Protein Folding

W H I T E PA P E R WP5004: The diffusion interaction parameter (kD) as an indicator of colloidal and thermal stability Sophia Kenrick, Ph.D. and Daniel Some, Ph.D., Wyatt Technology Corp. Summary Stability is a key quality attribute…

Monitoring RNA Folding Intermediates using the DynaPro Plate Reader Plus Nathan J. Baird, Tobin R. Sosnick, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago IL 60637 Sigrid C. Kuebler, Wyatt Technology Corporation, 6300 Hollister Ave, Santa Barbara, CA…

Light Scattering for the Masses™ DynaPro Characterization of α-synuclein Oligomerization he aggregation of the presynaptic protein αsynuclein is believed to play a critical role in Parkinson’s disease. It is suspected that pre-fibrillar oligomers, rather than fibrils themselves, may be the…

W H I T E PA P E R WP5010: Screening Developability and Pre-Formulation of Biotherapeutics with High-Throughput Dynamic Light Scattering (HT–DLS) Daniel Some, Ph.D., Wyatt Technology Corp. Introduction Assessing a drug candidate’s suitability early in the discovery and development…