Determination of mRNA Encapsulation Efficiency with the Agilent 1290 Infinity II Bio LC System

Application Note Biopharmaceuticals LC/MS Analysis of Lipid Composition in an mRNA LNP Formulation: A Stability Study Authors Li Zhang and Yi Yan Yang Bioprocessing Technology Institute Suresh Babu C.V. and Ravindra Gudhial Agilent Technologies, Inc. Abstract Lipid-based nanocarriers, known as…

Application Note Biopharmaceuticals Analysis of Lipid Nanoparticle Components Using an Agilent 6545XT AdvanceBio LC/Q-TOF Authors Li Zhang and Yi Yan Yang Bioprocessing Technology Institute, Agency for Science, Technology, and Research (A*STAR) Republic of Singapore Suresh Babu C.V. and Ravindra Gudhial…

APPLICATION NOTE Skip the mess with dye-free LNP payload quant on Stunner Introduction Everyone who’s worked with lipid nanoparticles (LNPs) has used a fluorescent dye-based assay to quantify the RNA content and encapsulation efficiency (EE%) of their formulations and production…

APPLICATION NOTE Flexible nanoparticle development: process optimization & scale-up of a wide range of synthetic nanomedicines with Sunshine Introduction In contrast, by using microfluidic technology to combine reactants in a precise mixing geometry using stable, highly controlled, laminar flows, the…