From Liquid to Ions…. Eliminate your Fears switching from Electrospray ionization (ESI) to Atmospheric Pressure chemical Ionization (APCI)

• Wait what?! Who knew!? There are so many things that a mass spec can do.

• I've used it for years, yes this may be true.

• I've processed some samples, more than a few.

• But between me and you, I had no idea all the things it could do!

• From sample prep to separation, you just won't believe…

• All of the tips and tricks we have up our sleeve.

• So, take a few minutes, about 15 should do.

• And learn all the things your mass spec can do.

Electrospray ionization (ESI) is the most common ionization technique used in LC-MS, however not all samples are best analyzed by ESI. Atmospheric Pressure Chemical Ionization (APCI) is a complementary technique that can work well with small molecules that are more non-polar or neutral. Considerations for solvent and mobile phase additives to optimize APCI performance will be discussed.

Presenter: Emily Parry, PhD (LC/MS Applications Scientist, Agilent Technologies, Inc.)

Emily has been with Agilent for four years. Prior to joining Agilent, Emily developed methods for environmental contaminants in a variety of human and environmental matrices using both targeted and untargeted mass spectrometry techniques. She worked as a researcher at the Environmental Protection Agency (EPA) and Public Health Institute. She received her Ph.D. degree in Environmental Chemistry from the University of California, Davis.