload and peptide assays on the SCIEX 7500+ system.
• Sensitivity and reproducibility in ADC quantitative assays.

Who should attend?

• Scientists and researchers in pharma/biopharma and bioanalytical labs focused on antibody-drug conjugates and PK/PD research.

Presenter: Ebru Selen

Ebru earned her Ph.D. at the University of Wisconsin–Madison and completed postdoctoral training at Johns Hopkins School of Medicine, developing mass spectrometry and NMR methods to study liver metabolism. At SCIEX, she partners with pharma leaders to apply next-generation MS technologies and create innovative workflows that drive sensitivity, selectivity, and robustness in drug development.