Rapid Oligonucleotides QC with Automated High Resolution ESI-LCMS and BioPharma Compass

Automated High-Throughput Oligo QC: From Automated Sample Preparation to MALDI Spectra Assessment Synthetic oligonucleotides find a variety of applications in molecular biology. Primers for instance are used for DNA sequencing and amplification. Mass spectrometry is a well-established technology for quality…

Application Note # LCMS-78 Automated Analysis of Protein Sequence Variants by LC-MS Under the Control of BioPharma Compass Abstract Here we describe an automated UPLC-MS based method for the analysis and quality confirmation of the intact mass for protein sequence…

Routine analysis of drug to antibody ratio and drug distribution with maXis II Antibody drug conjugates (ADC) are small molecule conjugated mAbs. These are rapidly emerging complex biological molecules in the biopharma space. Abstract Characterization of ADC’s includes intact mass…

Fully automated glycoform profiling and sequence validation of the NIST reference antibody Abstract Two key elements assessed during the analysis of mAb biotherapeutics are the glycosylation profile and the primary sequence. Using the NIST antibody as a model, three complementary…