Analysis of Impurities in Oligonucleotide Therapeutics

ERAS-1000-0584 LC-MS Reversed-phase Shim-packTM Series Shim-pack ScepterTM Claris C18-120 584 Analysis of Synthetic DNA Keywords: Oligonucleotides, pharmaceuticals 1. Synthetic DNA [HPLC conditions] (NexeraTM XS inert) Column : Shim-pack Scepter Claris C18-120, 100 mm x 2.1 mm I.D., 1.9 µm*1 Flow…

Efficient Method Development of Small Interfering RNA by Reversed-Phase Ion-Pair Chromatography Daiki 1 Fujimura , Yusuke 1 Osaka 1Shimadzu , Corporation Chromatograms measured under the concentration of HFIP (100 and 200 mmol/L) are shown in Fig.5. The result shows that…

C190-E221E Shim-pack Scepter LC Columns Hybrid Technology for Versatility and Superior Performance Broad pH tolerance (pH 1 to 12*) for use with a wide range of method conditions Eight stationary phases and Three column hardware types for extensive sample coverage…

Nexera™ XS inert High Performance Liquid Chromatograph LCMS-2050 Liquid Chromatograph Mass Spectrometer Application News Simple Analysis of Impurities in Oligonucleotide Therapeutics Using a Single Quadrupole Mass Spectrometer Takanari Hattori, Noriko Kato, and Junna Nakazono User Benefits  Oligonucleotides and related…