Streamlined Analysis of Synthetic Peptides with Non-Standard Amino Acid Chemistry

Poster Reprint ASMS 2025 Poster number WP 603 Structural Characterization of Multiple GLP-1 Receptor Agonists using Electron Capture Dissociation Rachel Franklin1; Julie Horner-Buxton2; Joseph C. Meeuwsen1; Thomas E. Walker3; Mike Hare1 1Agilent Technologies, Inc., Corvallis, OR; 2Agilent Technologies, Santa Clara,…

Transformative Workflows for Protein Characterization: ECD and Multidimensional Separations Expert Insights Sponsored by Expert Insights Contents Introduction 3 The Role of Electron Capture Dissociation in Biomolecular Analysis Adapted from Cooper, et al. 4 Offline Coupling of Hydrophobic Interaction Chromatography– Capillary…

Application Note Biopharma Comprehensive Characterization of Multiple GLP-1 Analogs Using an Agilent 6545XT AdvanceBio LC/Q-TOF with electron capture dissociation and ExDViewer software Authors Rachel Franklin, Mike Hare, Thomas Walker, and Joseph Meeuwsen Agilent Technologies, Inc. Abstract GLP-1 analogs are synthetic…

Application Note Biopharma Identification of Amino Acid Isomers Using Electron Capture Dissociation in the Agilent 6545XT AdvanceBio LC/Q-TOF System Authors Rachel Franklin and Joseph Meeuwsen Agilent Technologies, Inc. Abstract Accurately determining the amino acid sequence is crucial for understanding a…