IMPACT OF HPLC INSTRUMENTATION ON NON- SPECIFIC ADSORPTION OF PEPTIDES

MODERNIZING BIOTHERAPEUTIC COMPENDIAL METHODS WITH A NEXT-GENERATION HPLC SYSTEM Pawel Bigos, Duanduan Han, Xiangsha Du, Robert Birdsall, Andrea Hoehnel, Karen Nyholm Waters Corporation INTRODUCTION RESULTS AND DISCUSSION As the field of analytics continues to evolve, methods guided by regulatory general…

METHOD TRANSFER AND ROUTINE ANALYSIS OF PROTEIN AND PEPTIDE-BASED DRUG PRODUCTS USING A BIOCOMPATIBLE UHPLC SYSTEM Brooke M. Koshel, Robert Birdsall, Corey Reed, Stephan Koza, Zhimin Li, Paula Hong, Joe Fredette, and Scott Berger Waters Corporation INTRODUCTION Many of the…

Application Note Leveraging the Alliance™ iS Bio HPLC System as a Modern HPLC for Peptide Drug Substances Analysis in QC Environments Duanduan Han, Robert E. Birdsall, Karen Nyholm Waters Corporation Abstract The Alliance iS Bio HPLC System with MaxPeak™ High…

Evaluation of Pump Performance for Long Shallow Gradient Peptide Mapping Analysis Andrew Steere, Norris Wong, Paula Hong Waters Corporation, Milford, MA, 01757 RESULTS AND DISCUSSION INTRODUCTION Peptide mapping is a critical tool in biopharmaceutical analysis for characterization and impurity testing.…