The path to perfect peaks: Sample preparation and chromatography for complex matrices

Boost your method development capabilities

Creating a reliable and successful method can be challenging at times, especially if you’re dealing with complex matrices. Finding the right balance can take time. Samples need to be properly prepared and figuring out the right parameters for speed and sensitivity involves trial-and-error, which can be time-consuming.

We want to help make method development a whole lot easier for you. In our Build an LC-MS/MS method with me webinar series, we will guide you through the steps to create a successful method. These 45-minute sessions are led by an application chemist who will focus on building a method that can be used for detecting illicit drugs in seafood using real data collected in our lab.

Part 2: The path to perfect peaks: Sample preparation and chromatography for complex matrices

In this session you will:

• Master LC gradient building and how to obtain optimal peak symmetry using scan methods paired with LC methods
• Explore sample preparation of drugs of abuse in food matrices and understand suppression versus extraction recovery analytes
• Learn how to handle different matrices and matrix effects
• Refine an LC-MS/MS method in real samples for sensitivity, accuracy and precision

Presenter: Diana Tran (Applications Manager, SCIEX)