ADC drug-antibody ratio (DAR) determined by SEC-MALS

WP1621: Multi-Attribute Quantitation of Antibody-Drug Conjugates by LC-MALS Hongjiang (Leo) Liu, Ph.D., and Sophia Kenrick, Ph.D., Wyatt Technology, LLC Summary Liquid chromatography combined with multi-angle light scattering (LC-MALS) is a powerful tool for analyzing antibody-drug conjugates (ADCs), providing a robust…

I TEE PPAAPPEERR WWHHI T WP1615: SEC-MALS for absolute biophysical characterization Daniel Some, Ph.D., Waters | Wyatt Technology Summary Accurate characterization of biomacromolecules is essential for successful programs of research and development in the life sciences and biopharmaceuticals. The basic…

Aggregation of Antibody-Drug Conjugates: The Light Scattering Toolbox for Screening and Characterization SEC-MALS  FFF-MALS  CG-MALS  DLS  MP-PALS Molar Mass  Size  Charge  Conjugation  Interactions Chris Broomell and Daniel Some, Wyatt Technology Corporation, 6300…

Multi-Angle Light Scattering goes micro Dr. Dierk Roessner International Symposium on GPC/SEC and Related Techniques Frankfurt 2014 © 2014 Wyatt Technology Europe GmbH - All Rights reserved Page 1 Overview Why use Multi Angle Light Scattering ? Challenges coupling UV…