MALDI Guided SpatialOMx uncovers proteomic profiles in tumor subpopulations of breast cancer

timsTOF MALDI Guided SpatialOMx Innovation with Integrity TIMS-MALDI MS MALDI Guided SpatialOMx The tumor microenvironment is a highly variable ecosystem, giving it an intrinsic temporal character. De-coding the cellular communication within the tumor microenvironment via label-free MALDI Imaging and x-omics…

Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…

ASMS 2023 Tumor heterogeneity of glioblastoma analyzed via SpatialOMx and HiPLEX-IHC MALDI Imaging Corinna Henkel1, Signe Frost Frederiksen1, Matthias Szesny1, Jörg Bartsch2, Katherine Stumpo3, Melanie Föll4, Oliver Schilling4 1Bruker Daltonics GmbH & Co.KG, 28359 Bremen, Germany 2Department of Neurosurgery/Lab, Faculty…

Novel MALDI Imaging solution empowered by a timsTOF fleX and dedicated bioinformatics pipeline for identification of lipids from tissue MALDI Imaging spectra can be used to investigate how compounds are localized across tissue samples. In this application note, we present…