FRACTION COLLECTION FOR ISOLATING IMPURITIES IN FORCED DEGRADATION STUDIES

FRACTION COLLECTION FOR ISOLATING IMPURITIES IN FORCED DEGRADATION STUDIES Paula Hong and Patricia R. McConville Waters Corporation, Milford, MA 01757 RESULTS AND DISCUSSION INTRODUCTION N- Oxide - 2.616 - QDa Positive Scan Epoxide - 3.828 - QDa Positive Scan RELATIVE…

FRACTION COLLECTION FOR ISOLATING IMPURITIES IN FORCED DEGRADATION STUDIES Paula Hong and Patricia R. McConville Waters Corporation, Milford, MA 01757 RESULTS AND DISCUSSION INTRODUCTION N- Oxide - 2.616 - QDa Positive Scan Epoxide - 3.828 - QDa Positive Scan RELATIVE…

THE USE OF A TRIPLE DETECTION SYSTEM (UV, ELSD, MS) FOR PHARMACEUTICAL DEGRADATION STUDIES Paula Hong, Aaron Phoebe, and Patricia R. McConville Waters Corporation, 34 Maple Street, Milford, MA, USA, 01757 METHODS 0.60 3.50 0.0 0.0 6 6.50 5.0 95.0…

STRATEGIES TO EVALUATE AND MONITOR FORCED DEGRADATION STUDIES USING A DUAL DETECTION (UV-MS) SYSTEM Paula Hong, and Patricia R. McConville Waters Corporation, Milford, MA 01757 INTRODUCTION Forced degradation studies are typically performed to understand the degradation pathway of pharmaceuticals. Given…