Metacomplex Formation & Binding Affinity of Multivalent Binding Partners

Light Scattering for the Masses ® Binding Affinity and Stoichiometry of a Multivalent Protein-aptamer Association Summary ecause proteins are often multimeric in their native state, the biomarker targets of many pharmaceuticals present multiple binding sites. In the case of monoclonal…

Light Scattering for the Masses ® Measuring the Interaction Between Thrombin-α and an Anti-Thrombin Antibody Summary Antibody-antigen binding, hormone-receptor interactions, and many other common biomolecular interactions occur at stoichiometries other than 1:1. The Wyatt Calypso system utilizes composition-gradient multi-angle light…

A P P L I C AT I O N N O T E AN3006: Fusion protein complexes analyzed by CG-MALS—non-equivalent, multivalent interactions Sophia Kenrick, Ph.D., Wyatt Technology Corporation Summary Quantifying binding affinity between species with multiple binding sites can…

AN3002: Understanding antibody and viral glycoprotein interactions using CG-MALS Kathryn M. Hastie, Ph.D., and Erica Ollmann Saphire, Ph.D., The Scripps Research Institute Summary Viral glycoproteins are often the only antigen found on the viral surface and, as such, are key…