The combination of MALDI-2 and timsTOF fleX brings targeted drug imaging to the next level

TIMS enabled quantification of small molecules in MALDI Imaging timsTOF fleX was used to demonstrate quantitative mass spectrometry imaging on several drug compounds. Abstract timsTOF fleX was able to separate near-isobaric ions by their ion mobilities, significantly improving targeted compound…

TP-209 Rapid pharmacokinetic analysis of small drugs by mass spectrometry imaging combined with product ion analysis Ariful 1 Islam , 1Department 3 Ogata , M. Nazim of Cellular & Molecular Anatomy, and International Mass Imaging Center, Hamamatsu University School of…

timsTOF MALDI Guided SpatialOMx Innovation with Integrity TIMS-MALDI MS MALDI Guided SpatialOMx The tumor microenvironment is a highly variable ecosystem, giving it an intrinsic temporal character. De-coding the cellular communication within the tumor microenvironment via label-free MALDI Imaging and x-omics…

Tracking free-toxin distribution in xenografts after in-vivo ADC dosing by MALDI Imaging MALDI-MRMS imaging of free released toxin in xenografts after ADC in-vivo dosing. Abstract Antibody-drug conjugates (ADC), a fast-growing class of anticancer drugs, typically comprise a cytotoxic payload that…