Analysis of an Antibody-Drug Conjugate on a Novel Benchtop MALDI-TOF/TOF Platform

Routine analysis of drug to antibody ratio and drug distribution with maXis II Antibody drug conjugates (ADC) are small molecule conjugated mAbs. These are rapidly emerging complex biological molecules in the biopharma space. Abstract Characterization of ADC’s includes intact mass…

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…

Glycosylated and Deglycosylated Subunit Analysis of Antibody Drug Conjugates Trastuzumab Emtansine Analysis using Benchtop X500B QTOF Mass Spectrometer Wen Jin, Suya Liu, Doug Simmons, Ian Moore and Sibylle Heidelberger 71 Four Valley Dr. Concord, ON L4K 4V8, Canada Introduction Experimental…

Biopharma Workflow Solutions ACCELERATE ADC DAR CHARACTERIZATION WORKFLOW SOLUTIONS FOR ADC DAR ANALYSIS OVERVIEW The goal of drug discovery is to find drugs that have a wide differential between the effective dose and the dose where serious side effects are…