MULTI-STEP WORKFLOW FOR VISUALIZATION OF DRUG/METABOLITES AND METABOLISM WITH DESI TQ AND DESI Q-TOF MASS SPECTROMETERS

NOVEL TARGETED DESI MRM TQ SYSTEM PROVIDING INCREASED SENSITIVITY AND ACQUISITION SPEED FOR MASS SPECTROMETRY IMAGING Emmanuelle Claude1, Steven Pringle1, Joanne Ballantyne1 1 Waters Corporation, Wilmslow, UK INTRODUCTION Gefitinib was detected with a S/N ~ 2,500 and was at least…

VISUALIZATION AND QUANTIFICATION OF DRUG/METABOLITES BY SENSITIVE AND FAST TARGETED DESI IMAGING ON TQ SYSTEM Emmanuelle Claude1, Ross Chawner1, Nathalie Delallée2, Stephanie Molez2, Gregory Nicolas2, Joanne Ballantyne1 1 Waters Corporation, Wilmslow, UK; 2Bioprojet, Saint Gregoire, France INTRODUCTION Mass spectrometry (MS)…

IMPROVING SPATIAL DISTRIBUTION, SENSITIVITY AND SELECTIVITY IN MSI, USING A NOVEL DESI QQQ AND A HR-MULTI REFLECTING TOF SYSTEMS Emmanuelle Claude1; Farid Jahouh2; Martin Palmer1; Inneke Wynant2; Filip Cuyckens2, Marjolein Van Heerden2; Jan Claereboudt3; Rob J Vreeken2,4, Lance Nicolaysen5 1…

Targeted MS Imaging Solution with DESI XS and XEVO TQ Absolute MS Imaging has evolved. Harness Absolute confidence with Absolute sensitivity. TM TQ ABSOLUTE [ TAGETED MS IMAGING ] Targeted MS Imaging for sensitive, selective and fast molecular visualization Combine…